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Learned helplessness in the rat.

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Knockouts model the 100 best-selling drugs—will they model the next 100?

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Cytokine Production and Serum Proteins in Depression

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Reduction in the Density and Expression, But Not G-Protein Coupling, of Serotonin Receptors (5-HT_1A) in 5-HT Transporter Knock-Out Mice: Gender and Brain Region Differences

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Withdrawal from chronic amphetamine induces Depressive-Like behavioral effects in rodents

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Ethological strategies for defence in animals and humans: Their role in some psychiatric disorders

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Early Changes in Prefrontal Activity Characterize Clinical Responders to Antidepressants

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The α_2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety

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Altered fear circuits in 5-HT1A receptor KO mice

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Individual response profiles of male Wistar rats in animal models for anxiety and depression

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Reduced anxiety and improved stress coping ability in mice lacking NPY‐Y2 receptors

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Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression.

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Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test

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Withdrawal following repeated exposure to d -amphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement

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Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression.

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Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice.

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Key Role of 5-HT_1BReceptors in the Regulation of Paradoxical Sleep as Evidenced in 5-HT_1BKnock-Out Mice

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Elucidation of the neurobiology of depression: insights from a novel genetic animal model

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α2-Adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression

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Olfactory bulbectomy as a model for agitated hyposerotonergic depression

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Increased Depression-Like Behaviors in Corticotropin-Releasing Factor Receptor-2-Deficient Mice: Sexually Dichotomous Responses

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Long‐Term Antidepressant Treatment Reduces Behavioural Deficits in Transgenic Mice with Impaired Glucocorticoid Receptor Function

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Learned immobility explains the behavior of rats in the forced swimming test

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Involvement of 5-HT_1A Receptors in Homeostatic and Stress-Induced Adaptive Regulations of Paradoxical Sleep: Studies in 5-HT_1A Knock-Out Mice

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Sex-dependent effects of inescapable shock administration on shuttlebox-escape performance and elevated plus-maze behavior

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Altered dendritic spine density in animal models of depression and in response to antidepressant treatment

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Comparison of the phenotype of NK1R−/− mice with pharmacological blockade of the substance P (NK 1 ) receptor in assays for antidepressant and anxiolytic drugs

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Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice

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Forced swimming test in rats: effect of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate

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Functional evidence for subsensitivity of noradrenergic α2 receptors after chronic desipramine treatment

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Reward Value of Cigarette Smoking for Comparably Heavy Smoking Schizophrenic, Depressed, and Nonpatient Smokers

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Diminished Anxiety- and Depression-Related Behaviors in Mice with Selective Deletion of theTac1Gene

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Serotonin ClearanceIn VivoIs Altered to a Greater Extent by Antidepressant-Induced Downregulation of the Serotonin Transporter than by Acute Blockade of this Transporter

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Failure to Change Exploration or Saccharin Preference In Rats Exposed to Chronic Mild Stress

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Elevated Tyrosine Hydroxylase in the Locus Coeruleus of Suicide Victims

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Monoamine metabolism changes following the mouse forced swimming test but not the tail suspension test

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Severe Impairment of NMDA Receptor Function in Mice Carrying Targeted Point Mutations in the Glycine Binding Site Results in Drug-Resistant Nonhabituating Hyperactivity

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G Protein‐Coupled Cyclic AMP Signaling in Postmortem Brain of Subjects with Mood Disorders

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Limitations on the use of the C57BL/6 mouse in the tail suspension test

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Treatment strategies for chronic and refractory obsessive-compulsive disorder.

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Hippocampal atrophy in major depression: a result of depression-induced neurotoxicity?

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5-Hydroxytryptamine (5-HT)_1A Autoreceptor Adaptive Changes in Substance P (Neurokinin 1) Receptor Knock-Out Mice Mimic Antidepressant-Induced Desensitization

2001 • 135 citations

Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects

2003 • 135 citations

Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-α gene: implications for emotional behavior

2000 • 134 citations

Circadian rhythms and depression: effects of exercise in an animal model

1999 • 133 citations

Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice

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Elevated agonist binding to α2-adrenoceptors in the locus coeruleus in major depression

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?-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo

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Use of dopamine-beta-hydroxylase-deficient mice to determine the role of norepinephrine in the mechanism of action of antidepressant drugs.

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Stressor-provoked behavioral changes in six strains of mice.

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Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat

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Repeated variable prenatal stress alters pre‐ and postsynaptic gene expression in the rat frontal pole

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Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180

2000 • 127 citations

Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin

2000 • 127 citations

Murine models of depression

1999 • 126 citations

Effects of maternal stress during pregnancy on forced swimming test behavior of the offspring

1991 • 125 citations

Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels

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Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome

2001 • 123 citations

U.S. experience with valproate in manic depressive illness: a multicenter trial.

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Blockade of nociceptin/orphanin FQ–NOP receptor signalling produces antidepressant‐like effects: pharmacological and genetic evidences from the mouse forced swimming test

2003 • 121 citations

Reduced phosphorylation of cyclic AMP-responsive element binding protein in the postmortem orbitofrontal cortex of patients with major depressive disorder

2003 • 120 citations

HPA axis dysregulation in mice overexpressing corticotropin releasing hormone

2002 • 120 citations

Hyperactivity and Reduced Energy Cost of Physical Activity in Serotonin 5-HT2C Receptor Mutant Mice

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The effects of chronic mild stress on male Sprague–Dawley and Long Evans rats

2002 • 118 citations

Sex differences in emotional and cognitive behaviour in mammals including man: Adaptive and neural bases

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Involvement of 5-HT 1A Receptors in Animal Tests of Anxiety and Depression: Evidence from Genetic Models

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Discovery of antidepressant activity by forced swimming test may depend on pre-exposure of rats to a stressful situation

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The HPA system during the postnatal development of CD1 mice and the effects of maternal deprivation

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The Genes and Brains of Mice and Men

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Intracranial self-stimulation and sucrose intake differ as hedonic measures following chronic mild stress: interstrain and interindividual differences

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Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat

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Models of cognitive impairment: cognitive changes in depression.

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Sex differences in the effects of neonatal handling on the animal's response to stress and the vulnerability for depressive behaviour

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Imaging brain activity in conscious animals using functional MRI

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Additivity of neurochemical changes in learned helplessness and imipramine

1982 • 110 citations

Neonatal administration of the selective serotonin reuptake inhibitor Lu 10-134-C increases forced swimming-induced immobility in adult rats: a putative animal model of depression?

1997 • 110 citations

Plasma neurotransmitters, blood pressure, and heart rate during supine-resting, orthostasis, and moderate exercise conditions in major depressed patients

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Identification of Multiple Genetic Loci Linked to the Propensity for “Behavioral Despair” in Mice

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Searching—waiting strategy: A candidate for an evolutionary model of depression?

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Functional Consequences of 5-HT Transporter Gene Disruption on 5-HT_1AReceptor-Mediated Regulation of Dorsal Raphe and Hippocampal Cell Activity

2001 • 106 citations

Alcohol and genetics: New models

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Is immobility of rats in the forced swim test “behavioral despair?”

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Sexual dysfunction in depression

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Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders

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Modulating limbic-cortical circuits in depression: Targets of antidepressant treatments

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Effect of chronic treatment with imipramine on interleukin 1 and interleukin 2 production by splenocytes obtained from rats subjected to a chronic mild stress model of depression.

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The fallacy of behavioral phenotyping without standardisation

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Desmethylimipramine (DMI) counteracts learned helplessness in rats

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Social isolation after a single defeat reduces striatal dopamine transporter binding in rats

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Amino acid levels in depression: A preliminary investigation

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Impaired Lymphocyte Stimulation by Mitogens in Severely Depressed Patients

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Repeated Phencyclidine Treatment Induces Negative Symptom-like Behavior in Forced Swimming Test in Mice Imbalance of Prefrontal Serotonergic and Dopaminergic Functions

2000 • 95 citations

Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine

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Endocrine Profile and Neuroendocrine Challenge Tests in Transgenic Mice Expressing Antisense RNA against the Glucocorticoid Receptor

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Altered regulation of the 5‐HT system in the brain of MAO‐A knock‐out mice

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Lower Sensitivity to Stress and Altered Monoaminergic Neuronal Function in Mice Lacking the NMDA Receptor ε4 Subunit

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Effects of Withdrawal from an Escalating Dose Schedule of d-Amphetamine on Sexual Behavior in the Male Rat

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Differential Effects of Prenatal Stress in Two Inbred Strains of Rats

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Effects of antidepressants and anticholinergics in a mouse “behavioral despair” test

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Brain Output Dysregulation Induced by Olfactory Bulbectomy: An Approximation in the Rat of Major Depressive Disorder in Humans?

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Mouse models for psychiatric disorders

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Neuroadaptations to chronic exposure to drugs of abuse: Relevance to depressive symptomatology seen across psychiatric diagnostic categories

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Genetic regulation of extracellular serotonin by 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) autoreceptors in different brain regions of the mouse.

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Harnessing the mouse to unravel the genetics of human disease

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The Human Genome Project and Its Impact on Psychiatry

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Reversal of helpless behavior by serotonin uptake blockers in rats

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In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs

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Behavioral screen for antidepressants: The effects of drugs and electroconvulsive shock on performance under a differential-reinforcement-of-low-rate schedule

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Differential effects of peripheral and central anosmia producing techniques on spontaneous behavior patterns

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Amphetamine withdrawal: A behavioral evaluation

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Neurochemical and behavioral alterations elicited by a chronic intermittent stressor regimen: implications for allostatic load

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Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat

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Effects of repeated fluoxetine and citalopram administration on cytokine release in C57BL/6 mice

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Behavioural phenotyping of mouse mutants

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Genetics and genomics of behavioral and psychiatric disorders

2003 • 73 citations

Attenuation of sucrose reinforcement in dopamine D₁ receptor deficient mice

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Influence of olfactory bulbectomy and subsequent imipramine treatment on 5‐hydroxytryptaminergic presynapses in the rat frontal cortex: behavioural correlates

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Genotype- and experience-dependent susceptibility to depressive-like responses in the forced-swimming test

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The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice

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Dexamethasone nonsuppression in transgenic mice expressing antisense RNA to the glucocorticoid receptor

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Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice

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Adaptation of cortical but not hippocampal NMDA receptors after chronic citalopram treatment

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Neonatal treatment with clomipramine increased immobility in the forced swim test: An attribute of animal models of depression

1992 • 70 citations

Chronic stress impairs rotarod performance in rats: implications for depressive state

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Overview of the past contributions of animal models and their changing place in psychiatry

2001 • 69 citations

Behavioral responses to social stress in noradrenaline transporter knockout mice: Effects on social behavior and depression

2002 • 69 citations

A pretest procedure reliably predicts performance in two animal models of inescapable stress

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AN ANIMAL MODEL OF ANHEDONIA

1992 • 68 citations

Operant learning and differential-reinforcement-of-low-rate 36-s responding in 5-HT1A and 5-HT1B receptor knockout mice

2003 • 68 citations

An exploratory factor analysis of the Tail Suspension Test in 12 inbred strains of mice and an F2 intercross

2003 • 66 citations

Effects of Antidepressant Drugs on Rats Bred for Low Activity in the Swim Test

1998 • 66 citations

Gender Differences in Learned Helplessness Behavior Are Influenced by Genetic Background

2000 • 66 citations

An in-vivo magnetic resonance imaging study of the olfactory bulbectomized rat model of depression

2000 • 64 citations

Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdala

2003 • 64 citations

Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1).

2002 • 64 citations

Behavioral despair in mice after prenatal stress

2000 • 63 citations

Region-specific dysregulation of allopregnanolone brain content in the olfactory bulbectomized rat model of depression

2003 • 63 citations

Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats.

1999 • 63 citations

Effect of mild chronic stress, as a model of depression, on the immunoreactivity of C57BL⧹6 mice

1998 • 63 citations

Interindividual differences in active and passive behaviors in the forced-swimming test: implications for animal models of psychopathology

1999 • 63 citations

Combining pindolol and paroxetine in an animal model of chronic antidepressant action—can early onset of action be detected?

1998 • 62 citations

Olfactory bulbectomy temporarily impairs Morris maze performance: An ACTH(4?9) analog accellerates return of function

1995 • 61 citations

A further exploration of the relationships between immune parameters and the HPA-axis activity in depressed patients

1991 • 61 citations

Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice.

2000 • 61 citations

Differential galanin receptor‐1 and galanin expression by 5‐HT neurons in dorsal raphé nucleus of rat and mouse: evidence for species‐dependent modulation of serotonin transmission

2003 • 61 citations

Use of the automated tail suspension test for the primary screening of psychotropic agents.

1987 • 60 citations

Are there gender differences in the temperature profile of mice after acute antidepressant administration and exposure to two animal models of depression?

2001 • 60 citations

Strain-specific effects of antidepressants on escape deficits induced by inescapable shock

1989 • 60 citations

How Do Antidepressants Work? Prospects for Genetic Analysis of Drug Mechanisms

1999 • 59 citations

Regional patterns of compensation following genetic deletion of either 5-hydroxytryptamine(1A) or 5-hydroxytryptamine(1B) receptor in the mouse.

2001 • 59 citations

Serotonergic hyperinnervation of the frontal cortex in an animal model of depression, the bulbectomized rat

1998 • 58 citations

Chronic mild stress and depressive disorder: a useful new model?

1997 • 58 citations

In vivo visualization of serotonin transporters in the human brain during fluoxetine treatment

1999 • 57 citations

Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study

2003 • 57 citations

Pharmacological effects of venlafaxine, a new antidepressant, given repeatedly, on the α 1 -adrenergic, dopamine and serotonin systems

1999 • 57 citations

Darting behavior: a quantitative movement pattern designed for discrimination and replicability in mouse locomotor behavior

2003 • 57 citations

Melatonin protects against the effects of chronic stress on sexual behaviour in male rats

2001 • 56 citations

A genetic mouse model of helplessness sensitive to imipramine

1996 • 55 citations

Potentiation of the time-dependent, antidepressant-induced changes in the agonistic behaviour of resident rats by the 5-HT1A receptor antagonist, WAY-100635

1997 • 55 citations

Evolutionary psychiatry. Adaptationist and nonadaptationist conceptualizations

2002 • 55 citations

Influence of a natural stressor (predator odor) on locomotor activity in the meadow vole (Microtus pennsylvanicus): modulation by sex, reproductive condition and gonadal hormones

2000 • 52 citations

Repeated Injections of Interferon-α A/D in Balb/c Mice: Behavioral Effects

1993 • 52 citations

Prevalence, recognition, and treatment of comorbid depression and anxiety.

2001 • 52 citations

Withdrawal from chronic morphine administration causes prolonged enhancement of immobility in rat forced swimming test

2001 • 52 citations

Ventricular enlargement and caudate hyperdensity in elderly depressives

1991 • 51 citations

Chronic Stress Effects on Sexual Behavior in Male and Female Rats

1998 • 51 citations

Sex Differences in Mesolimbic Dopamine Responses to Ethanol and Relationship to Ethanol Intake in Rats

2002 • 51 citations

Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats

2000 • 51 citations

Enhancement of immobility in mouse forced swimming test by treatment with human interferon

1998 • 50 citations

Susceptibility and resistance of rats to stress-induced decreases in swim-test activity: a selective breeding study

1996 • 50 citations

Onset of the Effects of the 5-HT1A Antagonist, WAY-100635, Alone, and in Combination With Paroxetine, on Olfactory Bulbectomy and 8-OH-DPAT–Induced Changes in the Rat

1999 • 50 citations

Exposure to chronic mild stress alters thresholds for lateral hypothalamic stimulation reward and subsequent responsiveness to amphetamine

2002 • 49 citations

Stressor-induced alterations in serotonergic activity in an animal model of depression

1999 • 49 citations

Reduced attention in mice overproducing corticotropin-releasing hormone

2003 • 48 citations

Occupancy of the serotonin transporter by fluoxetine, paroxetine, and sertraline: In vivo studies with [¹²⁵i]rti‐55

1994 • 48 citations

Dissociation of multiple behavioral effects between olfactory bulbectomized C57B1/6J and DBA/2J mice

1992 • 48 citations

A chronic treatment with fluoxetine decreases 5-HT1A receptors labeling in mice selected as a genetic model of helplessness

2002 • 48 citations

Chronic mild stress-induced reductions in saccharin intake depend upon feeding status

1997 • 47 citations

Reduction of depressive-like behavior in mice lacking angiotensinogen

1999 • 47 citations

Role of Aversively Motivated Behavior in the Olfactory Bulbectomy Syndrome

1999 • 46 citations

Olfactory bulbectomy enhances sensitization of the acoustic startle reflex produced by acute or repeated stress.

1997 • 46 citations

Gender and gonadal hormone effects in the olfactory bulbectomy animal model of depression

2000 • 45 citations

ONTOGENIES IN MICE SELECTED FOR HIGH VOLUNTARY WHEEL-RUNNING ACTIVITY. I. MEAN ONTOGENIES

2003 • 45 citations

Effects of ramp shortening during linear phase of relaxation on [Ca²⁺]_iin intact skeletal muscle fibers

1999 • 44 citations

Olfactory bulbectomy enhances sensitization of the acoustic startle reflex produced by acute or repeated stress.

1997 • 44 citations

Hyperactivity of hypothalamic pituitary axis in neonatal clomipramine model of depression

1998 • 43 citations

The Reductions in Sweetened Milk Intake Induced by Interleukin-1 and Endotoxin Are Not Prevented by Chronic Antidepressant Treatment

2001 • 43 citations

Intravenous self-administration of amphetamine is increased in a rat model of depression

2002 • 43 citations

5-HT4 receptors do not mediate the antidepressant-like behavioral effects of fluoxetine in a modified forced swim test

2000 • 42 citations

Antidepressant drug exposure is associated with mRNA levels of tyrosine receptor kinase B in major depressive disorder

2000 • 42 citations

Amphetamine withdrawal does not produce a depressive-like state in rats as measured by three behavioral tests

2003 • 42 citations

Adenosine A2A receptor knockout mice are partially protected against drug-induced catalepsy

2001 • 41 citations

Bulbectomy-induced loss of raphe neurons is counteracted bt antidepressant treatment

1997 • 41 citations

Cholinergic blockade impairs performance in operant DNMTP in two inbred strains of mice

2002 • 41 citations

Interleukin-6 Involvement in Antidepressant Action of Hypericum Perforatum

2001 • 40 citations

Cocaine and SKF-82958 potentiate brain stimulation reward in Swiss-Webster mice

2002 • 39 citations

Autoradiographic distribution of cholinergic muscarinic receptors and serotonin₂ receptors in olfactory bulbectomized (OB) rats after chronic treatment with mianserin and desipramine

1994 • 39 citations

Influence of olfactory bulbectomy and the serotonergic system upon intermale aggression and maternal behavior in the mouse

1975 • 39 citations

Improved efficacy of fluoxetine in increasing hippocampal 5-hydroxytryptamine outflow in 5-HT1B receptor knock-out mice

2002 • 39 citations

Effects of fluoxetine and olfactory bulbectomy on mouse circadian activity rhythms

1996 • 37 citations

Prenatal ethanol exposure impairs lesion-induced plasticity in a dopaminergic synapse after maturity

1989 • 37 citations

Cerebral ventricular size and cognitive impairment in depression

1986 • 37 citations

An Investigation of Serotonergic Involvement in the Regulation of ACTH and Corticosterone in the Olfactory Bulbectomized Rat

1999 • 36 citations

Trans-NIH neuroscience initiatives on mouse phenotyping and mutagenesis

2001 • 35 citations

Effect of Chronic Administration of Antidepressants on α2-Adrenoceptors in the Locus Coeruleus and Its Projection Fields in Rat Brain Determined by Quantitative Autoradiography

1993 • 35 citations

Development of open‐field behavior in mice: Effects of age and experience

1968 • 34 citations

Reduced anxiety- and depression-like behaviors in Emx1 homozygous mutant mice

2002 • 33 citations

Selective breeding for increased cholinergic function: biometrical genetic analysis of muscarinic responses.

1992 • 33 citations

Effects of bulbectomy and subsequent antidepressant treatment on brain 5-HT2 and 5-HT1A receptors in mice

1993 • 33 citations

Changes in defensive behaviors following olfactory bulbectomy in male and female rats

2001 • 31 citations

Effects of bilateral olfactory bulbectomy on N‐methyl‐<scp>D</scp>‐aspartate receptor function: Autoradiographic and behavioral studies in the rat

2001 • 31 citations

Differential effects of olfactory bulbectomy on GABAA and GABAB receptors in the rat brain

1993 • 31 citations

An Evolutionary Approach to Psychiatry

2000 • 29 citations

The effects of selective serotonin reuptake inhibitors on extracellular 5-HT levels in the hippocampus of 5-HT1B receptor knockout mice

2002 • 29 citations

Divergent levels of anxiety in mice selected for differences in sensitivity to a convulsant agent

2000 • 29 citations

Olfactory bulbectomy increases prepro-enkephalin mRNA levels in the ventral striatum in rats

1999 • 28 citations

Anxiety associated with comorbid depression.

2002 • 28 citations

Clozapine promotes approach-oriented behavior in male mice.

1994 • 26 citations

Changes in Tonic Immobility and the GABA–Benzodiazepine System in Response to Handling in the Chick

1997 • 26 citations

Action of antidepressant drugs on maternal stress-induced hypoactivity in female rats

1999 • 26 citations

Escape deficits induced by uncontrollable foot-shock in recombinant inbred strains of mice

1993 • 26 citations

Selective breeding of 5-HT1A receptor-mediated responses: application to emotion and receptor action

2000 • 26 citations

Mouse Molecular Genetic Technologies

2001 • 26 citations

Repeated electroconvulsive shock attenuates the depressive-like effects of d-amphetamine withdrawal on brain reward function in rats

2001 • 24 citations

Tonic immobility in guinea pigs: A behavioural response for detecting an anxiolytic-like effect?

2002 • 24 citations

Congenitally learned helpless rats show abnormalities in intracellular signaling

2003 • 24 citations

Hierarchical strategy for phenotypic analysis in mice

1999 • 24 citations

Desipramine administration in the olfactory bulbectomized rat: changes in brain β‐adrenoceptor and 5‐HT_2A binding sites and their relationship to behaviour

1996 • 24 citations

Functional genomics approaches to understanding brain disorders

2002 • 24 citations

Hypertension and insulin resistant models have divergent propensities to learned helpless behavior in rodents

2000 • 22 citations

Precision in mouse behavior genetics

2001 • 21 citations

Decreased Number and Immunoreactivity of I₂‐Imidazoline Receptors in the Frontal Cortex of Suicide Victims^fn1

1995 • 20 citations

Is depression normal in human beings? A critique of the evolutionary perspective

2002 • 20 citations

Olfactory bulbectomy increases vasopressin, but not corticotropin-releasing hormone, content in the external layer of the median eminence of male rats

1999 • 18 citations

Changes in brain γ-aminobutyric acid concentrations following acute and chronic amphetamine administration and during post amphetamine depression

1978 • 16 citations

Enhancement of 5-hydroxytryptamine-induced head-twitch response after olfactory bulbectomy

2003 • 16 citations

Mouse lines differing in sensitivity to β-CCM differ in tasks used for testing antidepressants

2002 • 15 citations

Semiquantitative analysis of immunoreactivities of tyrosine hydroxylase and aromatic l-amino acid decarboxylase in the locus coeruleus of desipramine-treated mice

1992 • 14 citations

Correlation of nocturnal penile tumescence and daytime affect intensity in depressed men

1993 • 14 citations

Non-invasive, quantitative assessment of the anatomical phenotype of corticotropin-releasing factor-overexpressing mice by MRI

2001 • 14 citations

Difficult-to-Treat Depressions: A Primary Care Perspective

2003 • 14 citations

Chronic imipramine treatment upregulates IR2-imidazoline receptive sites in rat brain

1997 • 12 citations

Antidepressants suppress bulbectomy-induced augmentation of voluntary alcohol consumption in C57Bl/6j but not in DBA/2j mice

1994 • 12 citations

5-HT1B receptor knockout mice show no adaptive changes in 5-HT1A receptor function as measured telemetrically on body temperature and heart rate responses

2002 • 12 citations

Effects of Imipramine on T Cell Subsets in Olfactory Bulbectomized Mice

2002 • 10 citations

Comparison of two intracranial self-stimulation (ICSS) paradigms in C57BL/6 mice: head-dipping and place-learning

2001 • 8 citations

Biological Markers of Depression

2004 • 8 citations

Genetic Hyping

2000 • 6 citations

Effects of Bilateral Olfactory Bulbectomy on the Anterior Pituitary Corticotropic Cell Activity in Male Rats

1999 • 5 citations