Domain-specific Modification of Heparan Sulfate by Qsulf1 Modulates the Binding of the Bone Morphogenetic Protein Antagonist Noggin

Functions of Cell Surface Heparan Sulfate Proteoglycans

1999 • 2,660 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

1998 • 838 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

Specificities of heparan sulphate proteoglycans in developmental processes

2000 • 706 citations

Regulation of Wnt Signaling and Embryo Patterning by an Extracellular Sulfatase

2001 • 462 citations

QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling

2003 • 424 citations

Bone morphogenetic proteins in the nervous system

1997 • 409 citations

Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans

2002 • 404 citations

Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus

1997 • 332 citations

Domain Structure of Heparan Sulfates from Bovine Organs

1996 • 281 citations

Heparan Sulfate Oligosaccharides Require 6-O-Sulfation for Promotion of Basic Fibroblast Growth Factor Mitogenic Activity

1998 • 276 citations

Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning

1997 • 266 citations

Sulfated Polysaccharides Enhance the Biological Activities of Bone Morphogenetic Proteins

2003 • 262 citations

Molecular distinctions between heparan sulphate and heparin. Analysis of sulphation patterns indicates that heparan sulphate and heparin are separate families of N-sulphated polysaccharides

1985 • 243 citations

dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen, Dpp

1997 • 241 citations

Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin

1999 • 214 citations

Heparan Sulfate Proteoglycans Retain Noggin at the Cell Surface

2002 • 209 citations

glypican-3 Controls Cellular Responses to Bmp4 in Limb Patterning and Skeletal Development

2000 • 174 citations

Cerebellar proteoglycans regulate sonic hedgehog responses during development

2002 • 155 citations

Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition

2001 • 145 citations

Highly Sensitive Sequencing of the Sulfated Domains of Heparan Sulfate

1999 • 128 citations

Heparan Sulfate Undergoes Specific Structural Changes during the Progression from Human Colon Adenoma to Carcinoma in Vitro

1998 • 125 citations

Heparan sulfate is required for bone morphogenetic protein-7 signaling

2003 • 117 citations

Regulation of FGF-1 mitogenic activity by heparan sulfate oligosaccharides is dependent on specific structural features: differential requirements for the modulation of FGF-1 and FGF-2

2000 • 116 citations

Somitogenesis Controlled by Noggin

1998 • 110 citations

A gradient of BMP activity specifies dorsal–ventral fates in early Xenopus embryos

1999 • 107 citations

Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissues.

1997 • 104 citations

Elucidation of the Structural Features of Heparan Sulfate Important for Interaction with the Hep-2 Domain of Fibronectin

2000 • 86 citations

Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates

2003 • 40 citations