Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators

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1990 • 87,358 citations

Bone: Formation by Autoinduction

1965 • 5,498 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]

1994 • 1,442 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

2001 • 1,111 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein

2001 • 971 citations

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

1996 • 959 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Activin-Binding Protein from Rat Ovary Is Follistatin

1990 • 886 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

1994 • 855 citations

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

1998 • 838 citations

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1999 • 833 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

1999 • 823 citations

Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton

1998 • 810 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

1996 • 757 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro.

1991 • 735 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Silencing of TGF-β signalling by the pseudoreceptor BAMBI

1999 • 691 citations

Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.

1992 • 680 citations

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

2002 • 679 citations

Bone morphogenetic proteins in development

2004 • 678 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

The Xenopus Dorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities

1998 • 649 citations

Neural induction, the default model and embryonic stem cells

2002 • 619 citations

TGF-β signaling by Smad proteins

2000 • 618 citations

Multiple defects and perinatal death in mice deficient in follistatin

1995 • 586 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

The organizer factors Chordin and Noggin are required for mouse forebrain development

2000 • 528 citations

Signal transduction by bone morphogenetic proteins

1998 • 528 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Control of C. elegans Larval Development by Neuronal Expression of a TGF-β Homolog

1996 • 516 citations

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

1995 • 510 citations

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

2001 • 506 citations

The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2

1990 • 498 citations

Thirty-seven candidate genes for polycystic ovary syndrome: Strongest evidence for linkage is with follistatin

1999 • 483 citations

The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

1992 • 483 citations

Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling

2000 • 473 citations

The family of bone morphogenetic proteins

2000 • 456 citations

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds

1999 • 455 citations

Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

1997 • 452 citations

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

1998 • 448 citations

A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin

1995 • 436 citations

Role of Ras and Mapks in TGFβ signaling

2000 • 430 citations

The establishment of spemann's organizer and patterning of the vertebrate embryo

2000 • 424 citations

Bone morphogenetic protein-3 is a negative regulator of bone density

2001 • 420 citations

TGF-β signaling by Smad proteins

2000 • 406 citations

Intracellular BMP Signaling Regulation in Vertebrates: Pathway or Network?

2001 • 401 citations

Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern

1995 • 390 citations

Bone and cartilage differentiation

1994 • 389 citations

Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family

1996 • 387 citations

The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4

1997 • 382 citations

Mice lackingBmp6 function

1998 • 363 citations

Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo

1998 • 350 citations

Production of a DPP Activity Gradient in the Early Drosophila Embryo through the Opposing Actions of the SOG and TLD Proteins

1997 • 350 citations

Ubiquitin-dependent degradation of TGF-β-activated Smad2

1999 • 343 citations

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

1999 • 341 citations

Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

1998 • 339 citations

The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb

1999 • 337 citations

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

1997 • 325 citations

TGF-β Family Signal Transduction in Drosophila Development: From Mad to Smads

1999 • 324 citations

Smad5 and DPC4 Are Key Molecules in Mediating BMP-2-induced Osteoblastic Differentiation of the Pluripotent Mesenchymal Precursor Cell Line C2C12

1998 • 319 citations

Bone morphogenetic proteins: An update on basic biology and clinical relevance

1999 • 318 citations

The status of Wnt signalling regulates neural and epidermal fates in the chick embryo

2001 • 315 citations

Neural induction: toward a unifying mechanism

2001 • 289 citations

Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo.

1993 • 283 citations

An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo

1993 • 283 citations

A Mouse Cerberus/Dan-Related Gene Family

1999 • 283 citations

Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle

2000 • 283 citations

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling

2000 • 278 citations

The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.

1996 • 274 citations

Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites

2000 • 273 citations

Bmp activity establishes a gradient of positional information throughout the entire neural plate

1999 • 266 citations

Cloning from a mouse osteoblastic cell line of a set of transforming‐growth‐factor‐β1‐regulated genes, one of which seems to encode a follistatin‐related polypeptide

1993 • 264 citations

A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3.

1995 • 250 citations

BMP5 and the Molecular, Skeletal, and Soft-Tissue Alterations in short ear Mice

1994 • 247 citations

The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor

1996 • 242 citations

A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning inCaenorhabditis elegans

1999 • 242 citations

Primary structure of the human follistatin precursor and its genomic organization.

1988 • 234 citations

BMP7 Null Mutation in Mice: Developmental Defects in Skeleton, Kidney, and Eye

1997 • 230 citations

Pioneer Axon Guidance by UNC-129, a C. elegans TGF-β

1998 • 229 citations

Embryonic Patterning: To BMP or Not to BMP, That Is the Question

1997 • 221 citations

Differential Regulation ofchordinExpression Domains in Mutant Zebrafish

1997 • 210 citations

Overexpression of Mouse Follistatin Causes Reproductive Defects in Transgenic Mice

1998 • 210 citations

Ventroptin: A BMP-4 Antagonist Expressed in a Double-Gradient Pattern in the Retina

2001 • 206 citations

Expression and Function ofGdf-5during Digit Skeletogenesis in the Embryonic Chick Leg Bud

1999 • 204 citations

'Formins': proteins deduced from the alternative transcripts of the limb deformity gene

1990 • 201 citations

Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

2001 • 198 citations

A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers

1996 • 198 citations

Bone morphogenetic proteins and their receptors: Potential functions in the brain

1998 • 189 citations

Murine Cerberus Homologue mCer-1: A Candidate Anterior Patterning Molecule

1998 • 185 citations

The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult

1998 • 184 citations

Antagonistic Signaling by Caronte , a Novel Cerberus -Related Gene, Establishes Left–Right Asymmetric Gene Expression

1999 • 179 citations

BMP signalling in early Xenopus development

1999 • 171 citations

VERTEBRATE NEURAL INDUCTION

1997 • 162 citations

A molecular mechanism enabling continuous embryonic muscle growth – a balance between proliferation and differentiation

1999 • 161 citations

Biosynthesis, Post-translation Modification, and Functional Characterization of Drm/Gremlin

2000 • 153 citations

Van Buchem Disease (Hyperostosis Corticalis Generalisata) Maps to Chromosome 17q12-q21

1998 • 152 citations

Human Follistatin-Related Protein: A Structural Homologue of Follistatin with Nuclear Localization

2001 • 141 citations

Three Different noggin Genes Antagonize the Activity of Bone Morphogenetic Proteins in the Zebrafish Embryo

1999 • 136 citations

Identification of mammalian noggin and its expression in the adult nervous system

1995 • 135 citations

Cerberus regulates left–right asymmetry of the embryonic head and heart

1999 • 133 citations

The syndromic status of sclerosteosis and van Buchem disease

1984 • 133 citations

Expression of the mousecerberus-related gene,Cerr1, suggests a role in anterior neural induction and somitogenesis

1998 • 132 citations

Localization of the Gene for Sclerosteosis to the van Buchem Disease–Gene Region on Chromosome 17q12–q21

1999 • 129 citations

Hyperostosis corticalis generalisata

1962 • 127 citations

Inhibition of noggin expression in the dorsal neural tube by somitogenesis: a mechanism for coordinating the timing of neural crest emigration

2000 • 123 citations

Genetic aspects of fibrodysplasia ossificans progressiva.

1982 • 123 citations

Identification of drm, a Novel Gene Whose Expression Is Suppressed in Transformed Cells and Which Can Inhibit Growth of Normal but Not Transformed Cells in Culture

1997 • 118 citations

Activin and Its Receptors during Gastrulation and the Later Phases of Mesoderm Development in the Chick Embryo

1995 • 117 citations

Bambi is coexpressed with Bmp-4 during mouse embryogenesis

2001 • 114 citations

FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders

1998 • 114 citations

Disruption of formin-encoding transcripts in two mutant limb deformity alleles

1990 • 110 citations

Xenopus Smad7 Inhibits both the Activin and BMP Pathways and Acts as a Neural Inducer

1998 • 109 citations

A gradient of BMP activity specifies dorsal–ventral fates in early Xenopus embryos

1999 • 107 citations

Follistatin and Noggin Are Excluded from the Zebrafish Organizer

1998 • 106 citations

Patterning the zebrafish axial skeleton requires early chordin function

1999 • 105 citations

Antagonism within and around the organizer: BMP inhibitors in vertebrate body patterning

1997 • 104 citations

Spatially Restricted Activation of the SAX Receptor by SCW Modulates DPP/TKV Signaling in Drosophila Dorsal–Ventral Patterning

1998 • 103 citations

The Wnt-activated Xiro1 gene encodes a repressor that is essential for neural development and downregulates Bmp4

2001 • 102 citations

Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis

2001 • 99 citations

DAN is a secreted glycoprotein related to Xenopus cerberus

1998 • 94 citations

Gdf11 Is a Negative Regulator of Chondrogenesis and Myogenesis in the Developing Chick Limb

2001 • 92 citations

A Novel Chordin-like Protein Inhibitor for Bone Morphogenetic Proteins Expressed Preferentially in Mesenchymal Cell Lineages

2001 • 91 citations

Mutation and Analysis of Dan, the Founding Member of the Dan Family of Transforming Growth Factor β Antagonists

2001 • 91 citations

Identification of human DAN gene, mapping to the putative neuroblastoma tumor suppressor locus.

1994 • 83 citations

Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism

2001 • 81 citations

Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells.

1995 • 81 citations

Follistatin-related protein (FSRP): a new member of the follistatin gene family

2001 • 78 citations

Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning

1995 • 76 citations

Follistatin

1998 • 74 citations

Molecular cloning and characterization of a cDNA showing negative regulation in v-src-transformed 3Y1 rat fibroblasts.

1993 • 70 citations

Coordinated Expression of Noggin and Bone Morphogenetic Proteins (BMPs) During Early Skeletogenesis and Induction of Noggin Expression by BMP-7

1999 • 68 citations

Osteopetrosis with syndactyly; a morphological variant of Albers-Schönberg's disease.

1958 • 67 citations

Characterization of a Rat C₆ Glioma‐Secreted Follistatin‐Related Protein (FRP)

1994 • 66 citations

Mouse Smad8 Phosphorylation Downstream of BMP Receptors ALK-2, ALK-3, and ALK-6 Induces Its Association with Smad4 and Transcriptional Activity

2000 • 65 citations

DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain

2000 • 63 citations

The Mouse Cer1 (Cerberus related or homologue) Gene Is Not Required for Anterior Pattern Formation

1999 • 62 citations

OSTEOPETROSIS WITH SYNDACTYLY

1958 • 62 citations

Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach

1998 • 58 citations

Opposing Effects of Activin A and Follistatin on Developing Skeletal Muscle Cells

1997 • 58 citations

Cloning and Early Dorsal Axial Expression of Flik, a Chick Follistatin-Related Gene: Evidence for Involvement in Dorsalization/Neural Induction

1996 • 56 citations

Spatiotemporal expression patterns of mammalian chordin during postgastrulation embryogenesis and in postnatal brain

2000 • 53 citations

Intracellular Signaling of the TGF‐β Superfamily by Smad Proteins

1999 • 52 citations

Neuralin-1 is a novel Chordin-related molecule expressed in the mouse neural plate

2001 • 51 citations

Identification of three novel mutations of the noggin gene in patients with fibrodysplasia ossificans progressiva

2001 • 50 citations

Localization of a Multiple Synostoses–Syndrome Disease Gene to Chromosome 17q21-22

1998 • 49 citations

In Xenopus Embryos, BMP Heterodimers Are Not Required for Mesoderm Induction, but BMP Activity Is Necessary for Dorsal/Ventral Patterning

1999 • 40 citations

Localization of the Gene (SYM1) for Proximal Symphalangism to Human Chromosome 17q21-q22

1995 • 38 citations

Effects of the short ear gene in the mouse on cartilage formation in healing bone fractures

1958 • 36 citations

Role of the follistatin gene in women with polycystic ovary syndrome

2001 • 34 citations

Coding Sequence and Expression Patterns of Mouse Chordin and Mapping of the Cognate MouseChrdand HumanCHRDGenes

1998 • 33 citations

The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities

2001 • 30 citations

Localization of the gene for fibrodysplasia ossificans progressiva (FOP) to chromosome 17q21-22.

2000 • 27 citations

Expression pattern of the drm/gremlin gene during chicken embryonic development

2001 • 24 citations

Genomic organisation of the human chordin gene and mutation screening of candidate Cornelia de Lange syndrome genes

1999 • 21 citations

Xenopus Dan, a member of the Dan gene family of BMP antagonists, is expressed in derivatives of the cranial and trunk neural crest

2001 • 21 citations

The BMP antagonists cerberus-like and noggin do not interact during mouse forebrain development.

2001 • 12 citations

Assignment<footref rid="foot01"><sup>1</sup></footref> of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2→q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH

1999 • 11 citations

Is Chordin a morphogen?

2001 • 7 citations

HumancerberusRelated GeneCER1Maps to Chromosome 9

1999 • 6 citations