A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3′ enhancer.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

T Cell-Dependent B Cell Activation

1993 • 727 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

1989 • 698 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins.

1991 • 543 citations

Humoral immune responses in CD40 ligand-deficient mice.

1994 • 541 citations

Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain

1988 • 455 citations

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

1994 • 431 citations

The role of CD40 in the regulation of humoral and cell-mediated immunity

1994 • 376 citations

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.

1993 • 372 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations.

1991 • 309 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

T cell independent antigens

1995 • 282 citations

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1994 • 267 citations

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation.

1993 • 261 citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2.

1994 • 238 citations

Induction of Apoptosis by c-Fos Protein

1996 • 224 citations

A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

1990 • 220 citations

The B-cell antigen receptor complex: structure and signal transduction

1994 • 204 citations

Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins.

1992 • 198 citations

Induction of the transcription factors NF-кB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor

1995 • 192 citations

A direct physical association between ETS and AP-1 transcription factors in normal human T cells

1995 • 184 citations

Transcriptional regulation by Fos and Jun in vitro: interaction among multiple activator and regulatory domains.

1991 • 175 citations

Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.

1996 • 175 citations

Selective Activation of c-Jun Kinase Mitogen-activated Protein Kinase by CD40 on Human B Cells

1995 • 172 citations

Transcriptional Activation of the fra-1 Gene by AP-1 Is Mediated by Regulatory Sequences in the First Intron

1995 • 162 citations

B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes.

1995 • 149 citations

Two functionally different regions in Fos are required for the sequence-specific DNA interaction of the Fos/Jun protein complex

1989 • 147 citations

T cell-dependent activation of B cell proliferation and differentiation by immobilized monoclonal antibodies to CD3.

1988 • 144 citations

The B cell-specific transcription factor BSAP regulates B cell proliferation.

1994 • 140 citations

The mouse IgH 3′‐enhancer

1991 • 139 citations

Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny.

1991 • 139 citations

An enhancer at the 3′ end of the mouse immunoglobulin heavy chain locus

1991 • 116 citations

Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti‐mouse CD40 antibodies

1994 • 112 citations

An enhancer element in the short unique region of human cytomegalovirus regulates the production of a group of abundant immediate early transcripts

1988 • 110 citations

Stimulation of B-cell proliferation by membrane-associated molecules from activated T cells.

1988 • 98 citations

Pax5 (BSAP) regulates the murine immunoglobulin 3' alpha enhancer by suppressing binding of NF-alpha P, a protein that controls heavy chain transcription.

1995 • 97 citations

T cell-dependent induction of NF-kappa B in B cells.

1993 • 93 citations

c-fos expression interferes with thymus development in transgenic mice

1988 • 84 citations

Transformation by Fos proteins requires a C-terminal transactivation domain.

1993 • 82 citations

Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.

1995 • 79 citations

IgM receptor-mediated transactivation of the IgH 3′ enhancer couples a novel Elf-1-AP-1 protein complex to the developmental control of enhancer function.

1995 • 69 citations

Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3′ enhancer

1992 • 61 citations

Activation of human B lymphocytes: frequency of antigen‐specific B cells triggered by alloreactive or by antigen‐specific T cell clones

1983 • 56 citations

Lipopolysaccharide‐dependent transactivation of the temporally regulated immunoglobulin heavy chain 3′ enhancer

1994 • 55 citations

Cellular selection leads to age-dependent and reversible down-regulation of transgenic immunoglobulin light chain genes

1989 • 33 citations

Fos, Jun and CREB basic-domain peptides have intrinsic DNA-binding activity enhanced by a novel stabilizing factor.

1990 • 30 citations

Transformation by Fos Proteins Requires a C-Terminal Transactivation Domain

1993 • 18 citations

Elevated expression levels of an Ig transgene in mice links the IgH 3′ enhancer to the regulation of IgH expression

1996 • 14 citations

Direct human T helper cell-induced B cell activation is not mediated by inositol lipid hydrolysis.

1988 • 14 citations

B-cell diseases

1993 • 1 citations