Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

1995 • 2,090 citations

Physiology of the Neurotrophins

1996 • 1,908 citations

The validity of animal models of depression

1984 • 1,365 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

1996 • 1,200 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Antidepressant-Like Effect of Brain-derived Neurotrophic Factor (BDNF)

1997 • 829 citations

Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

1999 • 825 citations

BDNF regulates eating behavior and locomotor activity in mice

2000 • 788 citations

Neural plasticity to stress and antidepressant treatment

1999 • 638 citations

Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors.

1995 • 612 citations

“Behavioural despair” in rats and mice: Strain differences and the effects of imipramine

1978 • 604 citations

Neurotrophins and depression

1999 • 538 citations

Learning Deficit in BDNF Mutant Mice

1997 • 470 citations

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

1995 • 470 citations

5-HT_2AReceptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex

1997 • 448 citations

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

1995 • 413 citations

Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex

1999 • 306 citations

Role of norepinephrine in the pathophysiology and treatment of mood disorders

1999 • 291 citations

Open field, learned helplessness, conditioned defensive burying, and forced-swim tests in WKY rats

1994 • 260 citations

Absence of Sensory Neurons before Target Innervation in Brain-Derived Neurotrophic Factor-, Neurotrophin 3-, and TrkC-Deficient Embryonic Mice

1997 • 217 citations

A role for BDNF in mechanosensation

1998 • 194 citations

The staircase test in mice: A simple and efficient procedure for primary screening of anxiolytic agents

1984 • 192 citations

Characterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia

1998 • 189 citations

Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3

1994 • 165 citations

Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC

1999 • 157 citations

Depressive behavior and stress ulcer in Wistar Kyoto rats

1993 • 146 citations

Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice.

1995 • 145 citations

Disturbed emotionality in autoimmune MRL-lpr mice

1994 • 138 citations

Stressor-provoked behavioral changes in six strains of mice.

1988 • 129 citations

Overexpression of Brain-Derived Neurotrophic Factor Enhances Sensory Innervation and Selectively Increases Neuron Number

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A behavioral profile of autoimmune lupus-prone MRL mice

1992 • 108 citations

Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities

2000 • 100 citations

Intact spatial learning and memory in transgenic mice with reduced BDNF

1997 • 96 citations

Behavior of streptozotocin-diabetic mice in tests of exploration, locomotion, anxiety, depression and aggression

1990 • 94 citations

BDNF Produces Analgesia in the Formalin Test and Modifies Neuropeptide Levels in Rat Brain and Spinal Cord Areas Associated With Nociception

1995 • 89 citations

Binding of Neurotrophin-3 to p75LNGFR, TrkA, and TrkB Mediated by a Single Functional Epitope Distinct from That Recognized by TrkC

1996 • 70 citations

Inositol reduces depressive-like behaviors in two different animal models of depression

1999 • 61 citations

Intracerebroventricular administration of brain-derived neurotrophic factor in adult rats affects analgesia and spontaneous behaviour but not memory retention in a Morris Water Maze task

2000 • 56 citations

Specific neurotrophin binding to leucine‐rich motif peptides of TrkA and TrkB

1995 • 34 citations

Stress-induced changes of norepinephrine uptake sites in the locus coeruleus of C57BL/6J and DBA/2J mice: a quantitative autoradiographic study using [3H]-tomoxetine

1999 • 25 citations