Purification of an Interleukin-1β Converting Enzyme-related Cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between the Leucine Zipper and Transmembrane Domains

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

1993 • 906 citations

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

1993 • 593 citations

The interplay of DNA-binding proteins on the promoter of the mouse albumin gene

1987 • 532 citations

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence

1993 • 396 citations

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

1995 • 305 citations

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization

1993 • 300 citations

Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product

1992 • 296 citations

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

1995 • 291 citations

Internal protein sequence analysis: Enzymatic digestion for less than 10 μg of protein bound to polyvinylidene difluoride or nitrocellulose membranes

1992 • 290 citations

Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).

1994 • 199 citations

The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.

1992 • 187 citations

Interleukin‐1βconverting enzyme: A novel cysteine protease required for IL‐1β production and implicated in programmed cell death

1995 • 170 citations

cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper

1989 • 154 citations

IL-1 beta-converting enzyme is present in monocytic cells as an inactive 45-kDa precursor.

1994 • 113 citations

Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.

1994 • 105 citations

Preparation of protected amino aldehydes

1981 • 58 citations