Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice

The tail suspension test: A new method for screening antidepressants in mice

1985 • 3,300 citations

Behavioral despair in mice: a primary screening test for antidepressants.

1977 • 3,241 citations

Learned helplessness: Theory and evidence.

1976 • 2,255 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Assessing antidepressant activity in rodents: recent developments and future needs

2002 • 1,525 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Current advances and trends in the treatment of depression

1994 • 1,111 citations

Increased anxiety of mice lacking the serotonin _1A receptor

1998 • 684 citations

Gender Differences in Treatment Response to Sertraline Versus Imipramine in Chronic Depression

2000 • 679 citations

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

1995 • 659 citations

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

1995 • 649 citations

Research and treatment approaches to depression

2001 • 648 citations

Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice

2001 • 499 citations

Central Hypotensive Effects of the α _2a -Adrenergic Receptor Subtype

1996 • 484 citations

Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine

1997 • 480 citations

Cardiovascular Regulation in Mice Lacking α ₂ -Adrenergic Receptor Subtypes b and c

1996 • 463 citations

Specificity of the learned helplessness model of depression

1982 • 383 citations

Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice

1994 • 334 citations

cAMP Response Element-Binding Protein Is Essential for the Upregulation of Brain-Derived Neurotrophic Factor Transcription, But Not the Behavioral or Endocrine Responses to Antidepressant Drugs

2002 • 330 citations

Evaluation of Antidepressant-related Behavioral Responses in Mice Lacking the Serotonin Transporter

2002 • 287 citations

Learned helplessness and animal models of depression

1984 • 286 citations

Intra- and interstrain differences in models of “behavioral despair”

2001 • 247 citations

Gender differences in drug metabolism regulated by growth hormone

1995 • 227 citations

Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac)

2002 • 226 citations

The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.

2001 • 218 citations

The automated tail suspension test: A computerized device which differentiates psychotropic drugs

1987 • 211 citations

Gender and depression

1985 • 207 citations

Depression – emerging insights from neurobiology

2001 • 205 citations

Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice.

2001 • 199 citations

Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: Mouse strain-dependent outcomes.

2001 • 197 citations

Amitriptyline plasma levels and therapeutic response

1976 • 194 citations

A neuropharmacologically-relevant animal model of depression

1979 • 162 citations

Reversal of learned helplessness by imipramine.

1979 • 153 citations

Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice.

1995 • 145 citations

Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice

2001 • 132 citations

Use of dopamine-beta-hydroxylase-deficient mice to determine the role of norepinephrine in the mechanism of action of antidepressant drugs.

2001 • 130 citations

Stressor-provoked behavioral changes in six strains of mice.

1988 • 129 citations

Murine models of depression

1999 • 126 citations

Desmethylimipramine (DMI) counteracts learned helplessness in rats

1979 • 98 citations

Complications associated with genetic background effects in models of experimental epilepsy

2002 • 96 citations

Impact of chronic intermittent challenges in stressor-susceptible and resilient strains of mice

2003 • 72 citations

Gender Differences in Learned Helplessness Behavior Are Influenced by Genetic Background

2000 • 66 citations

Evidence for a Depressive-like State Induced by Repeated Saline Injections in Fischer 344 Rats

1997 • 65 citations

Effects of nortriptyline treatment on learned helplessness in the rat

1981 • 64 citations

Are there gender differences in the temperature profile of mice after acute antidepressant administration and exposure to two animal models of depression?

2001 • 60 citations

Strain-specific effects of antidepressants on escape deficits induced by inescapable shock

1989 • 60 citations

The Pharmacologic Treatment of Depression

2002 • 44 citations

Plasma levels, psychophysiological variables, and clinical response to amitriptyline

1982 • 27 citations

Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after one and six half-life repeated administrations to rats

1996 • 24 citations

Validation of a Therapeutic Plasma Level Range in Amitriptyline Treatment of Depression

1989 • 20 citations

Serum Levels of Amitriptyline andTherapeutic Effect in Non-Delusional Moderately to Severely DepressedIn-Patients: a Therapeutic WindowRelationship

2001 • 18 citations