Autoradiographic Demonstration of Increased Serotonin 5-HT2 and β-Adrenergic Receptor Binding Sites in the Brain of Suicide Victims

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

5-HIAA in the Cerebrospinal Fluid

1976 • 1,430 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior

1983 • 1,290 citations

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

1986 • 1,255 citations

Analysis of radioligand binding experiments

1985 • 1,247 citations

Serotonergic Studies in Patients With Affective and Personality Disorders

1989 • 1,093 citations

Aggression, suicide, and serotonin: relationships to CSF amine metabolites

1982 • 915 citations

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 • 840 citations

Development of β-adrenergic receptor subsensitivity by antidepressants

1977 • 727 citations

Suicide and Primary Affective Disorders

1970 • 722 citations

Effects of Age on Dopamine and Serotonin Receptors Measured by Positron Tomography in the Living Human Brain

1984 • 701 citations

Monoamine Metabolites in CSF and Suicidal Behavior

1981 • 692 citations

Serotonin receptors in the human brain—III. Autoradiographic mapping of serotonin-1 receptors

1987 • 569 citations

Increased Serotonin2 and β-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims

1986 • 552 citations

INCREASED SEROTONIN-2 BINDING SITES IN FRONTAL CORTEX OF SUICIDE VICTIMS

1983 • 527 citations

Mismatches between neurotransmitter and receptor localizations in brain: observations and implications

1987 • 524 citations

Subcortical projections from the temporal neocortex in Macaca mulatta

1956 • 502 citations

5-Hydroxytryptamine in the Hind-Brain of Depressive Suicides

1967 • 424 citations

Fibre Degeneration Following Lesions of the Amygdaloid Complex in the Monkey

1993 • 373 citations

Alcohol and Central Serotonin Metabolism in Man

1979 • 368 citations

5-Hydroxytryptamine Receptor Subtypes

1988 • 361 citations

Characteristics of central 5-HT receptors and their adaptive changes following intracerebral 5,7-dihydroxytryptamine administration in the rat.

1978 • 336 citations

The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific

1987 • 319 citations

NORADRENALINE, 5-HYDROXYTRYPTAMINE, AND 5-HYDROXYINDOLEACETIC ACID IN HINDBRAINS OF SUICIDAL PATIENTS

1968 • 304 citations

SEASONAL AND CIRCADIAN MONOAMINE VARIATIONS IN HUMAN BRAINS EXAMINED POST MORTEM

1980 • 303 citations

Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides

1984 • 301 citations

β ₁ - and β ₂ -Adrenergic Receptors in Rat Cerebral Cortex Are Independently Regulated

1979 • 296 citations

5-HYDROXYTRYPTAMINE, NORADRENALINE, AND DOPAMINE IN BRAINSTEM, HYPOTHALAMUS, AND CAUDATE NUCLEUS OF CONTROLS AND OF PATIENTS COMMITTING SUICIDE BY COAL-GAS POISONING

1969 • 259 citations

β-Adrenergic Receptor Involvement in 6-Hydroxydopamine-Induced Supersensitivity in Rat Cerebral Cortex

1976 • 238 citations

DETERMINATION OF MONOAMINE AND MONOAMINE METABOLITES IN THE HUMAN BRAIN: POST MORTEM STUDIES IN A GROUP OF SUICIDES AND IN A CONTROL GROUP

1976 • 224 citations

CSF 5-hydroxyindoleacetic acid levels in suicidal schizophrenic patients

1984 • 216 citations

Brain 5-HT2 receptor binding sites in depressed suicide victims

1988 • 215 citations

Symptom patterns in unipolar and bipolar depression correlating with monoamine metabolites in the cerebrospinal fluid: II. Suicide

1980 • 208 citations

Regulation of serotonin2 (5-HT2) receptors labeled with [3H]spiroperidol by chronic treatment with the antidepressant amitriptyline.

1980 • 207 citations

Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients.

1974 • 206 citations

Serotonin receptor sensitivity after acute and chronic treatment with mianserin.

1982 • 188 citations

Biochemical markers in suicidal patientsInvestigations with cerebrospinal fluid amine metabolites and neuroendocrine tests

1984 • 185 citations

Human brain receptor alterations in suicide victims

1982 • 179 citations

Effect of aging on neurotransmitter receptor binding in rat and human brain

1979 • 169 citations

Electroconvulsive shock treatment decreases β-adrenergic receptor sensitivity in rat brain

1979 • 167 citations

Serotonergic mechanisms in brains of suicide victims

1986 • 153 citations

Analysis of seasonal fluctuations of CSF monoamine metabolites and neuropeptides in normal controls: Findings with 5HIAA and HVA

1988 • 143 citations

Suicidal behavior, impulsiveness and serotonin

1988 • 137 citations

Circadian rhythms in mammalian neurotransmitter receptors

1987 • 136 citations

Retrograde degeneration of the thalamus following prefrontal lobotomy

1947 • 133 citations

Electrical stimulation of cerebellar fastigial nucleus increases cerebral cortical blood flow without change in local metabolism: Evidence for an intrinsic system in brain for primary vasodilation

1983 • 130 citations

Noradrenergic innervation of monkey prefrontal cortex: A dopamine‐β‐hydroxylase immunohistochemical study

1989 • 125 citations

Serotonin and 5-Hydroxyindoleacetic Acid in Brains of Suicide Victims

1986 • 122 citations

Different Synaptic Location of Mianserin and Imipramine Binding Sites

1982 • 120 citations

Alcoholism, hopelessness and suicidal behavior.

1976 • 115 citations

Autoradiographic Analysis of Tritiated Imipramine Binding in the Human Brain Post Mortem: Effects of Suicide

1989 • 114 citations

Regional serotonin levels in brain: a comparison of depressive suicides and alcoholic suicides with controls.

1976 • 99 citations

Cerebrospinal Fluid Correlates of Suicide Attempts and Aggression

1986 • 99 citations

Regionally selective increases in β-adrenergic receptor density in the brains of suicide victims

1988 • 96 citations

Life at risk: markers of suicidality in depression.

1983 • 89 citations

The role of free serum tryptophan in the biphasic effect of acute ethanol administration on the concentrations of rat brain tryptophan, 5-hydroxytryptamine and 5-hydroxyindol-3-ylacetic acid

1976 • 87 citations

RELATIONSHIP OF MATERNAL AND PERINATAL CONDITIONS TO EVENTUAL ADOLESCENT SUICIDE

1985 • 86 citations

Extracortical connections of the primate frontal cerebral cortex I. Thalamo‐cortical connections

1947 • 84 citations

Monoamine oxidase inhibitors and serotonin uptake inhibitors: differential effects on [3H]serotonin binding sites in rat brain.

1980 • 82 citations

Suicide in Schizophrenia

1986 • 76 citations

In vivo regulation of the serotonin-2 receptor in rat brain

1986 • 75 citations

Relationships of Precentral, Premotor and Prefrontal Cortex to the Mediodorsal and Intralaminar Nuclei of the Monkey Thalamus

1980 • 74 citations

Postmortem Neurochemical Studies in Depression

1986 • 72 citations

Extracortical connections of the primate frontal cerebral cortex II. CORTICIFUGAL CONNECTIONS

1947 • 69 citations

Characterization of Two [³H]Ketanserin Recognition Sites in Rat Striatum

1987 • 67 citations

Genetics of Suicide

1986 • 63 citations

Serotonergic split brain and suicide

1987 • 61 citations

Characterization and localization of serotonin receptors in human brain postmortem

1986 • 61 citations

Comparison of two putatively selective radioligands for labeling central nervous system beta-adrenergic receptors: inadequacy of [3H]dihydroalprenolol.

1989 • 56 citations

Comparison of [¹²⁵I]Iodolysergic Acid Diethylamide Binding in Human Frontal Cortex and Platelet Tissue

1989 • 56 citations

Indices of Serotonin and Glucose Metabolism in Violent Offenders, Arsonists, and Alcoholics

1986 • 55 citations

An inexpensive microcomputer digital imaging system for densitometry: quantitative autoradiography of insulin receptors with 125I and LKB ultrofilm

1986 • 52 citations

Serotonergic Function and Suicidal Behavior in Personality Disordersa

1986 • 48 citations

Serotonin concentrations in normal aging human brains: Relation to serotonin receptors

1984 • 46 citations

Autoradiographic Analysis of [³H]Imipramine Binding in the Human Brain Postmortem: Effects of Age and Alcohol

1988 • 45 citations

Suicide and Substance Abuse

1988 • 44 citations

Autoradiographic analysis of [3H]desmethylimipramine binding in the human brain postmortem

1988 • 44 citations

Statistical Approaches to Suicidal Risk Factor Analysis

1986 • 43 citations

Psychobiologic predictors of suicide.

1987 • 41 citations

A high density of muscarinic receptors in the rostral ventrolateral medulla of the rat is revealed by correction for autoradiographic efficiency

1988 • 41 citations

The serotonin/norepinephrine-link in brain. II. Role of serotonin in the regulation of beta adrenoceptors in the low agonist affinity conformation.

1988 • 37 citations

Localization and characterization by quantitative autoradiography of [125I]LSD binding sites in rat brain

1984 • 36 citations

EFFECTS OF AGE ON DOPAMINE AND SEROTONIN RECEPTORS MEASURED BY POSITRON TOMOGRAPHY IN THE LIVING HUMAN BRAIN

1985 • 35 citations

High affinity [3H]desipramine binding in rat cerebral cortex decreases after selective lesion of noradrenergic neurons with 6-hydroxydopamine

1981 • 30 citations

High affinity non-β-adrenoceptor binding of β-adrenergic ligands

1985 • 26 citations

125I-LSD autoradiography confirms the preferential localization of caudate-putamen S2 receptors to the caudal (peripallidal) region

1986 • 26 citations

Postmortem Monoamine Receptor and Enzyme Studies in Suicidea

1986 • 24 citations

Demonstration of high- and low-affinity β-adrenergic receptors in slide-mounted sections of rat and human brain

1990 • 23 citations

Quantitative distribution of muscarinic receptors and choline acetyltransferase in rat medulla: examination of transmitter-receptor mismatch

1988 • 23 citations

[3H]Ketanserin Labels Serotonin 5-HT2 and α1-Adrenergic Receptors in Human Brain Cortex

1987 • 20 citations

Aminergic receptor binding correlates of suicide: methodological issues.

1986 • 3 citations

CNS adrenergic receptors and beta blockade.

1988 • 2 citations