Activation of the Native 45-kDa Precursor Form of Interleukin-1-converting Enzyme

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

1984 • 1,042 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis

1996 • 327 citations

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases

1995 • 281 citations

Inactivation of Interleukin-1.beta. Converting Enzyme by Peptide (Acyloxy)methyl Ketones

1994 • 267 citations

Activation of interleukin‐ 1β by a co‐induced protease

1989 • 254 citations

[43] Interleukin-1β converting enzyme

1994 • 208 citations

Cloning and Expression of Four Novel Isoforms of Human Interleukin-1β Converting Enzyme with Different Apoptotic Activities

1995 • 149 citations

IL-1 beta-converting enzyme is present in monocytic cells as an inactive 45-kDa precursor.

1994 • 113 citations

Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells.

1993 • 111 citations

Expression, Refolding, and Autocatalytic Proteolytic Processing of the Interleukin-1β-converting Enzyme Precursor

1995 • 107 citations

Amino acid sequence analysis of human interleukin 1 (IL-1). Evidence for biochemically distinct forms of IL-1.

1985 • 86 citations

The Structure and Complete Nucleotide Sequence of the Murine Gene Encoding Interleukin-1β Converting Enzyme (ICE)

1994 • 62 citations

Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1 beta converting enzyme.

1995 • 52 citations

Molecular Characterization of the Gene for Human Interleukin-1β Converting Enzyme (IL1BC)

1994 • 45 citations

A Synthetic Inhibitor of Interleukin-lβ Converting Enzyme Prevents Endotoxin-Induced Interleukin-lβ ProductionIn VitroandIn Vivo

1995 • 41 citations

Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA.

1995 • 30 citations