The BMP-Binding Protein Crossveinless 2 Is a Short-Range, Concentration-Dependent, Biphasic Modulator of BMP Signaling in Drosophila

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

1998 • 448 citations

Wingless gradient formation in the Drosophila wing

2000 • 437 citations

Hedgehog Creates a Gradient of DPP Activity in Drosophila Wing Imaginal Discs

2000 • 402 citations

Nodal Signals to Smads through Cripto-Dependent and Cripto-Independent Mechanisms

2001 • 377 citations

Morpheus Unbound: Reimagining the Morphogen Gradient

2007 • 329 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

Asymmetric Rab11 Endosomes Regulate Delta Recycling and Specify Cell Fate in the Drosophila Nervous System

2005 • 306 citations

Twisted gastrulation is a conserved extracellular BMP antagonist

2001 • 302 citations

Drosophila Dpp Morphogen Movement Is Independent of Dynamin-Mediated Endocytosis but Regulated by the Glypican Members of Heparan Sulfate Proteoglycans

2004 • 297 citations

Facilitated Transport of a Dpp/Scw Heterodimer by Sog/Tsg Leads to Robust Patterning of the Drosophila Blastoderm Embryo

2005 • 291 citations

Shaping BMP morphogen gradients in theDrosophilaembryo and pupal wing

2005 • 288 citations

ThreeDrosophilaEXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

2003 • 274 citations

Identification of disulfide-bridged substructures within human von Willebrand factor

1987 • 262 citations

TGF-β Signaling Activates Steroid Hormone Receptor Expression during Neuronal Remodeling in the Drosophila Brain

2003 • 230 citations

Distinct and collaborative roles ofDrosophilaEXT family proteins in morphogen signalling and gradient formation

2004 • 228 citations

Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila

1998 • 218 citations

BMPER, a Novel Endothelial Cell Precursor-Derived Protein, Antagonizes Bone Morphogenetic Protein Signaling and Endothelial Cell Differentiation

2003 • 214 citations

Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning

2005 • 207 citations

Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease

2005 • 191 citations

Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila

2000 • 163 citations

TGF-β/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing

1998 • 156 citations

Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction

2004 • 144 citations

Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis

2006 • 116 citations

Robust, bistable patterning of the dorsal surface of the Drosophila embryo

2006 • 116 citations

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of theDrosophilaembryo

2003 • 109 citations

Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation

2006 • 107 citations

von Willebrand Factor Type C Domain-containing Proteins Regulate Bone Morphogenetic Protein Signaling through Different Recognition Mechanisms

2007 • 107 citations

The function of a Drosophila glypican does not depend entirely on heparan sulfate modification

2006 • 97 citations

The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development

1996 • 93 citations

The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing

2005 • 93 citations

Cripto Binds Transforming Growth Factor β (TGF-β) and Inhibits TGF-β Signaling

2006 • 92 citations

Context-dependent relationships between the BMPsgbbanddppduring development of theDrosophilawing imaginal disk

2001 • 89 citations

Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone

2005 • 81 citations

Matching catalytic activity to developmental function: Tolloid-related processes Sog in order to help specify the posterior crossvein in theDrosophilawing

2005 • 74 citations

Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins

2004 • 73 citations

Regulation of dally, an Integral Membrane Proteoglycan, and Its Function during Adult Sensory Organ Formation of Drosophila

2001 • 70 citations

Cripto Binds Transforming Growth Factor β (TGF-β) and Inhibits TGF-β Signaling

2008 • 68 citations

Xenopus Kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline

2000 • 60 citations

A vertebrate crossveinless 2 homologue modulates BMP activity and neural crest cell migration

2004 • 60 citations

Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling

2002 • 57 citations

Identification of the ligand-binding site of the BMP type IA receptor for BMP-4

2000 • 54 citations

Comprehensive identification of Drosophila dorsal–ventral patterning genes using a whole-genome tiling array

2006 • 54 citations

BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish

2007 • 52 citations

The Cysteine-Rich Domain Protein KCP Is a Suppressor of Transforming Growth Factor β/Activin Signaling in Renal Epithelia

2006 • 47 citations

crossveinless defines a new family of Twisted‐gastrulation‐like modulators of bone morphogenetic protein signalling

2005 • 44 citations

Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade

2004 • 39 citations

The Low pH in Trans-Golgi Triggers Autocatalytic Cleavage of Pre-α-inhibitor Heavy Chain Precursor

2000 • 30 citations

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