Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders

Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States

1994 • 12,456 citations

The Emotional Brain: The Mysterious Underpinnings of Emotional Life

2004 • 4,130 citations

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

1997 • 3,131 citations

A review of central 5-HT receptors and their function

1999 • 3,121 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

Lifetime Co-occurrence of DSM-III-R Alcohol Abuse and Dependence With Other Psychiatric Disorders in the National Comorbidity Survey

1997 • 2,048 citations

Pituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood

2000 • 1,925 citations

Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat

1999 • 1,909 citations

Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats

1993 • 1,626 citations

Genetics of Mouse Behavior: Interactions with Laboratory Environment

1999 • 1,626 citations

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

1986 • 1,509 citations

Reliability and Validity

1986 • 1,422 citations

Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat

1998 • 1,410 citations

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

1997 • 1,362 citations

The Epidemiology of Obsessive-Compulsive Disorder in Five US Communities

1988 • 1,323 citations

Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality.

1934 • 1,281 citations

Childhood trauma in borderline personality disorder

1989 • 1,241 citations

A review of the validity and variability of the Elevated Plus-Maze as an animal model of anxiety

1996 • 1,160 citations

Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study

2000 • 1,097 citations

The neuroanatomical and neurochemical basis of conditioned fear

1999 • 1,092 citations

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

1988 • 1,068 citations

Neural organization of the defensive behavior system responsible for fear

1994 • 968 citations

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

1996 • 895 citations

Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60

1996 • 883 citations

Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder

1987 • 855 citations

A comparison of exposure therapy, stress inoculation training, and their combination for reducing posttraumatic stress disorder in female assault victims.

1999 • 851 citations

Ethologically-based animal models of anxiety disorders

1990 • 841 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs

1980 • 813 citations

Serotonin receptor 1A knockout: An animal model of anxiety-related disorder

1998 • 802 citations

The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat

1960 • 785 citations

A comparison of exposure therapy, stress inoculation training, and their combination for reducing posttraumatic stress disorder in female assault victims.

1999 • 754 citations

Fear-potentiated startle: A neural and pharmacological analysis

1993 • 736 citations

Contextual control of the extinction of conditioned fear: Tests for the associative value of the context.

1983 • 732 citations

Long-term behavioral and neuroendocrine adaptations to adverse early experience

2000 • 707 citations

Elevated anxiety and antidepressant-like responses in serotonin 5-HT _1A receptor mutant mice

1998 • 690 citations

Increased anxiety of mice lacking the serotonin _1A receptor

1998 • 684 citations

Efficacy and Safety of Sertraline Treatment of Posttraumatic Stress Disorder

2000 • 676 citations

Animal models in psychiatry and neurology

1978 • 648 citations

Sex differences in animal tests of anxiety

1991 • 576 citations

Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder

1990 • 546 citations

Exploration of mice in a black and white test box: Validation as a model of anxiety

1989 • 535 citations

DSM-IV field trial: obsessive-compulsive disorder [published erratum appears in Am J Psychiatry 1995 Apr;152(4):654]

1995 • 522 citations

Stress-restress: Effects on ACTH and fast feedback

1997 • 497 citations

5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research

1995 • 497 citations

Amygdala response to facial expressions in children and adults

2001 • 473 citations

The Developmental Impact of Different Forms of Child Abuse and Neglect

1995 • 464 citations

Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP

2000 • 442 citations

Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli

1999 • 435 citations

Conditioned defensive burying: A new paradigm for the study of anxiolytic agents

1981 • 425 citations

5-HT1A receptor-related anxiolytics

1987 • 402 citations

Rodent sex differences in emotional and related behavior

1975 • 390 citations

A Primary Acoustic Startle Pathway: Obligatory Role of Cochlear Root Neurons and the Nucleus Reticularis Pontis Caudalis

1996 • 370 citations

Localized Orbitofrontal and Subcortical Metabolic Changes and Predictors of Response to Paroxetine Treatment in Obsessive-Compulsive Disorder

1999 • 361 citations

Defense system psychopharmacology: An ethological approach to the pharmacology of fear and anxiety

1993 • 359 citations

Sex differences in depression: a role for preexisting anxiety

1995 • 358 citations

Gender differences in the epidemiology and treatment of anxiety disorders.

1999 • 343 citations

Major depression and generalised anxiety disorder. Same genes, (partly)different environments--revisited.

1996 • 341 citations

The Ontogeny of the Hypothalamic‐Pituitary‐Adrenal Axis. The Influence of Maternal Factorsa

1994 • 341 citations

Regional brain function, emotion and disorders of emotion

1999 • 338 citations

The empirical basis of generalized anxiety disorder

1994 • 315 citations

Role of the amygdala and periaqueductal gray in anxiety and panic

1993 • 303 citations

Differential Regulation of Hippocampal Glucocorticoid Receptors mRNA and Fast Feedback: Relevance to Post‐Traumatic Stress Disorder

1999 • 299 citations

Generalized Social Phobia

1995 • 289 citations

Panic Attacks in the Community

1991 • 282 citations

Neonatal endotoxin exposure alters the development of the hypothalamic- pituitary-adrenal axis: early illness and later responsivity to stress

1995 • 275 citations

Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries

1997 • 275 citations

Roles of the Amygdala and Bed Nucleus of the Stria Terminalis in Fear and Anxiety Measured with the Acoustic Startle Reflex

1997 • 275 citations

5′-Heterogeneity of Glucocorticoid Receptor Messenger RNA Is Tissue Specific: Differential Regulation of Variant Transcripts by Early-Life Events

2000 • 248 citations

Pharmacotherapy for Posttraumatic Stress Disorder Using Phenelzine or Imipramine

1991 • 243 citations

Second-order fear conditioning prevented by blocking NMDA receptors in amygdala

1997 • 243 citations

Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior

1997 • 236 citations

Normal conditioning inhibition and extinction of freezing and fear-potentiated startle following electrolytic lesions of medial prefrontal cortex in rats.

1997 • 225 citations

Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

1999 • 216 citations

The Effects of Varying Environmental Demands on Maternal and Infant Behavior

1984 • 213 citations

Animal models in psychiatry and neurology

1977 • 213 citations

Posttraumatic stress disorder: epidemiology and health-related considerations.

2000 • 202 citations

The effects of neonatal stress on brain development: Implications for psychopathology

1999 • 193 citations

The Effects of Varying Environmental Demands on Maternal and Infant Behavior

1984 • 193 citations

Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses

1999 • 189 citations

Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety.

2000 • 184 citations

Treatment of separation anxiety in dogs with clomipramine: results from a prospective, randomized, double-blind, placebo-controlled, parallel-group, multicenter clinical trial

2000 • 175 citations

5-HT receptors as targets for the development of novel anxiolytic drugs: models, mechanisms and future directions

1993 • 168 citations

Cross‐species Studies of Sensorimotor Gating of the Startle Reflex

1999 • 156 citations

5'-Heterogeneity of Glucocorticoid Receptor Messenger RNA Is Tissue Specific: Differential Regulation of Variant Transcripts by Early-Life Events

2000 • 152 citations

Sex effects in defensive behavior: Baseline differences and drug interactions

1991 • 148 citations

Consequences of physical abuse and neglect in children

1986 • 145 citations

The anxiety and depressive disorders: Descriptive psychopathology and differential diagnosis.

1989 • 137 citations

The effects of benzodiazepines and serotonergic manipulations on punished responding

1979 • 136 citations

Animal Models for Anxiety and Response to Serotonergic Drugs

1989 • 135 citations

Neural Systems Involved in Fear‐Potentiated Startle

1989 • 132 citations

Current treatments of the anxiety disorders in adults

1999 • 131 citations

Is the Course of Panic Disorder the Same in Women and Men?

1998 • 129 citations

Feelings of parental caring predict health status in midlife: a 35-year follow-up of the Harvard Mastery of Stress Study.

1997 • 126 citations

Dissection of behavior and psychiatric disorders using the mouse as a model

2000 • 123 citations

Sex differences and stress response of WKY rats

1993 • 117 citations

Blockade of GABAA receptors in the region of the anterior basolateral amygdala of rats elicits increases in heart rate and blood pressure

1991 • 111 citations

DSM-III-R criteria for posttraumatic stress disorder

1988 • 108 citations

Changes in burying behavior during the estrous cycle: Effect of estrogen and progesterone

1992 • 104 citations

Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions

1996 • 103 citations

Sex differences in the incidence and sonographic characteristics of antipredator ultrasonic cries in the laboratory rat (Rattus norvegicus).

1992 • 102 citations

Hippocampal lesions interfere with Pavlovian negative occasion setting

1999 • 99 citations

Excitatory amino acid receptor antagonists block the cardiovascular and anxiety responses elicited by gamma-aminobutyric acidA receptor blockade in the basolateral amygdala of rats.

1997 • 95 citations

Effects of treatment with imipramine and clonazepam on an animal model of panic disorder

1994 • 94 citations

Forebrain mechanisms in the relief of fear: The role of the lateral septum

1988 • 92 citations

Dorsomedial hypothalamic GABA regulates anxiety in the social interaction test

1995 • 87 citations

Selective serotonin reuptake inhibitors in post-traumatic stress disorder

2000 • 82 citations

The Role of Nutrition in the Physiological and Behavioral Effects of Early Maternal Separation on Infant Rats

1973 • 82 citations

The circumventricular organs form a potential neural pathway for lactate sensitivity: implications for panic disorder.

1997 • 82 citations

Spatial aversion conditioning with ethanol

1981 • 81 citations

Gender bias in the preclinical psychopharmacology of anxiety: male models for (predominantly) female disorders

1995 • 80 citations

Benzodiazepine and Serotonergic Modulation of Antipredator and Conspecific Defense

1998 • 80 citations

The Circumventricular Organs Form a Potential Neural Pathway for Lactate Sensitivity: Implications for Panic Disorder

1997 • 79 citations

A model of ???antipredator??? defense in Swiss-Webster mice

1995 • 78 citations

Priming of experimental anxiety by repeated subthreshold GABA blockade in the rat amygdala

1995 • 77 citations

Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission

1999 • 72 citations

Methods for Assessing the Validity of Animal Models of Human Psychopathology

2003 • 71 citations

Discriminative stimulus control by the anxiogenic ß-carboline FG 7142: Generalization to a physiological stressor

1988 • 69 citations

Panic attacks in the community. Social morbidity and health care utilization

1991 • 67 citations

Benzodiazepine receptors in the periaqueductal grey mediate anti-aversive drug action

1984 • 67 citations

Predator-elicited plight responses in Swiss-Webster Mice: An experimental model of panic attacks

1996 • 66 citations

Sodium lactate elicits anxiety in rats after repeated GABA receptor blockade in the basolateral amygdala

2000 • 65 citations

A Paradoxical Locomotor Response in Serotonin 5-HT_2CReceptor Mutant Mice

2000 • 62 citations

Defensive attack behavior in male and female rats

1980 • 60 citations

Mouse models of serotonin receptor function: toward a genetic dissection of serotonin systems

2000 • 57 citations

Do panic disorder and posttraumatic stress disorder share a common psychoneuroendocrinology?

1999 • 57 citations

Measurement of Anxiety in Transgenic Mice

2000 • 54 citations

Pituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood

2001 • 53 citations

Chlordiazepoxide and GABA injected into raphé dorsalis release the conditioned behavioural suppression induced in rats by a conflict procedure without nociceptive component

1980 • 53 citations

Behavioral pharmacology of antagonists at 5-HT2/5-HT1C receptors

1992 • 52 citations

Current concepts in the treatment of panic disorder.

1999 • 51 citations

Role of the Basolateral Amygdala in Panic Disorder

1999 • 48 citations

Clinical Neuroendocrinology

1978 • 48 citations

Ultrasounds during agonistic interactions between female rats (Rattus norvegicus).

1993 • 48 citations

Use of clomipramine to treat ritualistic stereotypic motor behavior in three dogs

1994 • 47 citations

Hypothalamic Mechanisms and the Cardiovascular Response to Stress

1992 • 36 citations

Animal models sensitive to anti‐anxiety agents

1998 • 35 citations

Stretched-approach sequences directed at a localized shock source by Rattus norvegicus..

1989 • 31 citations

Animal models of anxiety

1981 • 31 citations

Drug discrimination models in anxiety and depression

1990 • 30 citations

Anxiety Disorders in Women: Gender-Related Modulation of Neurobiology and Behavior

1997 • 29 citations

Inhibition of fear-potentiated startle can be detected after the offset of a feature trained in a serial feature-negative discrimination.

1997 • 28 citations

The DSM-IV panic disorder field trial: Panic attack frequency and functional disability

1996 • 27 citations

Inhibition of fear-potentiated startle can be detected after the offset of a feature trained in a serial feature-negative discrimination.

1997 • 23 citations

Behavioral effects of oral yohimbine in differentially reared nonhuman primates.

1992 • 21 citations

Longitudinal studies of genetically nervous dogs.

1977 • 16 citations

Neuroimaging Findings in Anxiety Disorders.

1996 • 15 citations

The Neurobiology and Treatment of Obsessive–Compulsive Disorder

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Comparison of RDC, DSM-III, DSM-III-R diagnostic criteria for generalized anxiety disorder

1996 • 7 citations

Stretched-approach sequences directed at a localized shock source by Rattus norvegicus.

1989 • 2 citations

Comparison of RDC, DSM‐III, DSM‐III‐R diagnostic criteria for generalized anxiety disorder

1996 • 1 citations

Deleted Work

1955 • 0 citations