Diminished Anxiety- and Depression-Related Behaviors in Mice with Selective Deletion of theTac1Gene

Depression: a new animal model sensitive to antidepressant treatments

1977 • 4,272 citations

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

The tail suspension test: A new method for screening antidepressants in mice

1985 • 3,300 citations

Behavioral despair in mice: a primary screening test for antidepressants.

1977 • 3,241 citations

Assessing antidepressant activity in rodents: recent developments and future needs

2002 • 1,525 citations

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

1995 • 1,211 citations

Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

1998 • 1,067 citations

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988 • 1,053 citations

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

2002 • 901 citations

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

1998 • 757 citations

Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety

1994 • 702 citations

Primary afferent tachykinins are required to experience moderate to intense pain

1998 • 587 citations

Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice

2001 • 499 citations

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

1996 • 485 citations

In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist

1993 • 376 citations

Animal Models of Depression: Utility for Transgenic Research

2000 • 284 citations

Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function

2001 • 283 citations

Increased stress response and β–phenylethylamine in MAOB–deficient mice

1997 • 254 citations

Anatomical, Physiological, and Behavioral Aspects of Olfactory Bulbectomy in The Rat

1981 • 218 citations

The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.

2001 • 218 citations

Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene

1998 • 216 citations

Rewarding effects of opiates are absent in mice lacking the receptor for substance P

2000 • 215 citations

The automated tail suspension test: A computerized device which differentiates psychotropic drugs

1987 • 211 citations

Neuroanatomical localisation of Substance P in the CNS and sensory neurons

2000 • 184 citations

Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.

1992 • 175 citations

Pharmacological blockade or genetic deletion of substance P (NK1) receptors attenuates neonatal vocalisation in guinea-pigs and mice

2000 • 171 citations

Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice

1996 • 164 citations

Comparison of the phenotype of NK1R−/− mice with pharmacological blockade of the substance P (NK 1 ) receptor in assays for antidepressant and anxiolytic drugs

2001 • 151 citations

GR205171: A novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity

1996 • 146 citations

Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social Behaviour

1985 • 142 citations

Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice

2001 • 132 citations

Elevation of substance P-like peptides in the CSF of psychiatric patients.

1984 • 130 citations

Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat

1996 • 115 citations

Anxiolytic Action of a Neurokinin1 Receptor Antagonist in the Social Interaction Test

1997 • 112 citations

Identification of Multiple Genetic Loci Linked to the Propensity for “Behavioral Despair” in Mice

2002 • 110 citations

Colocalization of Peptide and Glucocorticoid Receptor Immunoreactivities in Rat Central Amygdaloid Nucleus

1992 • 106 citations

Individual differences in response to imipramine in the mouse tail suspension test

1997 • 90 citations

Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function

2001 • 88 citations

Brain Output Dysregulation Induced by Olfactory Bulbectomy: An Approximation in the Rat of Major Depressive Disorder in Humans?

1988 • 86 citations

Selective blockade of neurokinin-2 receptors produces antidepressant-like effects associated with reduced corticotropin-releasing factor function.

2001 • 85 citations

Anxiolytic actions of the substance P (NK1) receptor antagonist L-760735 and the 5-HT1A agonist 8-OH-DPAT in the social interaction test in gerbils

2001 • 79 citations

Acute and chronic effects of three benzodiazepines in the social interaction anxiety test in mice

1979 • 76 citations

Brain uptake and receptor binding of two [11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171 — PET studies in rhesus monkey

2000 • 74 citations

NKP608, an NK1 receptor antagonist, has an anxiolytic action in the social interaction test in rats

2000 • 73 citations

Behavioral reactivity to aversive stimuli in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: effects of diazepam and FG-7142

1997 • 60 citations

Effects of SR48968, a selective non-peptide NK 2 receptor antagonist on emotional processes in rodents

2001 • 55 citations

Changed Concentrations of Tachykinins and Neuropeptide Y in Brain of a Rat Model of Depression Lithium Treatment Normalizes Tachykinins

2001 • 52 citations

Dissociation of multiple behavioral effects between olfactory bulbectomized C57B1/6J and DBA/2J mice

1992 • 48 citations

Preprotachykinin-A mRNA expression in the human and monkey brain: An in situ hybridization study

1999 • 41 citations

Presence of NK₂ binding sites in the rat brain

2001 • 34 citations

Different behavioral profiles of the non-peptide substance P (NK1) antagonists CP-96,345 and RP 67580 in Swiss albino mice in the black-and-white box

1993 • 17 citations

Historical perspective on CMS model

1997 • 15 citations