ON IMMUNOLOGICAL MEMORY

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Immunity to Intracellular Bacteria

1993 • 1,085 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

1988 • 930 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Fundamental Immunology

1994 • 903 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin

1965 • 710 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Immunology Taught by Viruses

1996 • 656 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

The Virology and Immunobiology of Lymphocytic Choriomeningitis Virus Infection

1980 • 554 citations

Epitopes on protein antigens: Misconceptions and realities

1990 • 532 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

Virus-specific CD8+ T-cell memory determined by clonal burst size

1994 • 525 citations

Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

1987 • 505 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

NEUTRALIZING ANTIVIRAL B CELL RESPONSES

1997 • 467 citations

B–cell memory is short-lived in the absence of antigen

1988 • 430 citations

Lymphocytic Choriomeningitis Virus

2016 • 423 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

Lymphocyte life-span and memory

1994 • 405 citations

Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity.

1994 • 400 citations

Cell-Mediated Immune Response to Human Immunodeficiency Virus (HIV) Type 1 in Seronegative Homosexual Men with Recent Sexual Exposure to HIV-1

1992 • 392 citations

Antigens in Immunity

1966 • 372 citations

Pathogenesis of Infectious Disease

1978 • 371 citations

T cell memory is short-lived in the absence of antigen.

1991 • 367 citations

Antibody-Mediated Clearance of Alphavirus Infection From Neurons

1991 • 356 citations

Lactate Dehydrogenase-Elevating Virus, Equine Arteritis Virus, and Simian Hemorrhagic Fever Virus: A New Group of Positive-Strand RNA Viruses

1992 • 352 citations

Follicular Dendritic Cells as Accessory Cells

1990 • 351 citations

The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory.

1993 • 350 citations

Maintenance of B-cell memory by long-lived cells generated from proliferating precursors

1990 • 323 citations

Cross‐protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity

1984 • 320 citations

The Molecular Biology of Influenza Virus Pathogenicity

1988 • 318 citations

Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses.

1994 • 317 citations

The Maintenance and Regulation of the Humoral Immune Response: Persisting Antigen and the Role of Follicular Antigen‐Binding Dendritic Cells as Accessory Cells

1980 • 313 citations

The Biology of Lymphocytic Choriomeningitis Infection: Virus-induced Immune Disease

1962 • 309 citations

Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus

1986 • 305 citations

Homing of naive, memory and effector lymphocytes

1993 • 295 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

Resistance to Intracellular Infection

1971 • 288 citations

T‐Cell‐Mediated Immunopathology in Viral Infections

1974 • 287 citations

The roles of perforin‐ and Fas‐dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

1995 • 286 citations

The Regulation of Lymphocyte Traffic

1986 • 285 citations

T-cell memory: the connection between function, phenotype and migration pathways

1991 • 271 citations

Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization

1990 • 268 citations

Homing Receptors and the Control of Lymphocyte Migration

1986 • 265 citations

The Biology of animal viruses

1974 • 263 citations

Requirement for Θ-Bearing Cells in Lymphocytic Choriomeningitis Virus-induced Central Nervous System Disease

1972 • 262 citations

Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family

1977 • 260 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

The Biology of Animal Viruses

1975 • 247 citations

The synergy between naive and memory T cells during activation

1991 • 247 citations

Antibody-mediated enhancement of disease in feline infectious peritonitis: Comparisons with dengue hemorrhagic fever

1981 • 239 citations

The Protection: The Unit of Humoral Immunity Selected by Evolution

1990 • 236 citations

T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS

1994 • 235 citations

A Quantitative Dose-Response Study of Lymphoid-Tumor Development in Irradiated C57 Black Mice<xref ref-type="fn" rid="fn1"><sup>2</sup></xref>

1952 • 234 citations

Lymphocyte homing receptors

1986 • 231 citations

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

1995 • 225 citations

Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor

1992 • 221 citations

A case for cytokines as effector molecules in the resolution of virus infection

1993 • 216 citations

Variation of Influenza A, B, and C Viruses

1982 • 207 citations

Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen.

1992 • 204 citations

Pathogenic Properties, and "Vertical" Transmission of the Mouse Leukemia Agent.

1951 • 201 citations

A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice2

1973 • 200 citations

Antigens, Lymphoid Cells and the Immune Response

1971 • 200 citations

Functional analysis of influenza-specific helper T cell clones in vivo. T cells specific for internal viral proteins provide cognate help for B cell responses to hemagglutinin.

1986 • 199 citations

Isoallergic Encephalomyelitis and Radiculitis in Guinea Pigs After One Injection of Brain and Mycobacteria in Water-in-Oil Emulsion

1947 • 199 citations

Mouse-Pox (Infectious Ectromelia of Mice): A Review

1949 • 199 citations

Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.

1995 • 197 citations

Induction of long-lived germinal centers associated with persisting antigen after viral infection.

1996 • 192 citations

The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen.

1994 • 190 citations

Memory B and T Cells

1991 • 183 citations

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

1994 • 175 citations

Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells.

1992 • 174 citations

Antigenic drift in type A influenza virus: Sequence differences in the hemagglutinin of Hong Kong (H3N2) variants selected with monoclonal hybridoma antibodies

1979 • 174 citations

OCCURRENCE OF DELAYED HYPERSENSITIVITY DURING THE DEVELOPMENT OF ARTHUS TYPE HYPERSENSITIVITY

1958 • 174 citations

An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.

1991 • 172 citations

Immunological Memory

1993 • 166 citations

Ueber Immunität durch Vererbung und Säugung

1892 • 159 citations

On the cellular basis of immunological T cell memory

1995 • 159 citations

Immunology and the liver

1991 • 146 citations

Germinal Centers and Antibody Production in Bone Marrow

1992 • 135 citations

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

1993 • 133 citations

RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.

1992 • 132 citations

Expression of defective measles virus genes in brain tissues of patients with subacute sclerosing panencephalitis

1986 • 131 citations

Enhancement of feline immunodeficiency virus infection after immunization with envelope glycoprotein subunit vaccines

1995 • 126 citations

A History of Transplantation Immunology

2011 • 124 citations

Anti‐viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia‐recombinant virus expressing LCMV‐WE nucleoprotein or glycoprotein

1989 • 123 citations

H-2 restriction of virus-specific T-cell-mediated effector functions in vivo. II. Adoptive transfer of delayed-type hypersensitivity to murine lymphocytic choriomeningits virus is restriced by the K and D region of H-2.

1976 • 120 citations

Vaccination for Disease

1991 • 117 citations

The Cellular Basis of Immunologic Memory

1971 • 111 citations

T cell memory. Long-term persistence of virus-specific cytotoxic T cells.

1989 • 109 citations

The immunological principles of vaccination

1990 • 108 citations

The Murine Sarcoma Virus-Induced Tumor: Exception or General Model in Tumor Immunology?

1977 • 108 citations

Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection.

1992 • 107 citations

Analysis of the fine specificity of rat, mouse and human TAP peptide transporters

1995 • 102 citations

The pathogenesis of infectious disease

1988 • 102 citations

Characterization of the murine TH response to influenza virus hemagglutinin: evidence for three major specificities.

1984 • 99 citations

Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells.

1994 • 97 citations

T and B cell Tolerance and Responses to Viral Antigens in Transgenic Mice: Implications for the Pathogenesis of Autoimmune versus Immunopathological Disease

1991 • 97 citations

CD8+ T-cell memory to viruses

1994 • 96 citations

Immunoglobulins in bovine mammary secretions. Quantitative changes in early lactation and absorption by the neonatal calf.

1972 • 95 citations

The pathogenesis of infectious disease

1983 • 94 citations

Anomalous reactions of mouse alloantisera with cultured tumor cells. II. Cytotoxicity is caused by antibodies to leukemia viruses.

1975 • 93 citations

Induction of protective cytotoxic T cells with viral proteins

1994 • 91 citations

Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon

1994 • 89 citations

T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs.

1993 • 88 citations

Effector T‐Cell Induction and T‐Cell Memory versus Peripheral Deletion of T Cells

1993 • 87 citations

Mechanisms of antibody-mediated protection against lymphocytic choriomeningitis virus infection: mother-to-baby transfer of humoral protection

1992 • 85 citations

Capacity of Sensitized Thymus-Derived Lymphocytes to Induce Fatal Lymphocytic Choriomeningitis Is Restricted by the H-2 Gene Complex

1975 • 85 citations

In vivo state of antiviral CTL precursors. Characterization of a cycling cell population containing CTL precursors in immune mice.

1995 • 81 citations

The Recovery of Mice from Influenza Virus Infection: Adoptive Transfer of Immunity with Immune T Lymphocytes

1978 • 81 citations

Lymphocytic choriomeningitis virus killer T cells are lethal only in weakly disseminated murine infections.

1982 • 77 citations

Persistent and slow virus infections

1971 • 76 citations

The immune response of the mouse to lymphocytic choriomeningitis virus V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection

1987 • 72 citations

Anomalous Reactions of Mouse Alloantisera with Cultured Tumor Cells

1975 • 72 citations

Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomeningitis virus‐infected mice with anti‐interferon‐γ monoclonal antibody blocks generation of virus‐specific cytotoxic T lymphocytes and virus elimination

1989 • 71 citations

Expansion, Selection and Maintenance of Memory B-Cell Clones

1990 • 66 citations

Cellular Immunity (Part 1 of 2)

1967 • 62 citations

Perforin expression in human peripheral blood mononuclear cells. Definition of an IL-2-independent pathway of perforin induction in CD8+ T cells.

1992 • 62 citations

Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen.

1992 • 58 citations

Antiviral antibodies attenuate T-cell-mediated immunopathology following acute lymphocytic choriomeningitis virus infection

1991 • 58 citations

Analysis of the kinetics of antiviral memory T help in vivo: characterization of short‐lived cross‐reactive T help

1990 • 55 citations

Virus-induced delayed-type hypersensitivity reaction is sequentially mediated by CD8+ and CD4+ T lymphocytes.

1989 • 55 citations

Regulation of IgG antibody titers by the amount persisting of immune‐complexed antigen

1994 • 55 citations

The effects of idiotype on the ability of IgG₁ antiphosphorylcholine antibodies to protect mice from fatal infection with Streptococcus pneumoniae

1984 • 53 citations

Primary antibody responses to a well-defined and unique hapten are not enhanced by preimmunization with carrier: analysis in a viral model.

1986 • 50 citations

Extensive diversity in the recognition of influenza virus hemagglutinin by murine T helper clones.

1986 • 50 citations

The immune system

1989 • 48 citations

Abrogation of tolerance to a chronic viral infection.

1991 • 47 citations

Immunological memory against viruses.

1992 • 46 citations

Spontaneous Tumors of Aging Wild House Mice, Incidence, Pathology, and C-Type Virus Expression2

1973 • 46 citations

ON THE ROLE OF VIRUSES IN THE EVOLUTION OF IMMUNE RESPONSES

1985 • 46 citations

Introduction

2015 • 46 citations

Split tolerance in spleen chimeras.

1995 • 45 citations

Antigenic determinants of vesicular stomatitis virus: analysis with antigenic variants.

1983 • 43 citations

Skin test to assess virus-specific cytotoxic T-cell activity.

1992 • 43 citations

Enhancement of disease by neutralizing antiviral antibodies in the absence of primed antiviral cytotoxic T cells

1993 • 42 citations

Characterization of T-helper epitopes of the glycoprotein of vesicular stomatitis virus

1994 • 39 citations

Cross Recognition and Cross Reactivity

1967 • 39 citations

Antiviral T-Cell Memory?

1990 • 30 citations

In vitro primary induction of cytotoxic T cells against virus-infected syngeneic cells

1977 • 27 citations

In vivo versus in vitro assays for assessment of T- and B- cell function

1994 • 27 citations

Vaccination with a synthetic peptide modulates lymphocytic choriomeningitis virus-mediated immunopathology

1992 • 24 citations

Searching for MHC‐restricted anti‐viral antibodies: antibodies recognizing the nucleoprotein of influenza virus dominate the serological response of C57BL/6 mice to syngeneic influenza‐infected cells

1987 • 24 citations

Activation of Spontaneous Murine Leukemia Virus-Related Antigen by Lymphocytic Choriomeningitis Virus

1971 • 22 citations

Comparison of the Sensitivity of in Vivo and in Vitro Assays for Detection of Antiviral Cytotoxic T Cell Activity

1993 • 20 citations

Primary in vitro sensitization of virus specific cytotoxic T lymphocytes.

1978 • 15 citations

Real and imagined dangers

1991 • 14 citations

THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION

1968 • 13 citations

The Joint Evolution of Antigens and Antibodies

2015 • 7 citations

Immunology and the liver

1991 • 5 citations