Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels

Depression: a new animal model sensitive to antidepressant treatments

1977 • 4,272 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

The validity of animal models of depression

1984 • 1,365 citations

International Union of Pharmacology nomenclature of adrenoceptors.

1994 • 1,173 citations

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988 • 1,053 citations

Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.

1987 • 630 citations

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

1988 • 578 citations

Application of high performance liquid chromatography with electrochemical detection to neurochemical analysis: measurement of catecholamines, serotonin and metabolites in rat brain

1981 • 524 citations

Central Hypotensive Effects of the α _2a -Adrenergic Receptor Subtype

1996 • 484 citations

Cardiovascular Regulation in Mice Lacking α ₂ -Adrenergic Receptor Subtypes b and c

1996 • 463 citations

Distributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization study

1993 • 458 citations

Distribution of α2-adrenergic receptor subtype gene expression in rat brain

1994 • 423 citations

The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments

1997 • 397 citations

Substitution of a mutant α _2a -adrenergic receptor via “hit and run” gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

1997 • 354 citations

Distribution of ?2C-adrenergic receptor-like immunoreactivity in the rat central nervous system

1996 • 351 citations

The distribution and significance of CNS adrenoceptors examined with in situ hybridization

1996 • 298 citations

Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression.

1997 • 298 citations

Loss of Glucocorticoid Fast Feedback in Depression

1991 • 297 citations

The α_2aAdrenergic Receptor Subtype Mediates Spinal Analgesia Evoked by α₂Agonists and Is Necessary for Spinal Adrenergic–Opioid Synergy

1997 • 275 citations

Pharmacologic and Therapeutic Applications of alpha2-Adrenoceptor Subtypes

1993 • 225 citations

Subtype-Specific Intracellular Trafficking of α₂-Adrenergic Receptors

1997 • 181 citations

Adrenergic α_2C-Receptors Modulate the Acoustic Startle Reflex, Prepulse Inhibition, and Aggression in Mice

1998 • 178 citations

Genetic Alteration of α_2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α₂-Adrenoceptor Agonist

1997 • 165 citations

Subtype-specific differences in the intracellular sorting of G protein-coupled receptors.

1993 • 149 citations

Adrenergic receptors mediate changes in c-fos mRNA levels in brain

1989 • 126 citations

Activation of the Locus Ceruleus Brain Noradrenergic System during Stress: Circuitry, Consequences, and Regulation

1997 • 118 citations

Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative

1988 • 118 citations

Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog.

1995 • 116 citations

EXPRESSION OF α 2 -ADRENERGIC RECEPTOR SUBTYPES IN THE MOUSE BRAIN: EVALUATION OF SPATIAL AND TEMPORAL INFORMATION IMPARTED BY 3 kb OF 5′ REGULATORY SEQUENCE FOR THE α 2A AR-RECEPTOR GENE IN TRANSGENIC ANIMALS

1996 • 110 citations

Brain α-adrenoceptors in depressed suicides

1997 • 106 citations

In vivo electrophysiological evidence for tonic activation by endogenous noradrenaline of α2-adrenoceptors on 5-hydroxytryptamine terminals in the rat hippocampus

1993 • 102 citations

Antisense to the glucocorticoid receptor in hippocampal dentate gyrus reduces immobility in forced swim test

1996 • 97 citations

Coinjection strategy for visual identification of transgenic mice

1991 • 94 citations

Evaluation of the effects of a specific α2-adrenoceptor antagonist, atipamezole, on α1- and α2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine

1997 • 83 citations

Alterations in the central nervous α2-adrenoceptor system under chronic psychosocial stress

1996 • 82 citations

Corticosterone influences forced swim-induced immobility

1994 • 79 citations

d-amphetamine and l-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the α2C-adrenergic receptor subtype

1998 • 79 citations

Effects of atipamezole, a novel α2-adrenoceptor antagonist, in open-field, plus-maze, two compartment exploratory, and forced swimming tests in the rat

1991 • 46 citations

Clonidine as a sensitizing agent in the forced swimming test for revealing antidepressant activity.

1991 • 46 citations

α2-adrenoceptor blockade prevents the effect of desipramine in the forced swimming test

1990 • 36 citations

Functions Mediated by alpha-2 Adrenergic Receptors

1988 • 34 citations

Improved high-performance liquid chromatographic method for the routine determination of unconjugated 3-methoxy-4-hydroxyphenylethyleneglycol in human plasma using solid-phase extraction and electrochemical detection

1991 • 9 citations