Morpheus Unbound: Reimagining the Morphogen Gradient

The chemical basis of morphogenesis

1952 • 11,233 citations

A theory of biological pattern formation

1972 • 3,055 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

What Is Life

1944 • 2,479 citations

Random walks in biology

1983 • 2,394 citations

Secreted antagonists of the Wnt signalling pathway

2003 • 1,543 citations

A Genomic Regulatory Network for Development

2002 • 1,538 citations

An amplified sensitivity arising from covalent modification in biological systems.

1981 • 1,211 citations

Reverse Engineering of Biological Complexity

2002 • 1,192 citations

The segment polarity network is a robust developmental module

2000 • 1,177 citations

Robustness of Cellular Functions

2004 • 1,051 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

1999 • 772 citations

Functions of heparan sulfate proteoglycans in cell signaling during development

2004 • 659 citations

DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS

2004 • 652 citations

Pattern formation by local self-activation and lateral inhibition

2000 • 611 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Cytonemes

1999 • 602 citations

Dynamic control of positional information in the early Drosophila embryo

2004 • 577 citations

Regulation of even-skipped stripe 2 in the Drosophila embryo.

1992 • 522 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo

1992 • 480 citations

Molecular Genetics of Axis Formation in Zebrafish

2005 • 473 citations

The interpretation of morphogen gradients

2006 • 471 citations

Robustness of the BMP morphogen gradient in Drosophila embryonic patterning

2002 • 463 citations

Dpp Gradient Formation in the Drosophila Wing Imaginal Disc

2000 • 453 citations

Morphogens, their identification and regulation

2004 • 437 citations

Argosomes

2001 • 413 citations

Do Morphogen Gradients Arise by Diffusion?

2002 • 403 citations

Stochastic focusing: Fluctuation-enhanced sensitivity of intracellular regulation

2000 • 393 citations

Computational modeling of the EGF-receptor system: a paradigm for systems biology

2002 • 349 citations

Diffusion and scaling during early embryonic pattern formation

2005 • 311 citations

De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia

2005 • 307 citations

The Nodal Precursor Acting via Activin Receptors Induces Mesoderm by Maintaining a Source of Its Convertases and BMP4

2006 • 307 citations

Twisted gastrulation is a conserved extracellular BMP antagonist

2001 • 302 citations

Drosophila Dpp Morphogen Movement Is Independent of Dynamin-Mediated Endocytosis but Regulated by the Glypican Members of Heparan Sulfate Proteoglycans

2004 • 297 citations

Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients

2003 • 292 citations

Shaping BMP morphogen gradients in theDrosophilaembryo and pupal wing

2005 • 288 citations

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

2004 • 283 citations

The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor

1996 • 242 citations

Potential for Control of Signaling Pathways via Cell Size and Shape

2006 • 226 citations

Dally regulates Dpp morphogen gradient formation in theDrosophilawing

2003 • 223 citations

Boundaries in Development: Formation and Function

2001 • 214 citations

Coupling segmentation to axis formation

2004 • 211 citations

Regulation of Cell Proliferation by a Morphogen Gradient

2005 • 209 citations

Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning

2005 • 207 citations

The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors

1998 • 205 citations

Robustness, Flexibility, and the Role of Lateral Inhibition in the Neurogenic Network

2002 • 204 citations

Topology and Robustness in the Drosophila Segment Polarity Network

2004 • 192 citations

Cellular metabolism and activation of retinoids: roles of cellular retinoid‐binding proteins ²

1993 • 183 citations

Mechanisms for Positional Signalling by Morphogen Transport: a Theoretical Study

1998 • 181 citations

Formation of the BMP Activity Gradient in the Drosophila Embryo

2005 • 178 citations

Geometric and viscous components of the tortuosity of the extracellular space in the brain

1998 • 178 citations

The endocytic pathway and formation of the Wingless morphogen gradient

2005 • 174 citations

The role ofbrinkerin mediating the graded response to Dpp in earlyDrosophilaembryos

1999 • 168 citations

The Sonic Hedgehog Signaling System as a Bistable Genetic Switch

2004 • 141 citations

Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo

2004 • 141 citations

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

2004 • 138 citations

Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region

2001 • 126 citations

Interpretation of a BMP Activity Gradient in Drosophila Embryos Depends on Synergistic Signaling by Two Type I Receptors, SAX and TKV

1998 • 122 citations

Endocytosis Controls Spreading and Effective Signaling Range of Fgf8 Protein

2004 • 122 citations

Signal dynamics in Sonic hedgehog tissue patterning

2006 • 118 citations

Modeling and computational analysis of EGF receptor-mediated cell communication inDrosophilaoogenesis

2002 • 118 citations

Robust, bistable patterning of the dorsal surface of the Drosophila embryo

2006 • 116 citations

Formation of morphogen gradients in the Drosophila wing

1999 • 115 citations

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of theDrosophilaembryo

2003 • 109 citations

Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model

2004 • 104 citations

Threshold responses to morphogen gradients by zero‐order ultrasensitivity

2005 • 102 citations

Morphogen gradients, positional information, and Xenopus: Interplay of theory and experiment

2002 • 101 citations

Robust Formation of Morphogen Gradients

2005 • 101 citations

Design and constraints of the Drosophila segment polarity module: Robust spatial patterning emerges from intertwined cell state switches

2002 • 100 citations

Quantitative Models of Developmental Pattern Formation

2006 • 98 citations

Regulating morphogen gradients in the Drosophila wing

2002 • 97 citations

The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development

1996 • 93 citations

A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation

1999 • 90 citations

The progeny of wingless-expressing cells deliver the signal at a distance in Drosophila embryos

2000 • 87 citations

Modeling the Cell's Guidance System

2002 • 86 citations

Quantifying the Gurken Morphogen Gradient in Drosophila Oogenesis

2006 • 86 citations

Cell-surface co-receptors: emerging roles in signaling and human disease

2005 • 76 citations

BMP, Wnt and Hedgehog signals: how far can they go?

2000 • 72 citations

Release and trafficking of lipid-linked morphogens

2005 • 66 citations

Morphogens: how big is the big picture?

2001 • 61 citations

Morphogen gradients

2000 • 49 citations

A Calculus of Purpose

2004 • 48 citations

crossveinless defines a new family of Twisted‐gastrulation‐like modulators of bone morphogenetic protein signalling

2005 • 44 citations

Pattern formation and nuclear divisions are uncoupled in Drosophila segmentation: comparison of spatially discrete and continuous models

2004 • 43 citations

Adaptation and Novelty

2016 • 41 citations

Signalling at a distance: Transport of Wingless in the embryonic epidermis of Drosophila

1999 • 38 citations

Isolation of Mutations that Disrupt Cooperative DNA Binding by the Drosophila Bicoid Protein

2001 • 32 citations

Accurate Reading of Morphogen Concentrations by Nuclear Receptors: a Formal Model of Complex Transduction Pathways

1996 • 22 citations

Aggregation of a Distributed Source in Morphogen Gradient Formation

2005 • 15 citations

Reaction-diffusion equations for simulation of calcium signalling in cell systems.

2005 • 6 citations