The olfactory bulbectomized rat as a model of depression: An update

Depression: a new animal model sensitive to antidepressant treatments

1977 • 4,272 citations

The rat nervous system

1985 • 3,774 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Spatial localization does not require the presence of local cues

1981 • 2,665 citations

Psychopharmacology: The Third Generation of Progress.

1988 • 1,973 citations

Chemical Neuroanatomy

1984 • 1,646 citations

The validity of animal models of depression

1984 • 1,365 citations

Evidence for an immune response in major depression: A review and hypothesis

1995 • 954 citations

The Dexamethasone Suppression Test for Melancholia

1982 • 774 citations

Animal Model of Depression

1969 • 705 citations

Synaptic organization of the mammalian olfactory bulb

1972 • 691 citations

Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain

1975 • 599 citations

Tritiated Imipramine Binding Sites Are Decreased in Platelets of Untreated Depressed Patients

1980 • 440 citations

Spatial memory and radial arm maze performance of rats

1977 • 392 citations

Cholinergic and GABAergic afferents to the olfactory bulb in the rat with special emphasis on the projection neurons in the nucleus of the horizontal limb of the diagonal band

1986 • 382 citations

High-Affinity [ ³ H]Imipramine Binding in Rat Hypothalamus: Association with Uptake of Serotonin But Not of Norepinephrine

1980 • 378 citations

A Golgi study of the descending medial forebrain bundle

1969 • 343 citations

Glucocorticoids and the Genesis of Depressive Illness a Psychobiological Model

1994 • 338 citations

Neurochemistry of the vertebrate olfactory bulb

1983 • 337 citations

The axonal projection patterns of the mitral and tufted cells of the olfactory bulb in the rat

1977 • 334 citations

The projection of the auditory cortex upon the diencephalon and brain stem in the cat

1969 • 305 citations

Surprisingly rich projection from locus coeruleus to the olfactory bulb in the rat

1985 • 287 citations

Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression

1994 • 270 citations

Alterations in the N-methyl-d-asparatate (NMDA) receptor complex in the frontal cortex of suicide victims

1995 • 263 citations

Olfactory regulation of maternal behavior in rats: II. Effects of peripherally induced anosmia and lesions of the lateral olfactory tract in pup-induced virgins.

1974 • 249 citations

Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.

1994 • 241 citations

Anatomical, Physiological, and Behavioral Aspects of Olfactory Bulbectomy in The Rat

1981 • 218 citations

Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats

1990 • 216 citations

Central nervous system pharmacology of neuropeptide Y

1995 • 201 citations

Transmitter histochemistry of the rat olfactory bulb. I. Immunohistochemical localization of monoamine synthesizing enzymes. Support for intrabulbar, periglomerular dopamine neurons

1977 • 195 citations

Human brain receptor alterations in suicide victims

1982 • 179 citations

Central serotonergic responses and behavioural adaptation to repeated immobilisation: The effect of the corticosterone synthesis inhibitor metyrapone

1985 • 172 citations

Olfactory bulbectomy as a model for agitated hyposerotonergic depression

1992 • 170 citations

The role of the olfactory bulb in limbic mechanisms.

1974 • 167 citations

Olfactory bulb projections to the parahippocampal area of the rat

1981 • 159 citations

Mineral Metabolism in Melancholia

1963 • 157 citations

Benzodiazepines reduce the tolerance to reward delay in rats

1985 • 156 citations

Monoamine-related markers of depression: Changes following treatment

1982 • 153 citations

Secondary brain changes following lesions: A new paradigm for lesion experimentation

1977 • 151 citations

Demonstration of terminalis, olfactory, trigeminal and perivascular nerves in the rat nasal septum

1975 • 143 citations

Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls

1989 • 143 citations

Involvement of the amygdaloid complex in neuromodulatory influences on memory storage

1990 • 119 citations

Olfactory projection systems, drugs and behaviour: A review

1979 • 113 citations

5-HT_1A Receptor Sensitivity in Major Depression

1994 • 103 citations

Effects of imipramine-like drugs and serotonin uptake blockers on delay of reward in rats. Possible implication in the behavioral mechanism of action of antidepressants.

1988 • 96 citations

PUTATIVE TRANSMITTERS IN DENERVATED OLFACTORY CORTEX

1975 • 95 citations

Development of histamine‐immunoreactive neurons in the rat brain

1988 • 89 citations

Effects of olfactory bulbectomy and domicile on stress-induced corticosterone release in the rat

1977 • 89 citations

Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation.

1993 • 86 citations

Brain Output Dysregulation Induced by Olfactory Bulbectomy: An Approximation in the Rat of Major Depressive Disorder in Humans?

1988 • 86 citations

The effect of tianeptine and sertraline in three animal models of depression

1994 • 86 citations

Changes in neurotransmitter metabolism following olfactory bulbectomy in the rat

1984 • 84 citations

Differential effects of peripheral and central anosmia producing techniques on spontaneous behavior patterns

1974 • 80 citations

Effects of buspirone on plasma prolactin and cortisol levels in major depressed and normal subjects

1994 • 80 citations

THE INCREASE IN THE TOXICITY OF YOHIMBINE INDUCED BY IMIPRAMINE AND OTHER DRUGS IN MICE

1963 • 79 citations

Impaired Mating Performances in Male Rats after Anosmia Induced Peripherally or Centrally

1971 • 79 citations

The role of the olfactory system in avoidance learning and activity

1972 • 78 citations

The Platelet Serotonergic System in Depression and Following Sertraline Treatment

1988 • 74 citations

Neutrophil and monocyte phagocytosis in depressed patients

1993 • 72 citations

Taste-potentiated odor aversion learning: Role of the amygdaloid basolateral complex and central nucleus.

1992 • 71 citations

Exploratory behavior and spontaneous alternation in blind and anosmic rats.

1969 • 66 citations

Effects of olfactory bulb ablation upon emotionality and muricidal behavior in four rat strains.

1973 • 64 citations

Olfactory bulbectomy temporarily impairs Morris maze performance: An ACTH(4?9) analog accellerates return of function

1995 • 61 citations

Elevated Plasma Concentrations of α1-Acid Glycoprotein, a Putative Endogenous Inhibitor of the Tritiated Imipramine Binding Site, in Depressed Patients

1990 • 60 citations

Lessons from lesions: the effects of olfactory bulbectomy

1992 • 57 citations

Corticosterone, choline acetyltransferase and noradrenaline levels in olfactory bulbectomized rats in relation to changes in passive avoidance acquisition and open field activity

1986 • 57 citations

A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINE

1964 • 55 citations

Olfactory bulbectomy impairs the rat's radial-maze behavior☆

1983 • 54 citations

Detection of propionic acid vapor by rats with lesions of olfactory bulb areas associated with high 2-DG uptake

1987 • 52 citations

The Vertebrate Olfactory System

1990 • 51 citations

Abnormal zymosan-induced neutrophil chemiluminescence as a marker of depression

1990 • 50 citations

Enhancement of conditioned taste aversions by lesions of the midbrain raphe nuclei that deplete serotonin

1977 • 49 citations

The vertebrate olfactory system

1991 • 48 citations

Olfactory bulb removal decreases androgen receptor binding in amygdala and hypothalamus and disrupts masculine sexual behavior

1987 • 48 citations

The effect of olfactory bulbectomy in the rat, alone or in combination with antidepressants and endogenous factors, on immune function

1995 • 48 citations

The effects of fluoxetine and zimeldine on the behavior of olfactory bulbectomized rats

1986 • 44 citations

Catalase, Superoxide Dismutase and Glutathione Peroxidase Activity in Neutrophils of Sham-Operated and Olfactory-Bulbectomised Rats following Chronic Treatment with Desipramine and Lithium Chloride

1994 • 42 citations

Pathways linking the olfactory bulbs with the medial preoptic anterior hypothalamus are important for intermale aggression in mice

1993 • 41 citations

Serotonin reuptake inhibitors reverse the impairments in behaviour, neurotransmitter and immune functions in the olfactory bulbectomized rat

1994 • 40 citations

The neurochemical sequelae of olfactory bulbectomy

1980 • 40 citations

Antidepressant-induced modulation of GABAA receptors and β-adrenoceptors but not GABAB receptors in the frontal cortex of olfactory bulbectomised rats

1994 • 40 citations

Autoradiographic distribution of cholinergic muscarinic receptors and serotonin₂ receptors in olfactory bulbectomized (OB) rats after chronic treatment with mianserin and desipramine

1994 • 39 citations

Possible relationship between neuropeptide Y (NPY) and major depression – evidence from human and animal studies

1988 • 39 citations

The chronic effects of desipramine and sertraline on platelet and synaptosomal 5HT uptake in olfactory bulbectomised rats

1988 • 39 citations

Sensory reinnervation after partial removal of the olfactory bulb

1992 • 38 citations

Amino acid transmitter candidates in various regions of the primary olfactory cortex following bulbectomy

1984 • 35 citations

Platelet peripheral-type benzodiazepine receptor in major depression

1995 • 33 citations

Antidepressants: Thirty Years On

1994 • 32 citations

Differential effects of olfactory bulbectomy on GABAA and GABAB receptors in the rat brain

1993 • 31 citations

Levels and Synthesis of Glutamate and Aspartate in the Olfactory Cortex Following Bulbectomy

1983 • 31 citations

Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity

1991 • 29 citations

The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking

1992 • 27 citations

Selective retrograde transport of tritiated d-aspartate from the olfactory bulb to the anterior olfactory nucleus, pyriform cortex and nucleus of the lateral olfactory tract in the rat

1984 • 25 citations

The effects of antidepressant drugs on conditioned taste aversion learning of the olfactory bulbectomized rat.

1981 • 24 citations

Detection of Aggregated Leukocytes in the Circulating Pool during Stress – Demargination Is Not Necessarily a Result of Decreased Leukocyte Adhesiveness

1991 • 23 citations

Sleep-wskefulness rhythms in the olfactory bulb lesioned rats

1976 • 22 citations

Effect of olfactory bulbectomy and chronic amitryptiline treatment in rats. 3H-imipramine binding and behavioral analysis by swimming and open field tests

1988 • 22 citations

Effectiveness of Recombinant Human Erythropoietin Therapy in Myelodysplastic Syndromes

1992 • 22 citations

Effects of imipramine on the nocturnal behavior of bilateral olfactory bulbectomized rats

1991 • 21 citations

Enhancement of NMDA receptor-mediated synaptic potential evoked in rat medial-amygdala neuron following olfactory bulbectomy

1990 • 20 citations

Women and Epilepsy

1992 • 19 citations

EFFECTS OF P-CHLOROPHENYLALANINE (P-CPA) ON SLEEP IN OLFACTORY BULB LESIONED RATS

1977 • 17 citations

Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats

1986 • 17 citations

Basal plasma corticosterone level after bilateral selective lesions of thee olfactory pathways in the rat

1986 • 15 citations

Bulbectomy and sensitivity to estrogen: Anatomical and functional specificity

1980 • 15 citations

Differential effects of antidepressant drugs on [3H]dihydroalprenolol and [3H]imipramine ligand recognition sites in olfactory bulbectomized and sham-lesioned rats

1986 • 15 citations

Effects of olfactory bulbectomy and peripherallyinduced anosmia on thermoregulation in the rat: susceptibility to antidepressant type drugs

1980 • 15 citations

Role of central α2-adrenoceptors on the development of muricidal behavior in olfactory bulbectomized rats: Effect of α2-adrenoceptor antagonists

1987 • 14 citations

Quantitative autoradiographic studies of the effects of bilateral olfactory bulbectomy in the rat brain: Central- and peripheral-type benzodiazepine receptors

1994 • 13 citations

Antidepressants reverse the olfactory bulbectomy-induced decreases in splenic peripheral-type benzodiazepine receptors in rats

1995 • 12 citations

Olfactory bulbectomy alters alpha-1 acid glycoprotein levels in rat plasma

1990 • 12 citations

Is the state of leucocyte adhesiveness/aggregation an immune marker of stress in the olfactory bulbectomized rat?

1993 • 11 citations

Effects of chronic desipramine on waiting behaviour for a food reward in olfactory bulbectomized rats

1996 • 11 citations

Olfactory bulbectomy increases basal suprachiasmatic cyclic AMP levels in male rats

1991 • 11 citations

The effects of olfactory system lesions and food deprivation on spontaneous behavior patterns of male hooded rats

1973 • 9 citations

Effects of restraint stress on plaque-forming cell response in normal and olfactory bulbectomized mice

1991 • 6 citations

Comparison of the effects of benzodiazepine and nonbenzodiazepine anxiolytics on mouse-killing behavior in rats.

1988 • 6 citations

Effect of some new antidepressant on learned helplessness and olfactory bulbectomy models of depression

1990 • 5 citations

Changes in [3H]-imipramine binding sites in relation to muricide following olfactory bulbectomy and the effect of nomifensine in brain of rats.

1988 • 4 citations

Some behavioural and neurochemical effects of ipsapirone in two rodent models of depression

1996 • 4 citations

Circadian hormonal profiles and sleep in affective disorders

1994 • 3 citations

Behavioural responses to olfactory bulbectomy in rats maintained in reversed cycle lighting

1993 • 2 citations

Deleted Work

1955 • 0 citations