Lipoprotein-Heparan Sulfate Interactions in the Hh Pathway

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

The Hedgehog Response Network: Sensors, Switches, and Routers

2004 • 821 citations

Morphogen gradient interpretation

2001 • 738 citations

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

1998 • 735 citations

Lipoprotein particles are required for Hedgehog and Wingless signalling

2005 • 678 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

2001 • 514 citations

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

1999 • 474 citations

The interpretation of morphogen gradients

2006 • 471 citations

Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal

2001 • 462 citations

Wingless gradient formation in the Drosophila wing

2000 • 437 citations

Argosomes

2001 • 413 citations

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

1999 • 393 citations

Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

1999 • 374 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

Measuring dimensions: the regulation of size and shape

2000 • 358 citations

Drosophila Dpp Morphogen Movement Is Independent of Dynamin-Mediated Endocytosis but Regulated by the Glypican Members of Heparan Sulfate Proteoglycans

2004 • 297 citations

ThreeDrosophilaEXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

2003 • 274 citations

dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen, Dpp

1997 • 241 citations

Drosophilaglypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

2004 • 237 citations

The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation

2006 • 230 citations

Distinct and collaborative roles ofDrosophilaEXT family proteins in morphogen signalling and gradient formation

2004 • 228 citations

Dally regulates Dpp morphogen gradient formation in theDrosophilawing

2003 • 223 citations

Drosophilaglypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

2005 • 216 citations

Opposing Activities of Dally-like Glypican at High and Low Levels of Wingless Morphogen Activity

2004 • 213 citations

Hedgehog signal transduction: recent findings

2002 • 183 citations

Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus

2000 • 180 citations

Cholesterol Modification of Hedgehog Is Required for Trafficking and Movement, Revealing an Asymmetric Cellular Response to Hedgehog

2003 • 180 citations

The endocytic pathway and formation of the Wingless morphogen gradient

2005 • 174 citations

Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements

2003 • 173 citations

Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog inDrosophilaepithelia

2006 • 148 citations

Glypicans shunt the Wingless signal between local signalling and further transport

2005 • 148 citations

Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix

2006 • 139 citations

The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels

1999 • 135 citations

The emergent design of the neural tube: prepattern, SHH morphogen and GLI code

2003 • 130 citations

The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors

2004 • 119 citations

Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation

2000 • 118 citations

Structure of a heparin-dependent complex of Hedgehog and Ihog

2006 • 90 citations

The Low Density Lipoprotein Receptor-related Protein Complexes with Cell Surface Heparan Sulfate Proteoglycans to Regulate Proteoglycan-mediated Lipoprotein Catabolism

2003 • 82 citations

Morphogen Transport along Epithelia, an Integrated Trafficking Problem

2002 • 82 citations

Cell surface heparan sulfate proteoglycans and lipoprotein metabolism

1999 • 76 citations

Release and trafficking of lipid-linked morphogens

2005 • 66 citations

Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog

2005 • 60 citations

Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytes.

2005 • 52 citations

Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused

2005 • 47 citations

The mechanism of hedgehog signal transduction

2005 • 40 citations

Regulation of Ci and Su(fu) nuclear import in Drosophila

2006 • 35 citations

The mechanism of hedgehog signal transduction

2005 • 31 citations

BMP Signalling: Synergy and Feedback Create a Step Gradient

2005 • 24 citations