Both E12 and E47 Allow Commitment to the B Cell Lineage

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

The helix-loop-helix gene E2A is required for B cell formation

1994 • 679 citations

Failure of B-cell differentiation in mice lacking the transcription factor EBF

1995 • 667 citations

Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif

1990 • 478 citations

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

1992 • 450 citations

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

1994 • 426 citations

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

1993 • 345 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

VDJ recombination

1992 • 307 citations

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.

1991 • 289 citations

Constitutive expression of the Id1 gene impairs mouse B cell development

1994 • 266 citations

Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression.

1993 • 256 citations

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.

1990 • 244 citations

Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line.

1991 • 240 citations

A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors.

1996 • 236 citations

Interleukin 7 production and function in stromal cell-dependent B cell development.

1989 • 221 citations

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.

1994 • 189 citations

B-Cell-Specific DNA Binding by an E47 Homodimer

1995 • 187 citations

A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.

1993 • 173 citations

B-Cell- and Myocyte-Specific E2-Box-Binding Factors Contain E12/E47-Like Subunits

1991 • 164 citations

A New Transcriptional-Activation Motif Restricted to a Class of Helix-Loop-Helix Proteins Is Functionally Conserved in Both Yeast and Mammalian Cells

1993 • 158 citations

Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice

1995 • 155 citations

E2A and E2-2 are Subunits of B-Cell-Specific E2-Box DNA-Binding Proteins

1993 • 153 citations

Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies.

1992 • 146 citations

The E2A gene product contains two separable and functionally distinct transcription activation domains.

1993 • 138 citations

Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors.

1991 • 123 citations

The AD1 Transactivation Domain of E2A Contains a Highly Conserved Helix Which Is Required for Its Activity in both Saccharomyces cerevisiae and Mammalian Cells

1996 • 108 citations

An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures

1994 • 102 citations

A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells.

1993 • 72 citations

A Heterodimer of HEB and an E12-Related Protein Interacts with the CD4 Enhancer and Regulates Its Activity in T-Cell Lines

1993 • 71 citations

Predominance of the prototypic T15 anti-phosphorylcholine junctional sequence in neonatal pre-B cells.

1991 • 67 citations

E2A expression, nuclear localization, and in vivo formation of DNA- and non-DNA-binding species during B-cell development.

1993 • 66 citations

E2A Expression, Nuclear Localization, and In Vivo Formation of DNA- and Non-DNA-Binding Species during B-Cell Development

1993 • 27 citations

In vitro tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors

1996 • 26 citations