Heparan sulfate proteoglycans at a glance

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate

2002 • 1,437 citations

Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

2000 • 1,146 citations

An LDL-receptor-related protein mediates Wnt signalling in mice

2000 • 1,080 citations

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

2002 • 892 citations

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

2000 • 870 citations

Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines

2003 • 756 citations

Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury

2002 • 734 citations

Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

1997 • 731 citations

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

2000 • 679 citations

Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

1999 • 672 citations

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

2003 • 518 citations

Basement membrane proteoglycans: from cellar to ceiling

2005 • 497 citations

Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

1999 • 478 citations

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

1999 • 474 citations

Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses

2005 • 462 citations

Interactions between heparan sulfate and proteins: the concept of specificity

2006 • 446 citations

The Zebrafish Glypican Knypek Controls Cell Polarity during Gastrulation Movements of Convergent Extension

2001 • 446 citations

Glypican-3 Promotes the Growth of Hepatocellular Carcinoma by Stimulating Canonical Wnt Signaling

2005 • 429 citations

Glypican-3 as a Serum Marker for Hepatocellular Carcinoma

2005 • 426 citations

Syndecans

2005 • 426 citations

Heparin is essential for the storage of specific granule proteases in mast cells

1999 • 422 citations

Argosomes

2001 • 413 citations

Syndecans: proteoglycan regulators of cell-surface microdomains?

2003 • 409 citations

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

1999 • 393 citations

Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice

2000 • 366 citations

Syndecan-4 signals cooperatively with integrins in a Rhodependent manner in the assembly of focal adhesions and actin stress fibers

1999 • 360 citations

The Molecular Diversity of Glycosaminoglycans Shapes Animal Development

2006 • 335 citations

Unconventional Secretory Routes: Direct Protein Export Across the Plasma Membrane of Mammalian Cells

2005 • 332 citations

Syndecan-4 Proteoglycan Regulates the Distribution and Activity of Protein Kinase C

1997 • 278 citations

ThreeDrosophilaEXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

2003 • 274 citations

Ext1-Dependent Heparan Sulfate Regulates the Range of Ihh Signaling during Endochondral Ossification

2004 • 273 citations

Heparan Sulfate in trans Potentiates VEGFR-Mediated Angiogenesis

2006 • 254 citations

The HSPGs Syndecan and Dallylike Bind the Receptor Phosphatase LAR and Exert Distinct Effects on Synaptic Development

2006 • 249 citations

dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen, Dpp

1997 • 241 citations

The syndecan-1 ectodomain regulates αvβ3 integrin activity in human mammary carcinoma cells

2004 • 234 citations

Distinct and collaborative roles ofDrosophilaEXT family proteins in morphogen signalling and gradient formation

2004 • 228 citations

Abrogation of heparan sulfate synthesis inDrosophiladisrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways

2004 • 221 citations

Drosophilaglypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

2005 • 216 citations

Opposing Activities of Dally-like Glypican at High and Low Levels of Wingless Morphogen Activity

2004 • 213 citations

Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members

2007 • 203 citations

Syndecan Recyling Is Controlled by Syntenin-PIP2 Interaction and Arf6

2005 • 203 citations

Axonal Heparan Sulfate Proteoglycans Regulate the Distribution and Efficiency of the Repellent Slit during Midline Axon Guidance

2004 • 191 citations

Role of glypican 4 in the regulation of convergent extension movements during gastrulation inXenopus laevis

2003 • 179 citations

Action Range of BMP Is Defined by Its N-Terminal Basic Amino Acid Core

2002 • 175 citations

glypican-3 Controls Cellular Responses to Bmp4 in Limb Patterning and Skeletal Development

2000 • 174 citations

The endocytic pathway and formation of the Wingless morphogen gradient

2005 • 174 citations

The Molecular Phenotype of Heparan Sulfate in theHs2st−/− Mutant Mouse

2001 • 173 citations

Drosophila Perlecan modulates FGF and Hedgehog signals to activate neural stem cell division

2003 • 166 citations

Spatial Regulation of Wingless Morphogen Distribution and Signaling by Dally-like Protein

2004 • 164 citations

Heparan Sulfate Proteoglycans as Adhesive and Anti-invasive Molecules

1998 • 163 citations

Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes

2002 • 161 citations

Cell-surface heparan sulfate proteoglycans are essential components of the unconventional export machinery of FGF-2

2006 • 155 citations

Glypicans shunt the Wingless signal between local signalling and further transport

2005 • 148 citations

Syndecan-1-mediated cell spreading requires signaling by αvβ3 integrins in human breast carcinoma cells

2003 • 143 citations

The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis ofDrosophila

2003 • 142 citations

Heparan Sulfate Core Proteins in Cell-Cell Signaling

2003 • 140 citations

Plasminogen Activator Inhibitor-1 Supports IL-8-Mediated Neutrophil Transendothelial Migration by Inhibition of the Constitutive Shedding of Endothelial IL-8/Heparan Sulfate/Syndecan-1 Complexes

2003 • 135 citations

Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling

2006 • 131 citations

Glycosylphosphatidylinositol-anchored proteins: structure, function, and cleavage by phosphatidylinositol-specific phospholipase C

2002 • 126 citations

PKCα-dependent activation of RhoA by syndecan-4 during focal adhesion formation

2006 • 126 citations

When sugars guide axons: insights from heparan sulphate proteoglycan mutants

2004 • 116 citations

Direct Binding of Syndecan-4 Cytoplasmic Domain to the Catalytic Domain of Protein Kinase Cα (PKCα) Increases Focal Adhesion Localization of PKCα

2003 • 115 citations

Syndecan-1 regulates αvβ5 integrin activity in B82L fibroblasts

2006 • 109 citations

The function of a Drosophila glypican does not depend entirely on heparan sulfate modification

2006 • 97 citations

UNC-52/Perlecan affects gonadal leader cell migrations in c. elegans hermaphrodites through alterations in growth factor signaling

2003 • 85 citations

Identification of an Invasion Regulatory Domain within the Core Protein of Syndecan-1

2004 • 56 citations

Spermatid-specific promoter of the SP-10 gene functions as an insulator in somatic cells

2003 • 42 citations

Syndecan recycling is controlled by syntenin-PIP2 interaction and Arf6 (vol 9, pg 377, 2005)

2005 • 37 citations