The extracellular regulation of bone morphogenetic protein signaling

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate

2002 • 1,437 citations

Receptors; models for binding, trafficking and signaling

1997 • 883 citations

The regulation of TGFβ signal transduction

2009 • 788 citations

A common plan for dorsoventral patterning in Bilateria

1996 • 774 citations

Silencing of TGF-β signalling by the pseudoreceptor BAMBI

1999 • 691 citations

Lipoprotein particles are required for Hedgehog and Wingless signalling

2005 • 678 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators

2002 • 602 citations

Human Bone Morphogenetic Protein 2 Contains a Heparin‐Binding Site which Modifies Its Biological Activity

1996 • 555 citations

Glypicans

2008 • 494 citations

The interpretation of morphogen gradients

2006 • 471 citations

Robustness of the BMP morphogen gradient in Drosophila embryonic patterning

2002 • 463 citations

Dpp Gradient Formation in the Drosophila Wing Imaginal Disc

2000 • 453 citations

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

1998 • 448 citations

Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases

2003 • 433 citations

Do Morphogen Gradients Arise by Diffusion?

2002 • 403 citations

Kinetics of Morphogen Gradient Formation

2007 • 398 citations

Cleavage of Chordin by Xolloid Metalloprotease Suggests a Role for Proteolytic Processing in the Regulation of Spemann Organizer Activity

1997 • 398 citations

Receptors

1993 • 391 citations

Production of a DPP Activity Gradient in the Early Drosophila Embryo through the Opposing Actions of the SOG and TLD Proteins

1997 • 350 citations

Bone morphogenetic proteins and their antagonists

2006 • 336 citations

Morpheus Unbound: Reimagining the Morphogen Gradient

2007 • 329 citations

Evo-Devo: Variations on Ancestral Themes

2008 • 323 citations

Type IV collagens regulate BMP signalling in Drosophila

2008 • 315 citations

Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

1994 • 307 citations

Twisted gastrulation is a conserved extracellular BMP antagonist

2001 • 302 citations

Drosophila Dpp Morphogen Movement Is Independent of Dynamin-Mediated Endocytosis but Regulated by the Glypican Members of Heparan Sulfate Proteoglycans

2004 • 297 citations

Facilitated Transport of a Dpp/Scw Heterodimer by Sog/Tsg Leads to Robust Patterning of the Drosophila Blastoderm Embryo

2005 • 291 citations

Shaping BMP morphogen gradients in theDrosophilaembryo and pupal wing

2005 • 288 citations

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling

2000 • 278 citations

ThreeDrosophilaEXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

2003 • 274 citations

Type IIA Procollagen Containing the Cysteine-rich Amino Propeptide Is Deposited in the Extracellular Matrix of Prechondrogenic Tissue and Binds to TGF-β1 and BMP-2

1999 • 263 citations

BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II

2000 • 261 citations

Spemann's organizer and self-regulation in amphibian embryos

2006 • 252 citations

Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field

2005 • 247 citations

HSPG Modification by the Secreted Enzyme Notum Shapes the Wingless Morphogen Gradient

2002 • 238 citations

Why cytoplasmic signalling proteins should be recruited to cell membranes

2000 • 235 citations

Targeting of Bone Morphogenetic Protein Growth Factor Complexes to Fibrillin

2008 • 232 citations

Scaling of the BMP activation gradient in Xenopus embryos

2008 • 230 citations

Comparative Genomic Analysis of the Eight-Membered Ring Cystine Knot-Containing Bone Morphogenetic Protein Antagonists

2003 • 230 citations

Embryonic Dorsal-Ventral Signaling: Secreted Frizzled-Related Proteins as Inhibitors of Tolloid Proteinases

2006 • 221 citations

Abrogation of heparan sulfate synthesis inDrosophiladisrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways

2004 • 221 citations

DRAGON, a Bone Morphogenetic Protein Co-receptor

2005 • 218 citations

Interaction between proteins localized in membranes.

1986 • 216 citations

The BMP Signaling Gradient Patterns Dorsoventral Tissues in a Temporally Progressive Manner along the Anteroposterior Axis

2008 • 214 citations

BMPER, a Novel Endothelial Cell Precursor-Derived Protein, Antagonizes Bone Morphogenetic Protein Signaling and Endothelial Cell Differentiation

2003 • 214 citations

Opposing Activities of Dally-like Glypican at High and Low Levels of Wingless Morphogen Activity

2004 • 213 citations

α2-HS Glycoprotein/Fetuin, a Transforming Growth Factor-β/Bone Morphogenetic Protein Antagonist, Regulates Postnatal Bone Growth and Remodeling

2002 • 210 citations

Heparan Sulfate Proteoglycans Retain Noggin at the Cell Surface

2002 • 209 citations

Regulation of limb patterning by extracellular microfibrils

2001 • 209 citations

Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning

2005 • 207 citations

The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors

1998 • 205 citations

Dpp receptor levels contribute to shaping the Dpp morphogen gradient in the Drosophila wing imaginal disc

1998 • 202 citations

The Prodomain of BMP-7 Targets the BMP-7 Complex to the Extracellular Matrix

2005 • 201 citations

Repulsive Guidance Molecule (RGMa), a DRAGON Homologue, Is a Bone Morphogenetic Protein Co-receptor

2005 • 195 citations

Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system

2008 • 192 citations

Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease

2005 • 191 citations

Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface

2007 • 190 citations

Domain-specific Modification of Heparan Sulfate by Qsulf1 Modulates the Binding of the Bone Morphogenetic Protein Antagonist Noggin

2004 • 190 citations

Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling

2001 • 187 citations

Mechanisms for Positional Signalling by Morphogen Transport: a Theoretical Study

1998 • 181 citations

Bone Morphogenetic Proteins Signal through the Transforming Growth Factor-β Type III Receptor

2008 • 178 citations

Formation of the BMP Activity Gradient in the Drosophila Embryo

2005 • 178 citations

Action Range of BMP Is Defined by Its N-Terminal Basic Amino Acid Core

2002 • 175 citations

glypican-3 Controls Cellular Responses to Bmp4 in Limb Patterning and Skeletal Development

2000 • 174 citations

The endocytic pathway and formation of the Wingless morphogen gradient

2005 • 174 citations

Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface

2008 • 173 citations

Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems

2002 • 172 citations

Lipoprotein-Heparan Sulfate Interactions in the Hh Pathway

2007 • 166 citations

Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction

2004 • 165 citations

The BMP-Binding Protein Crossveinless 2 Is a Short-Range, Concentration-Dependent, Biphasic Modulator of BMP Signaling in Drosophila

2008 • 163 citations

Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila

2000 • 163 citations

BMP antagonists: Their roles in development and involvement in pathophysiology

2005 • 157 citations

Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless Transcytosis

2008 • 155 citations

Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling

2001 • 153 citations

BMPER Is an Endothelial Cell Regulator and Controls Bone Morphogenetic Protein-4–Dependent Angiogenesis

2008 • 148 citations

Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation inXenopusembryos

2005 • 146 citations

Anti-Dorsalizing Morphogenetic Protein is a novel TGF-β homolog expressed in the Spemann organizer

1995 • 145 citations

Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction

2004 • 144 citations

GDF11 Forms a Bone Morphogenetic Protein 1-Activated Latent Complex That Can Modulate Nerve Growth Factor-Induced Differentiation of PC12 Cells

2005 • 144 citations

Modulation of the Binding of Matrix Gla Protein (MGP) to Bone Morphogenetic Protein-2 (BMP-2)

2000 • 141 citations

Follistatin Regulates Bone Morphogenetic Protein-7 (BMP-7) Activity to Stimulate Embryonic Muscle Growth

2002 • 135 citations

Fish are like flies are like frogs: Conservation of dorsal‐ventral patterning mechanisms

1997 • 123 citations

Wingful, an extracellular feedback inhibitor of Wingless

2002 • 121 citations

A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling

2009 • 117 citations

Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis

2006 • 116 citations

Robust, bistable patterning of the dorsal surface of the Drosophila embryo

2006 • 116 citations

TGFβ family signaling: novel insights in development and disease

2009 • 114 citations

Crystal Structure Analysis Reveals How the Chordin Family Member Crossveinless 2 Blocks BMP-2 Receptor Binding

2008 • 112 citations

Extracellular modulation of BMP activity in patterning the dorsoventral axis

2006 • 112 citations

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of theDrosophilaembryo

2003 • 109 citations

Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein

2006 • 109 citations

Creation of a Sog Morphogen Gradient in the Drosophila Embryo

2002 • 108 citations

Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation

2006 • 107 citations

von Willebrand Factor Type C Domain-containing Proteins Regulate Bone Morphogenetic Protein Signaling through Different Recognition Mechanisms

2007 • 107 citations

A New Model for Growth Factor Activation: Type II Receptors Compete with the Prodomain for BMP-7

2008 • 105 citations

Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model

2004 • 104 citations

Heparan sulfate proteoglycans at a glance

2007 • 104 citations

Robust Stability of the Embryonic Axial Pattern Requires a Secreted Scaffold for Chordin Degradation

2008 • 103 citations

Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation

2005 • 102 citations

Crossveinless-2 Is a BMP Feedback Inhibitor that Binds Chordin/BMP to Regulate Xenopus Embryonic Patterning

2008 • 100 citations

Type I receptor binding of bone morphogenetic protein 6 is dependent on N‐glycosylation of the ligand

2007 • 100 citations

Biglycan is a new extracellular component of the Chordin–BMP4 signaling pathway

2005 • 99 citations

Tsukushi Functions as an Organizer Inducer by Inhibition of BMP Activity in Cooperation with Chordin

2004 • 99 citations

CRIM1 Regulates the Rate of Processing and Delivery of Bone Morphogenetic Proteins to the Cell Surface

2003 • 98 citations

Quantitative Models of Developmental Pattern Formation

2006 • 98 citations

The function of a Drosophila glypican does not depend entirely on heparan sulfate modification

2006 • 97 citations

The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development

1996 • 93 citations

The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing

2005 • 93 citations

Glypican LON-2 Is a Conserved Negative Regulator of BMP-like Signaling in Caenorhabditis elegans

2007 • 89 citations

Tinkering with heparan sulfate sulfation to steer development

2007 • 82 citations

Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone

2005 • 81 citations

Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts

2007 • 78 citations

Matching catalytic activity to developmental function: Tolloid-related processes Sog in order to help specify the posterior crossvein in theDrosophilawing

2005 • 74 citations

Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins

2004 • 73 citations

Cell-surface Heparan Sulfate Proteoglycans Potentiate Chordin Antagonism of Bone Morphogenetic Protein Signaling and Are Necessary for Cellular Uptake of Chordin

2004 • 71 citations

Regulation of dally, an Integral Membrane Proteoglycan, and Its Function during Adult Sensory Organ Formation of Drosophila

2001 • 70 citations

Elucidation of subfamily segregation and intramolecular coevolution of the olfactomedin‐like proteins by comprehensive phylogenetic analysis and gene expression pattern assessment

2005 • 70 citations

Proline and γ-Carboxylated Glutamate Residues in Matrix Gla Protein Are Critical for Binding of Bone Morphogenetic Protein-4

2008 • 69 citations

On the role of glypicans in the process of morphogen gradient formation

2006 • 63 citations

Xenopus Kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline

2000 • 60 citations

Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog

2005 • 60 citations

A vertebrate crossveinless 2 homologue modulates BMP activity and neural crest cell migration

2004 • 60 citations

dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity

2008 • 57 citations

Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling

2002 • 57 citations

Identification of the ligand-binding site of the BMP type IA receptor for BMP-4

2000 • 54 citations

Crim1^{KST264/KST264} mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems

2006 • 53 citations

Crim1KST264/KST264 Mice Implicate Crim1 in the Regulation of Vascular Endothelial Growth Factor-A Activity during Glomerular Vascular Development

2007 • 52 citations

BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish

2007 • 52 citations

Theoretical and experimental approaches to understand morphogen gradients

2008 • 50 citations

Development of the vertebral morphogenetic field in the mouse: Interactions between Crossveinless-2 and Twisted Gastrulation

2008 • 49 citations

SITE-SPECIFIC INTERACTION OF BONE MORPHOGENETIC PROTEIN 2 WITH PROCOLLAGEN II

2002 • 49 citations

The Cysteine-Rich Domain Protein KCP Is a Suppressor of Transforming Growth Factor β/Activin Signaling in Renal Epithelia

2006 • 47 citations

A translational block to HSPG synthesis permits BMP signaling in the earlyDrosophilaembryo

2008 • 46 citations

Robustness of Embryonic Spatial Patterning in Drosophila melanogaster

2007 • 45 citations

crossveinless defines a new family of Twisted‐gastrulation‐like modulators of bone morphogenetic protein signalling

2005 • 44 citations

Regulation of BMP-induced ectopic bone formation by Ahsg

2005 • 42 citations

The Twisted gastrulation family of proteins, together with the IGFBP and CCN families, comprise the TIC superfamily of cysteine rich secreted factors

2001 • 41 citations

Analysis of dynamic morphogen scale invariance

2009 • 40 citations

Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade

2004 • 39 citations

Amelogenin binds to both heparan sulfate and bone morphogenetic protein 2 and pharmacologically suppresses the effect of noggin

2008 • 36 citations

Combinatorial signaling by Twisted Gastrulation and Decapentaplegic

1997 • 33 citations

Syndecan-1 regulates BMP signaling and dorso-ventral patterning of the ectoderm during early Xenopus development

2009 • 32 citations

Informatics approaches to understanding TGFβ pathway regulation

2009 • 31 citations

DRAGON, a GPI‐anchored membrane protein, inhibits BMP signaling in C2C12 myoblasts

2009 • 25 citations

Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development

2006 • 25 citations

Bone morphogenetic protein–2 activity is regulated by secreted phosphoprotein–24 kd, an extracellular pseudoreceptor, the gene for which maps to a region of the human genome important for bone quality

2009 • 21 citations

BMP Stimulation of Alkaline Phosphatase Activity in Pluripotent Mouse C2C12 Cells is Inhibited by Dermatopontin, One of the Most Abundant Low Molecular Weight Proteins in Demineralized Bone Matrix

2006 • 21 citations

HSPG modulation of BMP signaling in fibrodysplasia ossificans progressiva cells

2007 • 21 citations

crm-1 facilitates BMP signaling to control body size in Caenorhabditis elegans

2007 • 20 citations

Crossveinless-2 Controls Bone Morphogenetic Protein Signaling during Early Cardiomyocyte Differentiation in P19 Cells

2008 • 14 citations

Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice

2008 • 14 citations

Interpreting clone-mediated perturbations of morphogen profiles

2004 • 13 citations

Cerberus functions as a BMP agonist to synergistically induce nodal expression during left–right axis determination in the chick embryo

2008 • 13 citations

Type IV collagens and Dpp positive and negative regulators of signaling

2008 • 8 citations

The mechanism of sudden stripe formation during dorso-ventral patterning in Drosophila

2006 • 6 citations