Behavioral characterization of dopamine D₅ receptor null mutant mice.

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Depression: a new animal model sensitive to antidepressant treatments

1977 • 4,272 citations

Dopamine Receptors: From Structure to Function

1998 • 3,489 citations

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

1992 • 2,910 citations

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

1992 • 2,621 citations

A framework for mesencephalic dopamine systems based on predictive Hebbian learning

1996 • 2,003 citations

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

1995 • 1,600 citations

Society for Neuroscience Abstracts

1997 • 1,445 citations

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

1997 • 1,362 citations

Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task

1993 • 1,279 citations

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

1991 • 1,157 citations

Gating and Habituation of the Startle Reflex in Schizophrenic Patients

1992 • 1,030 citations

Dopamine receptor pharmacology

1994 • 959 citations

What's Wrong with My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice

2000 • 934 citations

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

1996 • 895 citations

Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions

1993 • 877 citations

Serotonin receptor 1A knockout: An animal model of anxiety-related disorder

1998 • 802 citations

Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system processes sensory input.

1980 • 783 citations

Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats

1997 • 762 citations

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests1Published on the World Wide Web on 2 December 1998.1

1999 • 751 citations

Elevated anxiety and antidepressant-like responses in serotonin 5-HT _1A receptor mutant mice

1998 • 690 citations

Dopaminergic stimulation disrupts sensorimotor gating in the rat

1988 • 609 citations

Using an Animal Model of Deficient Sensorimotor Gating to Study the Pathophysiology and New Treatments of Schizophrenia

1998 • 608 citations

Dopamine receptors and brain function

1996 • 564 citations

The mesolimbic dopamine system : from motivation to action

1991 • 555 citations

A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

1997 • 553 citations

Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

1981 • 509 citations

Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice

2001 • 499 citations

Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses

1994 • 490 citations

Dopamine receptors: Molecular biology, biochemistry and behavioural aspects

1994 • 489 citations

Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain

1995 • 486 citations

Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal ltp in the range of the θ frequency

1995 • 464 citations

Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations

1998 • 448 citations

Direct protein–protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors

2000 • 437 citations

Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli

1999 • 435 citations

Advances in pharmacology

1962 • 412 citations

The Cortical Dopamine System: Role in Memory and Cognition

1997 • 396 citations

Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists.

1991 • 396 citations

Inbred strain differences in prepulse inhibition of the mouse startle response

1997 • 385 citations

Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test

1999 • 379 citations

D1/D5 Dopamine Receptor Activation Increases the Magnitude of Early Long-Term Potentiation at CA1 Hippocampal Synapses

1996 • 374 citations

The hippocampal formation is necessary for rats to learn and remember configural discriminations

1989 • 374 citations

Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.

1991 • 359 citations

Altered striatal function in a mutant mouse lacking D1A dopamine receptors.

1994 • 350 citations

Functions of dopamine in the dorsal and ventral striatum

1992 • 340 citations

Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth

1995 • 336 citations

Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice

1994 • 334 citations

Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists.

1991 • 330 citations

Dissociating context and space within the hippocampus: Effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning.

1999 • 328 citations

Behavioural assessment of mice lacking D1A dopamine receptors

1998 • 325 citations

α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of Acra7-Deficient Mice

1998 • 295 citations

Animal Models of Depression: Utility for Transgenic Research

2000 • 284 citations

Distribution of D2 dopamine receptor mRNA in rat brain.

1989 • 263 citations

Molecular Neurobiology of Dopaminergic Receptors

1993 • 251 citations

Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine

1990 • 233 citations

Dopamine and Spatial Working Memory in Rats and Monkeys: Pharmacological Reversal of Stress-Induced Impairment

1996 • 228 citations

NEW INSIGHTS INTO DOPAMINERGIC RECEPTOR FUNCTION USING ANTISENSE AND GENETICALLY ALTERED ANIMALS

1999 • 220 citations

Assessment of locomotor activity, acoustic and tactile startle, and prepulse inhibition of startle in inbred mouse strains and F1 hybrids: Implications of genetic background for single gene and quantitative trait loci analyses

1997 • 216 citations

Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.

1991 • 210 citations

Dopamine D5 receptor immunolocalization in rat and monkey brain

2000 • 207 citations

Targeted gene mutation approaches to the study of anxiety-like behavior in mice

2001 • 203 citations

Spatial learning deficit in dopamine D1 receptor knockout mice

1999 • 183 citations

Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease

2001 • 179 citations

The Dopamine D₂, but not D₃or D₄, Receptor Subtype is Essential for the Disruption of Prepulse Inhibition Produced by Amphetamine in Mice

1999 • 179 citations

Responses of Swiss–Webster Mice to Repeated Plus-Maze Experience Further Evidence for a Qualitative Shift in Emotional State?

1998 • 177 citations

Distribution of D5 dopamine receptor mRNA in rat brain

1992 • 176 citations

A double dissociation within the hippocampus of dopamine D1/D5 receptor and β-adrenergic receptor contributions to the persistence of long-term potentiation

1999 • 174 citations

D1/D5 Dopamine Receptors Inhibit Depotentiation at CA1 Synapses via cAMP-Dependent Mechanism

1998 • 167 citations

Beyond the Dopamine Hypothesis

1989 • 155 citations

Mice, gene targeting and behaviour: more than just genetic background

1996 • 150 citations

D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatum

1996 • 147 citations

Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor

2000 • 145 citations

Behavioural performance in three substrains of mouse strain 129

1997 • 144 citations

Contextual learning and cue association in fear conditioning in mice: a strain comparison and a lesion study

1998 • 142 citations

A D2 dopamine receptor agonist disrupts sensorimotor gating in rats. Implications for dopaminergic abnormalities in schizophrenia.

1990 • 138 citations

Pharmacologic and Behavioral Responses of Inbred C57BL/6J and Strain 129/SvJ Mouse Lines

1999 • 136 citations

Differential effects of the N-methyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues.

1994 • 135 citations

Dopamine receptor distribution in the rat CNS: elucidation using anti-peptide antisera directed against D1A and D3 subtypes

1994 • 135 citations

Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice

1998 • 134 citations

Dopamine receptor pharmacology.

1993 • 133 citations

Ethopharmacology of imipramine in the forced-swimming test: gender differences

1998 • 131 citations

Is the hippocampus necessary for contextual fear conditioning?

2000 • 130 citations

Effects of maternal stress during pregnancy on forced swimming test behavior of the offspring

1991 • 125 citations

Opposite responses of mesolimbic dopamine system to controllable and uncontrollable aversive experiences

1994 • 124 citations

Differential effects of the N-methyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues.

1994 • 112 citations

Intra-accumbens infusion of quinpirole impairs sensorimotor gating of acoustic startle in rats

1993 • 112 citations

The mesolimbic dopamine system: From motivation to action

1992 • 111 citations

Dopamine Receptors and Dopamine Transporter in Brain Function and Addictive Behaviors: Insights from Targeted Mouse Mutants

1998 • 105 citations

Current opinion in neurology and neurosurgery

1989 • 101 citations

Dopamine and the pharmacology of schizophrenia: The state of the evidence

1974 • 99 citations

Dopamine D3 receptor mutant and wild-type mice exhibit identical responses to putative D3 receptor-selective agonists and antagonists

1999 • 97 citations

Effects of strain and serotonergic agents on prepulse inhibition and habituation in mice

2000 • 97 citations

Dopaminergic Regulation of Progesterone Receptors: Brain D5 Dopamine Receptors Mediate Induction of Lordosis by D1-Like Agonists in Rats

1996 • 93 citations

Genetic analysis of anxiety-related behaviors and responses to benzodiazepine-related drugs in AXB and BXA recombinant inbred mouse strains

1995 • 91 citations

Molecular, Cellular, and Neuroanatomical Substrates of Place Learning

1998 • 90 citations

Dopamine D-5 receptor modulates hippocampal acetylcholine release

2000 • 89 citations

Action sequencing is impaired in D_1A‐deficient mutant mice

1998 • 85 citations

Topographical evaluation of the phenotype of spontaneous behaviour in mice with targeted gene deletion of the D1A dopamine receptor: paradoxical elevation of grooming syntax

1998 • 78 citations

Do ? Interactions Regulate Prepulse Inhibition in Rats?

1996 • 78 citations

Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D1A-deficient mouse

1997 • 76 citations

D1 and D2 dopamine receptor antagonists reverse prepulse inhibition deficits in an animal model of schizophrenia

1994 • 70 citations

Opposite roles of D1 and D5 dopamine receptors in locomotion revealed by selective antisense oligonucleotides

1998 • 69 citations

Distribution of dopamine D1, D2, and D5 receptor mRNAs in the monkey brain: ribonuclease protection assay analysis

1995 • 69 citations

Dopaminergic modulation of LTP induction in the dentate gyrus of intact brain

1997 • 66 citations

Conservation of behavioural topography to dopamine D1-like receptor agonists in mutant mice lacking the D1A receptor implicates a D1-like receptor not coupled to adenylyl cyclase

1999 • 64 citations

Effects of “Binge” Pattern Cocaine on Stereotypy and Locomotor Activity in C57BL/6J and 129/J Mice

1998 • 61 citations

Immunoblot and immunohistochemical comparison of murine monoclonal antibodies specific for the rat D1a and D1b dopamine receptor subtypes

1999 • 57 citations

Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor

2000 • 56 citations

The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease

1995 • 56 citations

Behavioral effects of cocaine: interactions with D1 dopaminergic antagonists and agonists in mice and squirrel monkeys.

1999 • 44 citations

Heterogeneous tissue-specific transcription of dopamine receptor subtype messenger RNA in rat brain

1994 • 43 citations

Paradoxical Locomotor Behavior of Dopamine D1 Receptor Transgenic Mice

1999 • 33 citations

An early lesion of the lateral septal nuclei produces changes in the forced swim test depending on gender

1995 • 30 citations

Association between schizophrenia and a microsatellite polymorphism at the dopamine D5 receptor gene

1997 • 20 citations

Effects of acute social defeat on activity in the forced swim test: Parametric studies in DBA/2 mice using a novel measurement device

1998 • 18 citations

Linkage study of the D5 dopamine receptor gene (DRD5) in multiplex Icelandic and English schizophrenia pedigrees

1996 • 16 citations

Linkage analysis between schizophrenia and a microsatellite polymorphism for the D5 dopamine receptor gene

1994 • 14 citations