Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects

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1978 • 5,735 citations

A Specific Laboratory Test for the Diagnosis of Melancholia

1981 • 2,238 citations

The Family History Method Using Diagnostic Criteria

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Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

Disrupted 24-hour Patterns of Cortisol Secretion in Psychotic Depression

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Psychopharmacology: The Fourth Generation of Progress

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Comprehensive Textbook of Psychiatry

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Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

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The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders

1994 • 663 citations

Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients

1994 • 657 citations

Corticotropin-releasing factor, norepinephrine, and stress

1999 • 623 citations

Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims

1988 • 547 citations

Alterations in corticotropin-releasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress

1986 • 466 citations

Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression

1997 • 424 citations

Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus

1990 • 400 citations

Stress-Induced Norepinephrine Release in the Hypothalamic Paraventricular Nucleus and Pituitary-Adrenocortical and Sympathoadrenal Activity: In Vivo Microdialysis Studies

1995 • 394 citations

CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia

1987 • 339 citations

Amygdaloid Corticotropin‐Releasing Factor Targets Locus Coeruleus Dendrites: Substrate for the Co‐ordination of Emotional and Cognitive Limbs of the Stress Response

1998 • 303 citations

Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events

2001 • 289 citations

Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression

1993 • 277 citations

Neuropeptide Concentrations in the Cerebrospinal Fluid of Depressed Patients Treated with Electroconvulsive Therapy

1991 • 253 citations

Corticotropin-Releasing Factor : Basic and Clinical Studies of a Neuropeptide

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Activation of noradrenergic locus coeruleus neurons by hemodynamic stress is due to local release of corticotropin-releasing factor

1991 • 247 citations

Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment

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Corticotropin-releasing factor innervation of the locus coeruleus region: Distribution of fibers and sources of input

1992 • 219 citations

Elevated CSF CRF in suicide victims

1989 • 204 citations

Corticotropin-releasing hormone in depression and post-traumatic stress disorder

2001 • 201 citations

Corticotropin-releasing factor-containing axon terminals synapse onto catecholamine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus coeruleus in the rat brain

1996 • 197 citations

Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders

2001 • 194 citations

Corticotropin‐Releasing Factor Stimulates Catecholamine Release in Hypothalamus and Prefrontal Cortex in Freely Moving Rats as Assessed by Microdialysis

1993 • 179 citations

Involvement of corticotropin-releasing factor in chronic stress regulation of the brain noradrenergic system.

1991 • 171 citations

Psychological stress increased corticotropin-releasing hormone mRNA and content in the central nucleus of the amygdala but not in the hypothalamic paraventricular nucleus in the rat

1999 • 162 citations

Branching projections of catecholaminergic brainstem neurons to the paraventricular hypothalamic nucleus and the central nucleus of the amygdala in the rat

1993 • 161 citations

Molecular control of locus coeruleus neurotransmission

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Elevated Tyrosine Hydroxylase in the Locus Coeruleus of Suicide Victims

1994 • 146 citations

Coordinate Regulation of the Cyclic AMP System with Firing Rate and Expression of Tyrosine Hydroxylase in the Rat Locus Coeruleus: Effects of Chronic Stress and Drug Treatments

1992 • 133 citations

Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression

1999 • 133 citations

Locus coeruleus activation by colon distention: role of corticotropin-releasing factor and excitatory amino acids

1997 • 132 citations

Immunocytochemical evidence for stimulatory control by the ventral noradrenergic bundle of parvocellular neurons of the paraventricular nucleus secreting corticotropin releasing hormone and vasopressin in rats

1986 • 129 citations

Evidence for divergent projections to the brain noradrenergic system and the spinal parasympathetic system from Barrington's nucleus

1996 • 119 citations

Corticotropin-releasing factor administered into the locus coeruleus, but not the parabrachial nucleus, stimulates norepinephrine release in the prefrontal cortex

1995 • 109 citations

Pharmacology and Distribution of Norepinephrine Transporters in the Human Locus Coeruleus and Raphe Nuclei

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Acetylcholine and Norepinephrine Stimulate the Release of Corticotropin-Releasing Factor-41 from the Rat Hypothalamusin Vitro*

1988 • 108 citations

Low cerebrospinal fluid corticotropin-releasing hormone concentrations in eucortisolemic depression

1997 • 104 citations

Previous stress alters corticotropin-releasing factor neurotransmission in the locus coeruleus

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Discrete local application of corticotropin-releasing factor increases locus coeruleus discharge and extracellular norepinephrine in rat hippocampus

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Hypothalamic-pituitary-adrenal axis function and suicidal behavior in depression

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Pharmacological comparison of two corticotropin-releasing factor antagonists: in vivo and in vitro studies.

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Long-term regulation of locus ceruleus sensitivity to corticotropin-releasing factor by swim stress.

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HPA-related CSF neuropeptides in suicide attempters

1992 • 80 citations

Chronic cold exposure potentiates CRH-evoked increases in electrophysiologic activity of locus coeruleus neurons

2001 • 67 citations

Stress-Induced Norepinephrine Release in the Paraventricular Nucleus of Rats with Brainstem Hemisections: A Microdialysis Study

1993 • 59 citations

Corticotropin-releasing factor receptor antagonist infused into the locus coeruleus attenuates immobilization stress-induced defensive withdrawal in rats

1996 • 58 citations

Behavioral Effects of Corticotropin-Releasing Factor

1990 • 56 citations

Effects of electroconvulsive therapy on the CRH-ACTH-cortisol system in melancholic depression: preliminary findings.

1994 • 52 citations

Decreased corticotropin-releasing hormone (CRH) concentrations in the cerebrospinal fluid of eucortisolemic suicide attempters

2001 • 51 citations

Corticotropin-releasing factor binding sites in cortex of depressed suicides

1997 • 51 citations

Cortical concentrations of corticotropin-releasing hormone and its receptor in Alzheimer type dementia and major depression

1990 • 44 citations

Reciprocal cross-desensitization of locus coeruleus electrophysiological responsivity to corticotropin-releasing factor and stress

1996 • 41 citations

Inhibitory effect of norepinephrine on immunoreactive corticotropin-releasing factor release from the rat hypothalamus in vitro

1987 • 37 citations

Quantitative distribution of monoamine oxidase A in brainstem monoamine nuclei is normal in major depression

1999 • 33 citations

Localization of corticotropin-releasing hormone in the human locus coeruleus and pedunculopontine tegmental nucleus: An immunocytochemical and in situ hybridization study

1995 • 29 citations

Pharmacodynamic and receptor binding changes during chronic lorazepam administration

2001 • 25 citations

Effects of sertraline on regional neuropeptide concentrations in olfactory bulbectomized rats

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A follow up study of suicide attempters: Increase of CSF–somatostatin but no change in CSF–CRH

2001 • 21 citations

Hypothalamic norepinephrine depletion inhibits CRF-41 release following neural stimuli

1993 • 10 citations