Preclinical models: status of basic research in depression

Emotion Circuits in the Brain

2000 • 8,055 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Neurobiology of Depression

2002 • 3,057 citations

The amygdala: vigilance and emotion

2000 • 2,823 citations

Maternal Care, Gene Expression, and the Transmission of Individual Differences in Stress Reactivity Across Generations

2001 • 2,665 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

The neurobiology of stress: from serendipity to clinical relevance11Published on the World Wide Web on 22 November 2000.

2000 • 1,784 citations

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

1997 • 1,773 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

The validity of animal models of depression

1984 • 1,365 citations

Cre recombinase: The universal reagent for genome tailoring

2000 • 1,197 citations

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

1988 • 1,180 citations

The cellular neurobiology of depression

2001 • 1,169 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

1998 • 1,067 citations

Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease

2000 • 1,063 citations

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988 • 1,053 citations

Neuroscience of Addiction

1998 • 1,030 citations

Molecular and Neuronal Substrate for the Selective Attenuation of Anxiety

2000 • 927 citations

Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity

2000 • 911 citations

Ligand-activated site-specific recombination in mice.

1996 • 885 citations

Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells

2000 • 810 citations

The forced swimming test as a model for core and component behavioral effects of antidepressant drugs

1997 • 788 citations

Neurobiological Similarities in Depression and Drug Dependence: A Self-Medication Hypothesis

1998 • 752 citations

Associative Processes in Addiction and Reward The Role of Amygdala‐Ventral Striatal Subsystems

1999 • 713 citations

Long-term behavioral and neuroendocrine adaptations to adverse early experience

2000 • 707 citations

The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death

2000 • 690 citations

Drug-activation of brain reward pathways

1998 • 679 citations

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

2000 • 661 citations

Neuronal plasticity and survival in mood disorders

2000 • 658 citations

The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety

1999 • 656 citations

Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.

1996 • 653 citations

Research and treatment approaches to depression

2001 • 648 citations

Neural plasticity to stress and antidepressant treatment

1999 • 638 citations

Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

1999 • 630 citations

Gene targeting: a practical approach.

1993 • 585 citations

Animal models of social stress: effects on behavior and brain neurochemical systems

2001 • 573 citations

Variations in maternal care in infancy regulate the development of stress reactivity

2000 • 572 citations

Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsome

1997 • 551 citations

The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions.

1996 • 547 citations

Neurotrophins and depression

1999 • 538 citations

Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.

1979 • 526 citations

Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior

1994 • 462 citations

The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3

2000 • 434 citations

Mouse ENU Mutagenesis

1999 • 414 citations

Neural and behavioral substrates of mood and mood regulation

2002 • 414 citations

Corticotrophin-releasing factor receptors: from molecular biology to drug design

1996 • 399 citations

Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2’s neurotrophic effects?

2000 • 398 citations

Anti-bipolar therapy: mechanism of action of lithium

1999 • 372 citations

Sleep Deprivation in the Rat

1966 • 356 citations

Psychiatric genetics: search for phenotypes

1998 • 334 citations

The Mood Stabilizer Valproic Acid Activates Mitogen-activated Protein Kinases and Promotes Neurite Growth

2001 • 332 citations

Neuroplasticity and cellular resilience in mood disorders

2000 • 332 citations

Psychosocial intervention development for the prevention and treatment of depression: promoting innovation and increasing access

2002 • 331 citations

Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics.

2001 • 328 citations

Corticotropin-releasing factor and neuropeptide y: role in emotional integration

1994 • 320 citations

Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis

2000 • 307 citations

Animal Models of Depression: Utility for Transgenic Research

2000 • 284 citations

Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function

2001 • 283 citations

Implications of failing to achieve successful long-term maintenance treatment of recurrent unipolar major depression

1998 • 280 citations

Quantitative Trait Loci Involved in Genetic Predisposition to Acute Alcohol Withdrawal in Mice

1997 • 275 citations

Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice

2001 • 264 citations

Identifying genes for alcohol and drug sensitivity: recent progress and future directions

1999 • 259 citations

Inducible and Reversible Gene Expression with the rtTA System for the Study of Memory

1998 • 254 citations

Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness

1999 • 247 citations

Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice

2001 • 244 citations

Forward and Reverse Genetic Approaches to Behavior in the Mouse

1994 • 243 citations

Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.

1994 • 241 citations

Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia.

1985 • 239 citations

Borna disease virus genome transcribed and expressed in psychiatric patients

1995 • 228 citations

In vivo neurogenesis in the adult brain: regulation and functional implications

2000 • 212 citations

Inducible site-specific recombination in the brain 1 1Edited by M. Yaniv

1999 • 203 citations

Respiration and Parturition Affected by Conditional Overexpression of the Ca ²⁺ -Activated K ⁺ Channel Subunit, SK3

2000 • 182 citations

QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice

2001 • 169 citations

Quantitative trait locus analysis of contextual fear conditioning in mice

1997 • 169 citations

Pharmacology of rapid-onset antidepressant treatment strategies.

2001 • 165 citations

Sleep deprivation in the rat: an animal model of mania

1995 • 164 citations

Quantitative trait loci analysis affecting contextual conditioning in mice

1997 • 150 citations

Alternative phenotypes for the complex genetics of schizophrenia

1999 • 150 citations

The American Psychiatric Press Textbook of Psychopharmacology

1995 • 142 citations

Neuropeptide Y effector systems: perspectives for drug development

1994 • 138 citations

The molecular foundations of psychiatry

1993 • 134 citations

Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies

2000 • 133 citations

Confirmation of Quantitative Trait Loci for Alcohol Preference in Mice

1998 • 129 citations

The N-methyl-d-aspartate receptor, synaptic plasticity, and depressive disorder

2000 • 128 citations

Future of genetics of mood disorders research

2002 • 128 citations

Antidepressant treatments in the 21st century

1998 • 124 citations

Dissection of behavior and psychiatric disorders using the mouse as a model

2000 • 123 citations

The Role of Early Environmental Events in Regulating Neuroendocrine Development: Moms, Pups, Stress, and Glucocorticoid Receptors

1996 • 119 citations

Chemical mutagenesis and fine-structure functional analysis of the mouse genome

1991 • 110 citations

Psychopharmacology of conditioned reward: evidence for a rewarding signal at D 1 -like dopamine receptors

1999 • 97 citations

Early environmental programming hypothalamic-pituitary-adrenal responses to stress

1994 • 97 citations

Functional Genomics in the Mouse: Phenotype-Based Mutagenesis Screens

1998 • 97 citations

Contemporary Issues in Modeling Psychopathology

2000 • 92 citations

The American Psychiatric Press Textbook of Psychopharmacology

1998 • 90 citations

Quantitative Trait Locus Mapping in Laboratory Mice Derived From a Replicated Selection Experiment for Open-Field Activity

2001 • 89 citations

Developing novel treatments for mood disorders: accelerating discovery

2002 • 81 citations

Toxin-induced conditioned changes in taste reactivity and the role of the chemosensitive area postrema

1995 • 80 citations

Diverse signalling by 5-hydroxytryptamine (5-HT) receptors

2000 • 80 citations

Genetic and pharmacological models of cholinergic supersensitivity and affective disorders

1988 • 78 citations

The Molecular Foundations of Psychiatry

1994 • 77 citations

Neuropsychiatric Toxicity of Antiviral Treatment in Chronic Hepatitis C

2000 • 76 citations

Splitting schizophrenia

1988 • 76 citations

Lithium Activates the c‐Jun NH₂‐Terminal Kinases In Vitro and in the CNS In Vivo

1999 • 69 citations

Overview of the past contributions of animal models and their changing place in psychiatry

2001 • 69 citations

Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse Chromosomes 1, 4, and 11

1999 • 67 citations

Effects of Antidepressant Drugs on Rats Bred for Low Activity in the Swim Test

1998 • 66 citations

Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic

2000 • 61 citations

Animal models of psychiatric disorders and their relevance to alcoholism.

2000 • 55 citations

Stress, Learned Helplessness, and Brain Interleukin-1β

1999 • 42 citations

Social rehabilitation of separation-induced depressive disorders in monkeys

1976 • 40 citations

Corticotropin-releasing factor antagonists in affective disorders

1999 • 35 citations

The GABA(A) receptor complex as a target for fluoxetine action.

1999 • 32 citations

Functional genomics in the mouse

2002 • 30 citations

Production of Corticotropin‐releasing Hormone‐deficient Mice by Targeted Mutation in Embryonic Stem Cells

1996 • 30 citations

Comparison of Rats Selectively Bred for High and Low Ethanol Intake in a Forced-Swim-Test Model of Depression

1997 • 28 citations

Animal Models of Bipolar Disorder: From a Single Episode to Progressive Cycling Models

2000 • 22 citations

Anxiety, depression, and mania

1991 • 15 citations

Anxiety, depression and mania: Animal models of psychiatric disorders

1992 • 13 citations

Neurotoxicity Related to the Use of Topical Tretinoin (Retin-A)

1996 • 10 citations

Mouse models of madness

1999 • 4 citations

Mouse genomics and informatics offer new tools for psychiatry

1999 • 3 citations