Apoptosis induced by anticancer drugs

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

1988 • 1,174 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

1990 • 887 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

1992 • 542 citations

Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.

1990 • 489 citations

Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation.

1990 • 485 citations

2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca ²⁺ -Mediated Endonuclease Activation

1988 • 460 citations

Analysis of Events Associated With Cell Cycle Arrest at G2 Phase and Cell Death Induced by Cisplatin

1990 • 447 citations

Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation.

1991 • 429 citations

Inflammation and Oxidative Stress in Carcinogenesis

1993 • 419 citations

Drug-target interactions: only the first step in the commitment to a programmed cell death?

1991 • 412 citations

Activation of programmed cell death by anticancer agents: cisplatin as a model system.

1990 • 408 citations

Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.

1991 • 392 citations

Cascade Induction of c-fos, c-myc, and Heat Shock 70K Transcripts during Regression of the Rat Ventral Prostate Gland

1988 • 355 citations

Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

1990 • 319 citations

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B.

1991 • 301 citations

An electron‐microscope study of the mode of cell death induced by cancer‐chemotherapeutic agents in populations of proliferating normal and neoplastic cells

1975 • 300 citations

Mechanism by which caffeine potentiates lethality of nitrogen mustard.

1982 • 294 citations

Isolation and characterization of Schizosaccharomyces pombe cut mutants that block nuclear division but not cytokinesis

1986 • 292 citations

Inhibition of DNA Fragmentation in Thymocytes and Isolated Thymocyte Nuclei by Agents That Stimulate Protein Kinase C

1989 • 276 citations

Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action

1989 • 254 citations

Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.

1987 • 251 citations

Influence of cis-diamminedichloroplatinum(II) on DNA synthesis and cell cycle progression in excision repair proficient and deficient Chinese hamster ovary cells.

1988 • 226 citations

Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells.

1990 • 222 citations

Rapidin VivoEffects of Glucocorticoids on the Integrity of Rat Lymphocyte Genomic Deoxyribonucleic Acid*

1986 • 218 citations

Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells.

1990 • 216 citations

Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.

1989 • 216 citations

Antiinflammatory steroid action: Basic and clinical aspects

1990 • 202 citations

Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine.

1991 • 198 citations

Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells

1976 • 197 citations

Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias.

1992 • 188 citations

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1984 • 188 citations

Rodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression

1987 • 179 citations

Steroid receptor-mediated cytotoxicity of an antiestrogen and an antiprogestin in breast cancer cells.

1987 • 172 citations

Identification of a glucocorticoid-induced nuclease in thymocytes. A potential “lysis gene” product.

1987 • 167 citations

Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines.

1991 • 165 citations

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.

1991 • 165 citations

Rescue from programmed cell death in leukemic and normal myeloid cells

1991 • 165 citations

Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.

1991 • 163 citations

Endogenous nuclease. Properties and effects on transcribed genes in chromatin.

1982 • 159 citations

IL-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death.

1989 • 158 citations

Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis.

1991 • 157 citations

Cytotoxic effects of cell cycle phase specific agents: result of cell cycle perturbation.

1990 • 144 citations

Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression.

1991 • 137 citations

Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).

1990 • 134 citations

The calcium dependent endonuclease activity of isolated nuclear preparations. Relationships between its occurrence and the occurrence of other classes of enzymes found in nuclear preparations

1973 • 127 citations

Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells.

1991 • 109 citations

Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis.

1992 • 106 citations

Glucocorticoid Effect on Oncogene/Growth Gene Expression in Human T Lymphoblastic Leukemic Cell Line CCRF-CEM

1989 • 101 citations

Isolation and Characterization of Glucocorticoid- and Cyclic AMP-Induced Genes in T Lymphocytes

1989 • 95 citations

Glucocorticoid-induced Lymphocytolysis Is Not Mediated by an Induced Endonuclease

1989 • 94 citations

Glucocorticoid-resistant human acute lymphoblastic leukemic cell line with functional receptor.

1983 • 93 citations

Genes Newly Identified as Regulated by Glucocorticoids in Murine Thymocytes

1991 • 91 citations

Cell death induced by topoisomerase inhibitors

1991 • 89 citations

Effects of cycloheximide on B-chronic lymphocytic leukaemic and normal lymphocytes in vitro: induction of apoptosis

1991 • 87 citations

Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard.

1991 • 85 citations

Glucocorticoid inhibition of c-myc, c-myb, and c-Ki-ras expression in a mouse lymphoma cell line.

1986 • 82 citations

Resistance to Antineoplastic Drugs

1990 • 81 citations

Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid.

1988 • 81 citations

Kinetic and Physical Studies of Cell Death Induced By Chemotherapeutic Agents Or Hyperthermia

1986 • 79 citations

Inhibition of both etoposide-induced DNA fragmentation and activation of poly(ADP-ribose) synthesis by zinc ion

1990 • 78 citations

Thymocyte apoptosis a model of programmed cell death

1992 • 76 citations

Activation of the c-jun protooncogene in human myeloid leukemia cells treated with etoposide.

1991 • 74 citations

Activation of Programmed Cell Death by Recombinant Human Tumor Necrosis Factor Plus Topoisomerase II - Targeted Drugs in L929 Tumor Cells

1991 • 70 citations

Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukaemia cells

1992 • 65 citations

Isolation and characterization of glucocorticoid- and cyclic AMP-induced genes in T lymphocytes.

1989 • 64 citations

The protooncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism.

1991 • 64 citations

Internucleosomal Deoxyribonucleic Acid Cleavage Activity in Apoptotic Thymocytes: Detection and Endocrine Regulation*

1991 • 61 citations

Isolation of a cDNA clone, encoding a human β-galactoside binding protein, overexpressed during glucocorticoid-induced cell death

1991 • 60 citations

Does bulk damage to DNA explain the cytostatic and cytotoxic effects of topoisomerase II inhibitors?

1991 • 56 citations

Resistance to antineoplastic drugs

1989 • 53 citations

Topoisomerase inhibitors induce irreversible fragmentation of replicated DNA in concanavalin A stimulated splenocytes

1988 • 50 citations

Mapping the human glucocorticoid receptor for leukemic cell death

1991 • 48 citations

Progressive formation of DNA lesions in cultured Ehrlich ascites tumor cells treated with hydroxyurea.

1987 • 48 citations

Dexamethasone‐induced killing of neoplastic cells of lymphoid derivation: Lack of early calcium involvement

1990 • 47 citations

Molecular changes associated with induction of cell death in a human T-cell leukaemia line: Putative nucleases identified as histones

1989 • 46 citations

Topoisomerase II as a target of antileukemia drugs: a review of controversial areas.

1989 • 44 citations

Glucocorticoid-Induced Cell Death and Poly[Adenosine Diphosphate(ADP)-Ribosyl]ation: Increased Toxicity of Dexamethasone on Mouse S49.1 Lymphoma Cells with the Poly(ADP-Ribosyl)ation Inhibitor Benzamide*

1986 • 37 citations

Mitochondrial phosphate transport. Import of the H+/Pi symporter and role of the presequence.

1991 • 36 citations

Complementation between glucocorticoid receptor and lymphocytolysis in somatic cell hybrids of two glucocorticoid-resistant human leukemic clonal cell lines

1987 • 31 citations

Role of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid-induced cytotoxicity in susceptible lymphoid cells.

1987 • 31 citations

N-(5,5-diacetoxypentyl)doxorubicin: a novel anthracycline producing DNA interstrand cross-linking and rapid endonucleolytic cleavage in human leukemia cells.

1991 • 29 citations

Inherent sensitivity and induced resistance to chemotherapeutic drugs and irradiation in human cancer cell lines: relationship to mutation frequencies.

1990 • 27 citations

Novobiocin induces the in vivo cleavage of active gene sequences in intact cells.

1986 • 24 citations

Influence of cis-dichlorodiammineplatinum on the structure of the immature rat cerebellum

1986 • 24 citations

DNA repair in human promyelocytic cell line, HL-60

1987 • 21 citations

Transcriptional Transactivation Functions Localized to the Glucocorticoid Receptor N Terminus Are Necessary for Steroid Induction of Lymphocyte Apoptosis

1992 • 21 citations

Possible role of cholesterol in the susceptibility of a human acute lymphoblastic leukemia cell line to dexamethasone.

1986 • 18 citations

Insensitivity to the cytolytic effects of glucocorticoids in vivo is associated with a novel "slow death" phenotype.

1991 • 16 citations

Glucocorticoid insensitivity of P1798 lymphoma cells is associated with production of a factor that attenuates the lytic response.

1991 • 15 citations

Ultrastructural cytochemistry of cis-dichlorodiammine platinum II induced apoptosis in immature rat cerebellum.

1990 • 15 citations

The role of cholesterol in the glucocorticoid-mediated inhibition of cell cycle progression in human acute lymphoblastic leukemia cells

1987 • 14 citations

Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone

1989 • 8 citations

Inhibition of 2-desamino-2-methyl-10-propagyl-5,8-dideazafolic acid cytotoxicity by 5,10-dideazatetrahydrofolate in L1210 cells with decrease in DNA fragmentation and deoxyadenosine triphosphate pools

1991 • 8 citations

Corticosteroid effects on lipid lateral diffusion in CEM-C1 and CEM-C7 acute lymphoblastic leukemia cells

1991 • 5 citations

Stat Bite Oncologists Experience Burnout

1991 • 1 citations

Deleted Work

1955 • 0 citations