Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

PC12 Pheochromocytoma Cultures in Neurobiological Research

1982 • 728 citations

Characterization and isolation of proteolytically modified nerve growth factor

1976 • 677 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription.

1986 • 548 citations

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

1990 • 529 citations

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

1985 • 458 citations

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1978 • 431 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro

1963 • 417 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Signal transmission by the insulin-like growth factors

1989 • 380 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells

1988 • 320 citations

Vasoactive intestinal peptide regulates mitosis, differentiation and survival of cultured sympathetic neuroblasts

1990 • 317 citations

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.

1988 • 312 citations

Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor

1987 • 297 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

1987 • 267 citations

Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor

1981 • 262 citations

The role of estrogens on the proliferation of human breast tumor cells (MCF-7)

1985 • 257 citations

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

1988 • 252 citations

Experimental autoimmune model of nerve growth factor deprivation: Effects on developing peripheral sympathetic and sensory neurons

1979 • 220 citations

Small intensely fluorescent cells in culture: role of glucocorticoids and growth factors in their development and interconversions with other neural crest derivatives

1985 • 206 citations

Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release

1987 • 204 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases.

1986 • 169 citations

Activated N‐ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells

1986 • 149 citations

Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not to adenosine agonists.

1985 • 113 citations

EFFECTS OF A NERVE‐GROWTH FACTOR, EMBRYO AGE AND METABOLIC INHIBITORS ON GROWTH OF FIBRES AND ON SYNTHESIS OF RIBONUCLEIC ACID AND PROTEIN IN EMBRYONIC SYMPATHETIC GANGLIA¹

1971 • 111 citations

Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro

1990 • 103 citations

The mode of action of nerve growth factor in PC12 cells

1988 • 102 citations

The Lack of a Role for Protein Kinase C in Neurite Extension and in the Induction of Ornithine Decarboxylase by Nerve Growth Factor in PC12 Cells

1989 • 78 citations

Dissociation of c-fos from ODC expression and neuronal differentiation in a PC12 subline stably transfected with an inducible N-ras oncogene

1988 • 70 citations

Tumor-promoting phorbol diester mimics two distinct neuronotrophic factors

1985 • 68 citations

Identification and Characterization of mRnas Regulated by Nerve Growth Factor in PC12 Cells

1987 • 67 citations

Both nerve growth factor and high K+ concentrations support the survival of chick embryo sympathetic neurons Evidence for a common mechanism of action

1983 • 61 citations

Insulin and Insulin-Like Growth Factors Stimulate Deoxyribonucleic Acid Synthesis in PC 12 Pheochromocytoma Cells

1988 • 60 citations

Death of serum-free mouse embryo cells caused by epidermal growth factor deprivation is prevented by cycloheximide, 12-O-tetradecanoylphorbol-13-acetate, or vanadate

1990 • 48 citations

Nerve growth factor action on membrane permeation to exogenous substrates in dorsal root ganglionic dissociates from the chick embryo

1977 • 40 citations

Insulin-like growth factors are mitogens for rat pheochromocytoma PC 12 cells

1988 • 33 citations

Multiple Pathways of N‐Kinase Activation in PC12 Cells

1990 • 31 citations

Intrinsic kinase activity of the insulin receptor

1990 • 29 citations

Characterization of Insulin-Like Growth Factor-I Receptors in PC 12 Pheochromocytoma Cells and Bovine Adrenal Medulla

1989 • 28 citations

Receptors for Insulin-Like Growth Factors in the Central Nervous System: Structure and Function

1988 • 26 citations