Blockade of nociceptin/orphanin FQ–NOP receptor signalling produces antidepressant‐like effects: pharmacological and genetic evidences from the mouse forced swimming test

Behavioral despair in mice: a primary screening test for antidepressants.

1977 • 3,241 citations

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1995 • 1,887 citations

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

1995 • 1,800 citations

Assessing antidepressant activity in rodents: recent developments and future needs

2002 • 1,525 citations

The forced swimming test as a model for core and component behavioral effects of antidepressant drugs

1997 • 788 citations

Pharmacology of nociceptin and its receptor: a novel therapeutic target

2000 • 426 citations

Intracerebroventricular injections in mice

1986 • 388 citations

Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor

1997 • 255 citations

Increase by the ORL₁ receptor (opioid receptor‐like₁) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones

1996 • 231 citations

Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro

1996 • 223 citations

Address and Message Sequences for the Nociceptin Receptor: A Structure−Activity Study of Nociceptin-(1−13)-peptide amide

1997 • 215 citations

Characterization of [Nphe¹]nociceptin(1‐13)NH₂, a new selective nociceptin receptor antagonist

2000 • 188 citations

Opioid receptor genes inactivated in mice: the highlights

2002 • 172 citations

In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist

2000 • 167 citations

[Nphe¹,Arg¹⁴,Lys¹⁵]Nociceptin‐NH₂, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor

2002 • 164 citations

Nociceptin/orphanin FQ and neurotransmitter release in the central nervous system

2000 • 117 citations

Nociceptin inhibits noradrenaline release in the mouse brain cortex via presynaptic ORL1 receptors

1998 • 81 citations

Nociceptin receptor antagonists display antidepressant-like properties in the mouse forced swimming test

2002 • 80 citations

Modulation of 5‐hydroxytryptamine efflux from rat cortical synaptosomes by opioids and nociceptin

2000 • 72 citations

Inhibitory effect of nociceptin on [³H]‐5‐HT release from rat cerebral cortex slices

1999 • 62 citations

Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice

2001 • 55 citations

Lack of the nociceptin receptor does not affect acute or chronic nociception in mice

2002 • 36 citations

Comparison of the ORL1 receptor‐mediated inhibition of noradrenaline release in human and rat neocortical slices

2002 • 26 citations

Direct and indirect inhibition by nociceptin/orphanin FQ on noradrenaline release from rodent cerebral cortex in vitro

2002 • 16 citations

Chronic paroxetine increases [3H]nociceptin binding in rat dorsal raphe nucleus

2002 • 8 citations