Quantitative Models of Developmental Pattern Formation

The chemical basis of morphogenesis

1952 • 11,233 citations

A theory of biological pattern formation

1972 • 3,055 citations

Models of biological pattern formation

1982 • 1,851 citations

The segment polarity network is a robust developmental module

2000 • 1,177 citations

A synthetic multicellular system for programmed pattern formation

2005 • 1,166 citations

Evolvability

1998 • 1,051 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Transcriptional regulation by the numbers: models

2005 • 776 citations

Morphogen gradient interpretation

2001 • 738 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome

2002 • 619 citations

Sensitivity Analysis for Chemical Models

2005 • 617 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Mechanical feedback as a possible regulator of tissue growth

2005 • 605 citations

Dynamic control of positional information in the early Drosophila embryo

2004 • 577 citations

A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis

2005 • 541 citations

Establishment of developmental precision and proportions in the early Drosophila embryo

2002 • 496 citations

The interpretation of morphogen gradients

2006 • 471 citations

Robustness of the BMP morphogen gradient in Drosophila embryonic patterning

2002 • 463 citations

Dpp Gradient Formation in the Drosophila Wing Imaginal Disc

2000 • 453 citations

Morphogens, their identification and regulation

2004 • 437 citations

Transcriptional regulation by the numbers: applications

2005 • 404 citations

Do Morphogen Gradients Arise by Diffusion?

2002 • 403 citations

Fidelity in planar cell polarity signalling

2003 • 320 citations

Diffusion and scaling during early embryonic pattern formation

2005 • 311 citations

PLANAR CELL POLARIZATION: An Emerging Model Points in the Right Direction

2005 • 309 citations

Mathematical Modeling of Planar Cell Polarity to Understand Domineering Nonautonomy

2005 • 302 citations

Drosophila Dpp Morphogen Movement Is Independent of Dynamin-Mediated Endocytosis but Regulated by the Glypican Members of Heparan Sulfate Proteoglycans

2004 • 297 citations

Whole-Genome Analysis of Dorsal-Ventral Patterning in the Drosophila Embryo

2002 • 295 citations

Facilitated Transport of a Dpp/Scw Heterodimer by Sog/Tsg Leads to Robust Patterning of the Drosophila Blastoderm Embryo

2005 • 291 citations

Polarized Transport of Frizzled along the Planar Microtubule Arrays in Drosophila Wing Epithelium

2006 • 280 citations

One hundred years of positional information

1996 • 269 citations

Dynamical Analysis of Regulatory Interactions in the Gap Gene System of Drosophila melanogaster

2004 • 258 citations

A dynamic view of cellular processes by in vivo fluorescence auto- and cross-correlation spectroscopy

2003 • 248 citations

Computational detection of genomic cis- regulatory modules applied to body patterning in the early Drosophila embryo

2002 • 231 citations

Genomic Regulatory Networks and Animal Development

2005 • 225 citations

Patterns and Interfaces in Dissipative Dynamics

2006 • 221 citations

Computational representation of developmental genetic regulatory networks

2005 • 220 citations

Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning

2005 • 207 citations

7 EGF Receptor Signaling in Drosophila Oogenesis

1998 • 206 citations

Dpp receptor levels contribute to shaping the Dpp morphogen gradient in the Drosophila wing imaginal disc

1998 • 202 citations

Barrier certificates for nonlinear model validation

2005 • 198 citations

Genetic Control of Adult Pigment Stripe Development in Zebrafish

1995 • 197 citations

Kinetic Analysis of Smad Nucleocytoplasmic Shuttling Reveals a Mechanism for Transforming Growth Factor β-Dependent Nuclear Accumulation of Smads

2005 • 189 citations

Reverse Engineering the Gap Gene Network of Drosophila melanogaster

2006 • 186 citations

Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene

2006 • 180 citations

Formation of the BMP Activity Gradient in the Drosophila Embryo

2005 • 178 citations

Diffusion and Chemical Transformation

1973 • 176 citations

The endocytic pathway and formation of the Wingless morphogen gradient

2005 • 174 citations

A regulatory code for neurogenic gene expression in theDrosophilaembryo

2004 • 172 citations

Computational Models for Neurogenic Gene Expression in the Drosophila Embryo

2006 • 170 citations

Regulatory Principles of Developmental Signaling

2002 • 155 citations

Do We Understand Development?

1994 • 154 citations

The Sonic Hedgehog Signaling System as a Bistable Genetic Switch

2004 • 141 citations

Formation of the adult pigment pattern in zebrafish requiresleopardandobelixdependent cell interactions

2003 • 139 citations

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

2004 • 138 citations

Bicoid Determines Sharp and Precise Target Gene Expression in the Drosophila Embryo

2005 • 136 citations

Signal Processing in the TGF-β Superfamily Ligand-Receptor Network

2006 • 135 citations

A Simple Molecular Complex Mediates Widespread BMP-Induced Repression during Drosophila Development

2004 • 134 citations

Zebrafish Leopard gene as a component of the putative reaction-diffusion system

1999 • 128 citations

Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region

2001 • 126 citations

Engineering Gene Networks to Emulate Drosophila Embryonic Pattern Formation

2005 • 123 citations

D-cbl, a Negative Regulator of the Egfr Pathway, Is Required for Dorsoventral Patterning in Drosophila Oogenesis

2000 • 122 citations

Signal dynamics in Sonic hedgehog tissue patterning

2006 • 118 citations

Robust, bistable patterning of the dorsal surface of the Drosophila embryo

2006 • 116 citations

Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation

2006 • 107 citations

Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model

2004 • 104 citations

Threshold responses to morphogen gradients by zero‐order ultrasensitivity

2005 • 102 citations

Elucidating mechanisms underlying robustness of morphogen gradients

2004 • 101 citations

Model-Based Experimental Analysis of Kinetic Phenomena in Multi-Phase Reactive Systems

2005 • 94 citations

Cross-species comparison significantly improves genome-wide prediction of cis-regulatory modules in Drosophila

2004 • 90 citations

Evolutionary diversification of pigment pattern inDaniofishes:differentialfmsdependence and stripe loss inD. albolineatus

2004 • 90 citations

Lumenal Transmission of Decapentaplegic in Drosophila Imaginal Discs

2002 • 87 citations

Quantifying the Gurken Morphogen Gradient in Drosophila Oogenesis

2006 • 86 citations

Long‐range coordination of planar polarity in Drosophila

2005 • 85 citations

Establishment and maintenance of planar epithelial cell polarity by asymmetric cadherin bridges: A computer model

2005 • 83 citations

Morphogen Transport along Epithelia, an Integrated Trafficking Problem

2002 • 82 citations

Regulation of BMP and Activin Signaling in Drosophila

2003 • 69 citations

Determination of Complex Reaction Mechanisms. Analysis of Chemical, Biological and Genetic Networks

2008 • 67 citations

Computational methods for transcriptional regulation

2005 • 64 citations

Advanced Methods and Algorithms for Biological Networks Analysis

2006 • 64 citations

Mathematical model of morphogen electrophoresis through gap junctions

2006 • 62 citations

Dpp-responsive Silencers Are Bound by a Trimeric Mad-Medea Complex

2005 • 59 citations

Intercellular coupling amplifies fate segregation during Caenorhabditis elegans vulval development

2006 • 58 citations

Postsynaptic Mad Signaling at the Drosophila Neuromuscular Junction

2006 • 57 citations

Gradients and thresholds: BMP response gradients unveiled in Drosophila embryos

2003 • 56 citations

Mosaic analyses reveal the function ofDrosophila Rasin embryonic dorsoventral patterning and dorsal follicle cell morphogenesis

2002 • 51 citations

Smad Affinity Can Direct Distinct Readouts of the Embryonic Extracellular Dpp Gradient in Drosophila

2004 • 50 citations

Discrete Models of Autocrine Cell Communication in Epithelial Layers

2003 • 49 citations

Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription

2001 • 46 citations

Mechanisms of Gurken-dependentpiperegulation and the robustness of dorsoventral patterning inDrosophila

2002 • 44 citations

Computational analysis of EGFR inhibition by Argos

2005 • 42 citations

Drosophila peripodial cells, more than meets the eye?

2001 • 36 citations

Generating and interpreting the Brinker gradient in the Drosophila wing

2005 • 36 citations

Role of Gap Genes in Early Drosophila Development

1990 • 34 citations

Signaling interactions between squamous and columnar epithelia of the Drosophila wing disc

2005 • 30 citations

Ligand trapping in epithelial layers and cell cultures

2004 • 21 citations

Biological Development of Cell Patterns: Characterizing the Space of Cell Chemistry Genetic Regulatory Networks

2005 • 20 citations

Constructing quantitative models from qualitative mutant phenotypes: preferences in selecting sensory organ precursors

2006 • 16 citations

On the spread of morphogens

2004 • 15 citations

An asymptotic study of the inductive pattern formation mechanism in Drosophila egg development

2003 • 13 citations

Special Issue on Uncertainty Quantification

2004 • 9 citations