Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Effective targeted gene ‘knockdown’ in zebrafish

2000 • 2,464 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

The Zebrafish Book : A Guide for the Laboratory Use of Zebrafish

2000 • 744 citations

Bone morphogenetic proteins in development

2004 • 678 citations

DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS

2004 • 652 citations

Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators

2002 • 602 citations

Intraembryonic hematopoietic cell migration during vertebrate development.

1995 • 600 citations

Human Bone Morphogenetic Protein 2 Contains a Heparin‐Binding Site which Modifies Its Biological Activity

1996 • 555 citations

Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins

1998 • 541 citations

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning

1997 • 518 citations

Molecular Genetics of Axis Formation in Zebrafish

2005 • 473 citations

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

1998 • 448 citations

Laser-induced gene expression in specific cells of transgenic zebrafish

2000 • 433 citations

The establishment of spemann's organizer and patterning of the vertebrate embryo

2000 • 424 citations

Ventral and Lateral Regions of the Zebrafish Gastrula, Including the Neural Crest Progenitors, Are Established by abmp2b/swirlPathway of Genes

1998 • 424 citations

Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes

1996 • 408 citations

Cleavage of Chordin by Xolloid Metalloprotease Suggests a Role for Proteolytic Processing in the Regulation of Spemann Organizer Activity

1997 • 398 citations

dino and mercedes, two genes regulating dorsal development in the zebrafish embryo

1996 • 325 citations

Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish

1996 • 323 citations

Twisted gastrulation is a conserved extracellular BMP antagonist

2001 • 302 citations

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling

2000 • 278 citations

Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation

2000 • 269 citations

BMP-binding modules in chordin: a model for signalling regulation in the extracellular space

2000 • 244 citations

Expression of two zebrafish orthodenticle-related genes in the embryonic brain

1994 • 227 citations

Dally regulates Dpp morphogen gradient formation in theDrosophilawing

2003 • 223 citations

BMPER, a Novel Endothelial Cell Precursor-Derived Protein, Antagonizes Bone Morphogenetic Protein Signaling and Endothelial Cell Differentiation

2003 • 214 citations

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.

1996 • 213 citations

Conservation of BMP signaling in zebrafish mesoderm patterning

1997 • 210 citations

Heparan Sulfate Proteoglycans Retain Noggin at the Cell Surface

2002 • 209 citations

Molecular recognition of BMP-2 and BMP receptor IA

2004 • 205 citations

Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo

2000 • 202 citations

Twisted gastrulation can function as a BMP antagonist

2001 • 202 citations

The ventral and posterior expression of the zebrafish homeobox gene eve1 is perturbed in dorsalized and mutant embryos

1993 • 196 citations

The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo

1999 • 193 citations

Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease

2005 • 191 citations

lockjawencodes a zebrafishtfap2arequired for early neural crest development

2003 • 190 citations

Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling

2001 • 187 citations

Cleavage of the BMP-4 Antagonist Chordin by Zebrafish Tolloid

1997 • 187 citations

Local inhibition and long-range enhancement of Dpp signal transduction by Sog

1999 • 185 citations

Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems

2002 • 172 citations

Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila

2000 • 163 citations

The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo

2001 • 153 citations

Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling

2001 • 153 citations

lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation

2001 • 152 citations

Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction

2004 • 144 citations

Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development

2005 • 143 citations

The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo

1999 • 123 citations

From receptor to nucleus: the Smad pathway

1997 • 110 citations

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of theDrosophilaembryo

2003 • 109 citations

Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling

2003 • 109 citations

Loss of cerebum function ventralizes the zebrafish embryo

1997 • 81 citations

Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation

2004 • 79 citations

Dorsoventral Patterning in the Zebrafish: Bone Morphogenetic Proteins and Beyond

2002 • 76 citations

Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins

2004 • 73 citations

The pro-BMP activity of Twisted gastrulation is independent of BMP binding

2003 • 71 citations

Cell-surface Heparan Sulfate Proteoglycans Potentiate Chordin Antagonism of Bone Morphogenetic Protein Signaling and Are Necessary for Cellular Uptake of Chordin

2004 • 71 citations

Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside

2000 • 67 citations

Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms

2004 • 67 citations

Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning

2004 • 66 citations

WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation

2005 • 66 citations

A positive role for Short gastrulation in modulating BMP signaling during dorsoventral patterning in theDrosophilaembryo

2001 • 61 citations

Xenopus Kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline

2000 • 60 citations

A vertebrate crossveinless 2 homologue modulates BMP activity and neural crest cell migration

2004 • 60 citations

Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling

2002 • 57 citations

Modulation of BMP Activity in Dorsal-Ventral Pattern Formation by the Chordin and Ogon Antagonists

2002 • 56 citations

Neuralin-1 is a novel Chordin-related molecule expressed in the mouse neural plate

2001 • 51 citations

The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein

2003 • 49 citations

Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade

2004 • 39 citations

Carboxypeptidase Z Is Present in the Regulated Secretory Pathway and Extracellular Matrix in Cultured Cells and in Human Tissues

2000 • 38 citations