Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2.

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Growth of factor-dependent hemopoietic precursor cell lines.

1980 • 793 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment

1986 • 536 citations

Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene

1993 • 495 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line.

1982 • 227 citations

Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.

1989 • 216 citations

In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1.

1992 • 190 citations

DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels.

1990 • 185 citations

c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock.

1988 • 154 citations

c-myc and c-fos expression in differentiating mouse primary keratinocytes.

1986 • 130 citations

The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle.

1992 • 113 citations

Myc-Mediated Apoptosis Is Blocked by Ectopic Expression of Bcl-2

1993 • 57 citations

Genome Digestion Is a Dispensable Consequence of Physiological Cell Death Mediated by Cytotoxic Τ Lymphocytes

1992 • 51 citations

Cloning and sequencing of a sheep metallothionein cDNA

1984 • 21 citations