The mouse: genetics meets behaviour

Emotion Circuits in the Brain

2000 • 8,055 citations

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

1998 • 3,711 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

Synaptic Plasticity and Memory: An Evaluation of the Hypothesis

2000 • 2,700 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

2000 • 2,065 citations

Reduced Number of Hypocretin Neurons in Human Narcolepsy

2000 • 2,004 citations

Molecular basis of long-term plasticity underlying addiction

2001 • 1,831 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

1996 • 1,750 citations

Genetics of Mouse Behavior: Interactions with Laboratory Environment

1999 • 1,626 citations

Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

1994 • 1,570 citations

Control of Memory Formation Through Regulated Expression of a CaMKII Transgene

1996 • 1,525 citations

Molecular Analysis of Mammalian Circadian Rhythms

2001 • 1,428 citations

An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

2001 • 1,421 citations

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,336 citations

Molecular and Cellular Basis of Addiction

1997 • 1,324 citations

The neurobiology of startle

1999 • 1,239 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease

2000 • 1,063 citations

Autophosphorylation at Thr ²⁸⁶ of the α Calcium-Calmodulin Kinase II in LTP and Learning

1998 • 1,045 citations

Dopamine responses comply with basic assumptions of formal learning theory

2001 • 1,034 citations

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

2001 • 876 citations

Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

1999 • 825 citations

Essential Role for TrkB Receptors in Hippocampus-Mediated Learning

1999 • 797 citations

Conditional control of gene expression in the mouse

2001 • 774 citations

Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1

1999 • 756 citations

To Eat or to Sleep? Orexin in the Regulation of Feeding and Wakefulness

2001 • 754 citations

Recombineering: a powerful new tool for mouse functional genomics

2001 • 743 citations

A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

2000 • 733 citations

Molecular mechanisms of memory acquisition, consolidation and retrieval

2001 • 696 citations

The mPer2 gene encodes a functional component of the mammalian circadian clock

1999 • 692 citations

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

2000 • 661 citations

Identification of genes that modify ataxin-1-induced neurodegeneration

2000 • 659 citations

Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

1999 • 630 citations

Using an Animal Model of Deficient Sensorimotor Gating to Study the Pathophysiology and New Treatments of Schizophrenia

1998 • 608 citations

Distinct components of spatial learning revealed by prior training and NMDA receptor blockade

1995 • 560 citations

Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans

1999 • 558 citations

A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

1997 • 553 citations

Molecular Genetics of Circadian Rhythms in Mammals

2000 • 541 citations

A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock

2001 • 508 citations

Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training

1997 • 484 citations

Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

1997 • 481 citations

Learning Deficit in BDNF Mutant Mice

1997 • 470 citations

Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin

2001 • 464 citations

Drosophila: Genetics meets behaviour

2001 • 454 citations

The hypocretin/orexin ligand–receptor system: implications for sleep and sleep disorders

2000 • 451 citations

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

1998 • 445 citations

Long-Term Memory Is Facilitated by cAMP Response Element-Binding Protein Overexpression in the Amygdala

2001 • 441 citations

Ethanol Intoxication in Drosophila: Genetic and Pharmacological Evidence for Regulation by the cAMP Signaling Pathway

1998 • 439 citations

Cycling vrille Expression Is Required for a Functional Drosophila Clock

1999 • 433 citations

Functional analysis of secreted and transmembrane proteins critical to mouse development

2001 • 404 citations

Defining brain wiring patterns and mechanisms through gene trapping in mice

2001 • 391 citations

Genomic strategies to identify mammalian regulatory sequences

2001 • 389 citations

Gene-trap mutagenesis: past, present and beyond

2001 • 389 citations

Spaced training induces normal long-term memory in CREB mutant mice

1997 • 357 citations

GENE DISCOVERY INDROSOPHILA: New Insights for Learning and Memory

1998 • 344 citations

Psychiatric genetics: search for phenotypes

1998 • 334 citations

Positive and negative regulatory mechanisms that mediate long-term memory storage

1998 • 270 citations

Genetic approaches to memory storage

1999 • 262 citations

Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice

2001 • 244 citations

[Monogenic causes of X-linked mental retardation].

2006 • 227 citations

A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis

2001 • 224 citations

The flexible genome

2001 • 217 citations

Deficits in Memory Tasks of Mice with CREB Mutations Depend on Gene Dosage

1998 • 214 citations

The Notch ligand Jagged1 is required for inner ear sensory development

2001 • 210 citations

Molecular Components of the Circadian System in Drosophila

2001 • 210 citations

The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs

2000 • 208 citations

Are Complex Behaviors Specified by Dedicated Regulatory Genes? Reasoning from Drosophila

2001 • 203 citations

The Dopamine D₂, but not D₃or D₄, Receptor Subtype is Essential for the Disruption of Prepulse Inhibition Produced by Amphetamine in Mice

1999 • 179 citations

Behavioral characterization of dopamine D₅ receptor null mutant mice.

2001 • 176 citations

QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice

2001 • 169 citations

Quantitative trait locus analysis of contextual fear conditioning in mice

1997 • 169 citations

Impaired Maternal Behavior in Mice Lacking Norepinephrine and Epinephrine

1997 • 169 citations

Behavior and mutagenesis screens: the importance of baseline analysis of inbred strains

2000 • 158 citations

The cAMP–Protein Kinase A Signal Transduction Pathway Modulates Ethanol Consumption and Sedative Effects of Ethanol

2001 • 152 citations

Quantitative trait loci analysis affecting contextual conditioning in mice

1997 • 150 citations

Alternative phenotypes for the complex genetics of schizophrenia

1999 • 150 citations

Hypocretin/orexin, sleep and narcolepsy

2001 • 149 citations

Identification and Functional Analysis of Mutations in the Hypocretin (Orexin) Genes of Narcoleptic Canines

2001 • 149 citations

The Drosophila dCREB2 Gene Affects the Circadian Clock

1999 • 141 citations

Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells

2000 • 141 citations

The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti

2001 • 132 citations

Dissection of behavior and psychiatric disorders using the mouse as a model

2000 • 123 citations

Tetracycline-regulated gene expression in the brain

2000 • 116 citations

An Automated System for Recording and Analysis of Sleep in Mice

2000 • 115 citations

Behavioral analysis of CREB αΔ mutation on a B6/129 F1 hybrid background

2002 • 111 citations

Clinical methods in psychiatric genetics: I. Robustness of genetic marker investigative strategies

1986 • 110 citations

Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource

2000 • 110 citations

Genes, models and Alzheimer's disease

2001 • 108 citations

Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer

2000 • 107 citations

Capitalizing on large-scale mouse mutagenesis screens

2000 • 102 citations

Quantitative Trait Locus Mapping in Laboratory Mice Derived From a Replicated Selection Experiment for Open-Field Activity

2001 • 89 citations

ΔFosB: a molecular switch underlying long-term neural plasticity

2000 • 87 citations

High-Throughput Detection of Unknown Mutations by Using Multiplexed Capillary Electrophoresis with Poly(vinylpyrrolidone) Solution

2000 • 76 citations

double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs

1999 • 76 citations

List of transgenic and knockout mice: behavioral profiles

2000 • 73 citations

5‐HT Receptor Knockout Mice: Pharmacological Tools or Models of Psychiatric Disorders

1999 • 64 citations

Reassessment of the effect of biological rhythm mutations on learning in Drosophila melanogaster

1991 • 56 citations

Steroid receptor fusion proteins for conditional activation of raf-MEK-ERK signaling pathway

2001 • 44 citations

A genetic screen for novel behavioral mutations in mice

2000 • 39 citations

Trans-NIH neuroscience initiatives on mouse phenotyping and mutagenesis

2001 • 35 citations

On a wing and a prayer

2002 • 24 citations