Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

STATs and Gene Regulation

1997 • 3,927 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

1998 • 1,155 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

Going the Distance: A Current View of Enhancer Action

1998 • 820 citations

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

1997 • 810 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Three-dimensional structure of the Stat3β homodimer bound to DNA

1998 • 769 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA

1998 • 696 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

1997 • 612 citations

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

1994 • 599 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

1994 • 506 citations

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

1996 • 501 citations

P210 and P190 Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members

1996 • 498 citations

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid Leukemia

1997 • 494 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Mutations in the Gene for the Granulocyte Colony-Stimulating–Factor Receptor in Patients with Acute Myeloid Leukemia Preceded by Severe Congenital Neutropenia

1995 • 471 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300

1997 • 428 citations

GAS Elements: A Few Nucleotides with a Major Impact on Cytokine-Induced Gene Expression

1997 • 428 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

1991 • 407 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

1995 • 363 citations

Activation of receptor-associated tyrosine kinase JAK2 by prolactin.

1994 • 354 citations

A sensitive method for the determination of protein-DNA binding specificities

1990 • 346 citations

Activation of Jak2 Catalytic Activity Requires Phosphorylation of Y¹⁰⁰⁷ in the Kinase Activation Loop

1997 • 343 citations

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

1999 • 341 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity

1998 • 323 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

Regulation of STAT‐dependent pathways by growth factors and cytokines

1996 • 297 citations

The hematopoietin receptor superfamily

1993 • 296 citations

Direct Association with and Dephosphorylation of Jak2 Kinase by the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-1

1996 • 291 citations

The Structure, Regulation and Function of the Janus Kinases (JAKs) and the Signal Transducers and Activators of Transcription (STATs)

1997 • 285 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

1999 • 283 citations

Role of STAT2 in the Alpha Interferon Signaling Pathway

1995 • 280 citations

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

1996 • 276 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

Interferon- Activates Multiple STAT Proteins and Upregulates Proliferation-Associated IL-2R, c-myc, and pim-1 Genes in Human T Cells

1999 • 273 citations

Erythropoietin Induces Activation of Stat5 through Association with Specific Tyrosines on the Receptor That Are Not Required for a Mitogenic Response

1996 • 272 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

STAT3 as an Adapter to Couple Phosphatidylinositol 3-Kinase to the IFNAR1 Chain of the Type I Interferon Receptor

1997 • 263 citations

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1998 • 261 citations

JAK/STAT signaling by cytokine receptors

1998 • 242 citations

A receptor for interleukin 10 is related to interferon receptors.

1993 • 233 citations

An Integrated Model of the Transcription Complex in Elongation, Termination, and Editing

1998 • 233 citations

SH2 Signaling in a Lower Eukaryote: A STAT Protein That Regulates Stalk Cell Differentiation in Dictyostelium

1997 • 230 citations

Aromatase P450 Gene Expression in Human Adipose Tissue. ROLE OF A Jak/STAT PATHWAY IN REGULATION OF THE ADIPOSE-SPECIFIC PROMOTER

1995 • 229 citations

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.

1996 • 228 citations

Transcriptional Activation of the p21 Gene by Interleukin-6 Type Cytokines

1998 • 227 citations

Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases

1998 • 227 citations

Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.

1996 • 224 citations

Identification and purification of human stat proteins activated in response to interleukin-2

1995 • 223 citations

Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation

1998 • 220 citations

Dependence on the Motif YIPP for the Physical Association of Jak2 Kinase with the Intracellular Carboxyl Tail of the Angiotensin II AT1 Receptor

1997 • 218 citations

Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

1995 • 218 citations

A JAK1/JAK2 Chimera Can Sustain Alpha and Gamma Interferon Responses

1997 • 216 citations

A Short Isoform of the Human Growth Hormone Receptor Functions as a Dominant Negative Inhibitor of the Full-Length Receptor and Generates Large Amounts of Binding Protein

1997 • 215 citations

The Significance of Tetramerization in Promoter Recruitment by Stat5

1999 • 213 citations

Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection

1999 • 210 citations

Cloning of Human Stat5B

1996 • 210 citations

Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.

1996 • 206 citations

Interaction of Growth Hormone-activated STATs with SH2-containing Phosphotyrosine Phosphatase SHP-1 and Nuclear JAK2 Tyrosine Kinase

1997 • 205 citations

Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

1996 • 204 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

1996 • 198 citations

Distribution of the Mammalian Stat Gene Family in Mouse Chromosomes

1995 • 195 citations

Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation

1998 • 193 citations

Thrombopoietin-Induced Differentiation of a Human Megakaryoblastic Leukemia Cell Line, CMK, Involves Transcriptional Activation of p21^WAF1/Cip1 by STAT5

1997 • 189 citations

Specific DNA Binding of Stat5, but Not of Glucocorticoid Receptor, Is Required for Their Functional Cooperation in the Regulation of Gene Transcription

1997 • 184 citations

A Single Tyrosine of the Interleukin-9 (IL-9) Receptor Is Required for STAT Activation, Antiapoptotic Activity, and Growth Regulation by IL-9

1996 • 182 citations

Preassociation of STAT1 with STAT2 and STAT3 in Separate Signalling Complexes Prior to Cytokine Stimulation

1996 • 182 citations

STAT5A-Deficient Mice Demonstrate a Defect in Granulocyte-Macrophage Colony-Stimulating Factor–Induced Proliferation and Gene Expression

1997 • 180 citations

Activation of Different Stat5 Isoforms Contributes to Cell-Type-Restricted Signaling in Response to Interferons

1996 • 176 citations

Transcription Factors Stat3 and Stat5b Are Present in Rat Liver Nuclei Late in an Acute Phase Response and Bind Interleukin-6 Response Elements

1995 • 174 citations

Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway

1998 • 174 citations

Prolactin Signaling in Mammary Gland Development

1997 • 174 citations

Studies of IFN-Induced Transcriptional Activation Uncover the Jak-Stat Pathway

1998 • 173 citations

Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580

1996 • 171 citations

IL‐10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes

1996 • 170 citations

The interferon gamma (IFN-γ) receptor: a paradigm for the multichain cytokine receptor

1997 • 169 citations

Function of Stat2 Protein in Transcriptional Activation by Alpha Interferon

1996 • 169 citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1996 • 167 citations

Induction of Jak/STAT Signaling by Activation of the Type 1 TNF Receptor

1998 • 166 citations

STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin

1996 • 165 citations

Granulocyte-Macrophage Colony-stimulating Factor-activated Signaling Pathways in Human Neutrophils

1998 • 165 citations

Characterization of Stat5a and Stat5b Homodimers and Heterodimers and Their Association with the Glucocortiocoid Receptor in Mammary Cells

1998 • 164 citations

A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B

1998 • 160 citations

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

1995 • 160 citations

The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein

1996 • 159 citations

Dissecting the thrombopoietin receptor: Functional elements of the Mpl cytoplasmic domain

1997 • 158 citations

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT

1997 • 158 citations

Signaling from the IL-2 receptor to the nucleus

1997 • 157 citations

Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes

1996 • 156 citations

Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase

1997 • 155 citations

Functionally Distinct Isoforms of STAT5 Are Generated by Protein Processing

1997 • 155 citations

Stat5 as a Target for Regulation by Extracellular Matrix

1995 • 154 citations

A Small, Nonpeptidyl Mimic of Granulocyte-Colony- Stimulating Factor

1998 • 153 citations

Distinctive Roles of STAT5a and STAT5b in Sexual Dimorphism of Hepatic P450 Gene Expression

1999 • 152 citations

Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response

1999 • 150 citations

Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells

1998 • 143 citations

STAT3 Is a Serine Kinase Target in T Lymphocytes

1997 • 139 citations

STAT5 Interaction with the T Cell Receptor Complex and Stimulation of T Cell Proliferation

1999 • 132 citations

Signaling via IL-2 and IL-4 in JAK3-Deficient Severe Combined Immunodeficiency Lymphocytes: JAK3-Dependent and Independent Pathways

1996 • 129 citations

Regulation of Signal Transducer and Activator of Transcription (STAT) 5b Activation by the Temporal Pattern of Growth Hormone Stimulation

1997 • 129 citations

JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization.

1994 • 127 citations

Comparison of the Transactivation Domains of Stat5 and Stat6 in Lymphoid Cells and Mammary Epithelial Cells

1997 • 126 citations

Activation of a CrkL-Stat5 Signaling Complex by Type I Interferons

1999 • 126 citations

Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor.

1996 • 126 citations

Participation of JAK and STAT Proteins in Growth Hormone-induced Signaling

1996 • 124 citations

Promoter-dependent Synergy between Glucocorticoid Receptor and Stat5 in the Activation of β-Casein Gene Transcription

1997 • 123 citations

Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL

1997 • 123 citations

Glucocorticoid Receptor/Signal Transducer and Activator of Transcription 5 (STAT5) Interactions Enhance STAT5 Activation by Prolonging STAT5 DNA Binding and Tyrosine Phosphorylation

1999 • 123 citations

Erythropoietin Induces the Tyrosine Phosphorylation, Nuclear Translocation, and DNA Binding of STAT1 and STAT5 in Erythroid Cells

1995 • 122 citations

Stat5 is a physiological substrate of the insulin receptor

1997 • 122 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH

1996 • 122 citations

Mutational Analysis of Acute-Phase Response Factor/Stat3 Activation and Dimerization

1997 • 121 citations

Regulation of mammary gland factor/Stat5a during mammary gland development.

1995 • 119 citations

Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two γ-Activated Sites

1995 • 118 citations

Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity

1997 • 118 citations

Signaling of Type II Oncostatin M Receptor

1997 • 117 citations

Interferon gamma rapidly induces in human monocytes a DNA-binding factor that recognizes the gamma response region within the promoter of the gene for the high-affinity Fc gamma receptor.

1992 • 114 citations

The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cδ

1997 • 112 citations

A nuclear tyrosine phosphatase downregulates interferon-induced gene expression.

1993 • 112 citations

Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.

1997 • 111 citations

Interleukin 5 and B cell differentiation

1998 • 110 citations

Beta Interferon and Oncostatin M Activate Raf-1 and Mitogen-Activated Protein Kinase through a JAK1-Dependent Pathway

1997 • 109 citations

A proliferation switch for genetically modified cells

1997 • 108 citations

Lactogenic Hormone Activation of Stat5 and Transcription of the β-Casein Gene in Mammary Epithelial Cells Is Independent of p42 ERK2 Mitogen-activated Protein Kinase Activity

1996 • 108 citations

Abrogation of Interleukin-3 Dependence of Myeloid Cells by the v-src Oncogene Requires SH2 and SH3 Domains Which Specify Activation of STATs

1997 • 108 citations

Involvement of SHC, GRB2, SOS and RAS in prolactin signal transduction in mammary epithelial cells.

1996 • 105 citations

Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless.

1995 • 105 citations

Interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 transduce signals through two forms of STAT5

1995 • 105 citations

Extracellular Signal-Regulated Kinase (ERK) Interacts with Signal Transducer and Activator of Transcription (STAT) 5a

1999 • 104 citations

Jaks and stats in cytokine signaling

1997 • 104 citations

Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5.

1997 • 101 citations

Box 3-independent Signaling Mechanisms Are Involved in Leukemia Inhibitory Factor Receptor α- and gp130-mediated Stimulation of Mitogen-activated Protein Kinase

1997 • 101 citations

JAK2 and JAK1 Constitutively Associate With an Interleukin-5 (IL-5) Receptor α and βc Subunit, Respectively, and Are Activated Upon IL-5 Stimulation

1998 • 99 citations

Erythropoietin-Induced Activation of STAT5 Is Impaired in the Myelodysplastic Syndrome

1997 • 98 citations

Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation

1997 • 98 citations

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

1997 • 97 citations

Prolactin signal transduction mechanisms in the mammary gland: the role of the Jak/Stat pathway

1996 • 97 citations

Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases

1998 • 97 citations

Reflections on STAT3, STAT5, and STAT6 as fat STATs.

1996 • 96 citations

Stimulation of Stat5 by Granulocyte Colony-Stimulating Factor (G-CSF) Is Modulated by Two Distinct Cytoplasmic Regions of the G-CSF Receptor

1998 • 96 citations

Leptin and OB-R: Body weight regulation by a cytokine receptor

1996 • 95 citations

Regulation of Interferon-α Responsiveness by the Duration of Janus Kinase Activity

1997 • 94 citations

Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity.

1995 • 93 citations

Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes

1996 • 93 citations

Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene.

1996 • 92 citations

Transcriptional Inhibition by Stat5

1997 • 92 citations

Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor β-chain

1995 • 92 citations

A Single Tyrosine Residue in the Membrane-proximal Domain of the Granulocyte-Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptor Common β-Chain Is Necessary and Sufficient for High Affinity Binding and Signaling by All Three Ligands

1996 • 92 citations

STAT5 Activation Correlates with Erythropoietin Receptor-mediated Erythroid Differentiation of an Erythroleukemia Cell Line

1997 • 90 citations

A Single Amino Acid in the DNA Binding Regions of STAT5A and STAT5B Confers Distinct DNA Binding Specificities

1998 • 88 citations

Carboxyl-Truncated STAT5β Is Generated by a Nucleus-Associated Serine Protease in Early Hematopoietic Progenitors

1998 • 87 citations

Prolactin Stimulates Serine/Tyrosine Phosphorylation and Formation of Heterocomplexes of Multiple Stat5 Isoforms in Nb2 Lymphocytes

1997 • 86 citations

Interaction of STAT5 Dimers on Two Low Affinity Binding Sites Mediates Interleukin 2 (IL-2) Stimulation of IL-2 Receptor α Gene Transcription

1997 • 86 citations

An Epidermal Growth Factor Receptor/Jak2 Tyrosine Kinase Domain Chimera Induces Tyrosine Phosphorylation of Stat5 and Transduces a Growth Signal in Hematopoietic Cells

1996 • 85 citations

Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF β-receptor juxtamembrane and kinase insert domains

1998 • 85 citations

Grb10 Identified as a Potential Regulator of Growth Hormone (GH) Signaling by Cloning of GH Receptor Target Proteins

1998 • 84 citations

The Interleukin-4 Receptor Activates STAT5 by a Mechanism That Relies upon Common γ-Chain

1998 • 83 citations

Erythropoietin Induces Tyrosine Phosphorylation of Jak2, STAT5A, and STAT5B in Primary Cultured Human Erythroid Precursors

1998 • 83 citations

Mapping of a Cytoplasmic Domain of the Human Growth Hormone Receptor That Regulates Rates of Inactivation of Jak2 and Stat Proteins

1997 • 80 citations

Tyrosine Residues in the Granulocyte Colony-stimulating Factor (G-CSF) Receptor Mediate G-CSF-induced Differentiation of Murine Myeloid Leukemic (M1) Cells

1996 • 80 citations

A Functional DNA Binding Domain Is Required for Growth Hormone-induced Nuclear Accumulation of Stat5B

1999 • 79 citations

Activation of the Jak2-Stat5 Signaling Pathway in Nb2 Lymphoma Cells by an Anti-apoptotic Agent, Aurintricarboxylic Acid

1998 • 79 citations

Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo.

1996 • 76 citations

STAT3 and STAT5B Are Targets of Two Different Signal Pathways Activated by Hematopoietin Receptors and Control Transcription via Separate Cytokine Response Elements

1995 • 76 citations

The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor

1997 • 75 citations

Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b.

1998 • 74 citations

Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.

1998 • 74 citations

Critical proline residues of the cytoplasmic domain of the IL-5 receptor α chain and its function in IL-5-mediated activation of JAK kinase and STAT5

1996 • 74 citations

Prolactin Receptor Regulates Stat5 Tyrosine Phosphorylation and Nuclear Translocation by Two Separate Pathways

1998 • 74 citations

Interleukin-3–Induced Activation of the JAK/STAT Pathway Is Prolonged by Proteasome Inhibitors

1998 • 73 citations

Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain.

1996 • 72 citations

Interferonγ Activation of Raf-1 Is Jak1-dependent and p21ras-independent

1998 • 72 citations

Growth Hormone-Induced Tyrosyl Phosphorylation and Deoxyribonucleic Acid Binding Activity of Stat5A and Stat5B*

1997 • 71 citations

Cytokines: Shared receptors, distinct functions

1997 • 71 citations

A Distinct Function of STAT Proteins in Erythropoietin Signal Transduction

1997 • 69 citations

Conformational Changes Required in the Human Growth Hormone Receptor for Growth Hormone Signaling

1997 • 67 citations

The box1 Domain of the Erythropoietin Receptor Specifies Janus Kinase 2 Activation and Functions Mitogenically within an Interleukin 2 β-Receptor Chimera

1996 • 67 citations

Binding of STAT5a and STAT5b to a Single Element Resembling a γ-Interferon-Activated Sequence Mediates the Growth Hormone Induction of the Mouse Acid-Labile Subunit Promoter in Liver Cells

1998 • 67 citations

The JAK-STAT pathway in Drosophila

1997 • 65 citations

Angiotensin II Activates Stat5 Through Jak2 Kinase in Cardiac Myocytes

1998 • 65 citations

A STAT Factor Mediates the Sexually Dimorphic Regulation of Hepatic Cytochrome P450 3A10/Lithocholic Acid 6β-Hydroxylase Gene Expression by Growth Hormone

1995 • 65 citations

Mammary gland factor activated by prolactin on mammary epithelial cells and acute-phase response factor activated by interleukin-6 in liver cells share DNA binding and transactivation potential.

1994 • 65 citations

Signal Transducer and Activator of Transcription-3 Serine Phosphorylation by Insulin Is Mediated by a Ras/Raf/MEK-Dependent Pathway*

1997 • 64 citations

Influence of Subunit Combinations on Signaling by Receptors for Oncostatin M, Leukemia Inhibitory Factor, and Interleukin-6

1997 • 64 citations

Cutting Edge: Involvement of SHP-2 in Multiple Aspects of IL-2 Signaling: Evidence for a Positive Regulatory Role

1998 • 63 citations

Prolactin induction of the alpha 2-Macroglobulin gene in rat ovarian granulosa cells: stat 5 activation and binding to the interleukin-6 response element.

1996 • 62 citations

Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor

1996 • 62 citations

Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene

1996 • 62 citations

Transcriptional Activation of the IL-6 Response Element in the junB Promoter Is Mediated by Multiple Stat Family Proteins

1994 • 62 citations

A Short Isoform of the Human Growth Hormone Receptor Functions as a Dominant Negative Inhibitor of the Full-Length Receptor and Generates Large Amounts of Binding Protein

1997 • 62 citations

Two Discrete Regions of Interleukin-2 (IL2) Receptor β Independently Mediate IL2 Activation of a PD98059/Rapamycin/Wortmannin-insensitive Stat5a/b Serine Kinase

1997 • 62 citations

Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5

1997 • 61 citations

Roles of the N and C Terminal Domains of the Interleukin-3 Receptor α Chain in Receptor Function

1997 • 60 citations

Growth Hormone Promotes the Association of Transcription Factor STAT5 with the Growth Hormone Receptor

1996 • 60 citations

Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-γ and interleukin-4 receptor-α

1996 • 59 citations

The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2

1995 • 58 citations

Role of Cytokine Signaling Molecules in Erythroid Differentiation of Mouse Fetal Liver Hematopoietic Cells: Functional Analysis of Signaling Molecules by Retrovirus-Mediated Expression

1999 • 58 citations

Dominant Negative Variants of the SHP-2 Tyrosine Phosphatase Inhibit Prolactin Activation of Jak2 (Janus Kinase 2) and Induction of Stat5 (Signal Transducer and Activator of Transcription 5)-Dependent Transcription

1998 • 58 citations

Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells

1998 • 57 citations

HIV-1 infection induces a selective reduction in STAT5 protein expression.

1998 • 57 citations

Prolactin signal transduction to milk protein genes: carboxy-terminal part of the prolactin receptor and its tyrosine phosphorylation are not obligatory for JAK2 and STAT5 activation

1997 • 56 citations

Immunocompromised tumor-bearing mice show a selective loss of STAT5a/b expression in T and B lymphocytes.

1997 • 54 citations

Design of Conditionally Active STATs: Insights into STAT Activation and Gene Regulatory Function

1999 • 53 citations

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation

1996 • 53 citations

Role of the STAT1-SH2 Domain and STAT2 in the Activation and Nuclear Translocation of STAT1

1998 • 52 citations

The CIS/JAB family: novel negative regulators of JAK signaling pathways

1998 • 51 citations

Mechanism of Interaction between the Glucocorticoid Receptor and Stat5: Role of DNA-Binding

1997 • 51 citations

New insights into heparin-induced FGF oligomerization

1998 • 50 citations

Cytokines and their receptor complexes

1995 • 50 citations

Jak2-Stat5 Interactions Analyzed in Yeast

1998 • 50 citations

Mitogenic Signaling and Inhibition of Apoptosis via the Erythropoietin Receptor Box-1 Domain

1997 • 49 citations

Antigen-receptor engagement in B cells induces nuclear expression of STAT5 and STAT6 proteins that bind and transactivate an IFN-gamma activation site.

1996 • 48 citations

Cutting Edge: HIV-1 Infection Induces a Selective Reduction in STAT5 Protein Expression

1998 • 48 citations

Composite response elements mediate hormonal and developmental regulation of milk protein gene expression.

1998 • 47 citations

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor γ _c chain for Janus kinase activation leading to T cell proliferation

1997 • 47 citations

Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency.

1997 • 47 citations

Differential Activation of Functionally Distinct STAT5 Proteins by IL‐5 and GM‐CSF During Eosinophil and Neutrophil Differentiation from Human CD34 ⁺ Hematopoietic Stem Cells

1998 • 47 citations

Characterization of the Role of the Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Subunit in the Activation of JAK2 and STAT5

1998 • 46 citations

Regulation of mammary gland factor/Stat5a during mammary gland development

1995 • 46 citations

JAK2 and STAT5, but not JAK1 and STAT1, Are Required for Prolactin-Induced β-Lactoglobulin Transcription

1997 • 45 citations

Stoichiometric Structure-Function Analysis of the Prolactin Receptor Signaling Domain by Receptor Chimeras

1998 • 44 citations

Granulocyte‐macrophage colony‐stimulating factor induces a unique set of STAT factors in murine dendritic cells

1997 • 42 citations

cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2→q32.3

1997 • 41 citations

STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase

1998 • 40 citations

Prolonged STAT1 Activation Related to the Growth Arrest of Malignant Lymphoma Cells by Interferon-α

1998 • 40 citations

Signalling by the oncogenic receptor tyrosine kinase Xmrk leads to activation of STAT5 in Xiphophorus melanoma

1998 • 40 citations

Cytokine Receptor-independent, Constitutively Active Variants of STAT5

1997 • 39 citations

Activation and Functional Analysis of Janus Kinase 2 in BA/F3 Cells Using the Coumermycin/Gyrase B System

1998 • 39 citations

Proteasome- and p53-dependent Masking of Signal Transducer and Activator of Transcription (STAT) Factors

1997 • 37 citations

Insulin-like Growth Factor-I Augments Erythropoietin-induced Proliferation through Enhanced Tyrosine Phosphorylation of STAT5

1998 • 36 citations

JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization

1994 • 36 citations

Erythropoietin Induces Tyrosine Phosphorylation of the Interleukin-3 Receptor β Subunit (βIL3 ) and Recruitment of Stat5 to Possible Stat5-Docking Sites in βIL3

1997 • 36 citations

IL-2 and IL-7 Induce Heterodimerization of STAT5 Isoforms in Human Peripheral Blood T Lymphoblasts

1997 • 35 citations

Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation.

1998 • 34 citations

TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28

1998 • 33 citations

Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless

1995 • 32 citations

Prolactin activates Stat1 but does not antagonize Stat1 activation and growth inhibition by type I interferons in human breast cancer cells.

1998 • 32 citations

Transcriptional Regulation of the β-Casein Gene by Cytokines: Cross-Talk between STAT5 and Other Signaling Molecules

1998 • 32 citations

Regulation of the erythropoietin receptor and involvement of JAK2 in differentiation of J2E erythroid cells.

1996 • 31 citations

Regulation of Signal Transducer and Activator of Transcription (STAT) 5b Activation by the Temporal Pattern of Growth Hormone Stimulation

1997 • 31 citations

Identification of an additional isoform of STAT5 expressed in immature macrophages.

1998 • 29 citations

Glucocorticoid Receptor/Signal Transducer and Activator of Transcription 5 (STAT5) Interactions Enhance STAT5 Activation by Prolonging STAT5 DNA Binding and Tyrosine Phosphorylation

1999 • 29 citations

Erythropoietin and Friend Virus gp55 Activate Different JAK/STAT Pathways through the Erythropoietin Receptor in Erythroid Cells

1998 • 29 citations

Thrombopoietin Induces Association of Crkl With STAT5 But Not STAT3 in Human Platelets

1998 • 29 citations

The house that JAK/STAT built

1997 • 28 citations

Requirement for Distinct Janus Kinases and STAT Proteins in T Cell Proliferation Versus IFN-γ Production Following IL-12 Stimulation

1998 • 28 citations

Receptors That Induce Erythroid Differentiation of Ba/F3 Cells: Structural Requirements and Effect on STAT5 Binding

1997 • 28 citations

Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo

1996 • 27 citations

Selective coupling of STAT factors to the mouse prolactin receptor

1998 • 27 citations

Multiple tyrosine residues in the intracellular domain of the common β subunit of the interleukin 5 receptor are involved in activation of STAT5

1997 • 26 citations

Association of CrkL with STAT5 in Hematopoietic Cells Stimulated by Granulocyte–Macrophage Colony-Stimulating Factor or Erythropoietin

1998 • 25 citations

Extracellular Signal-Regulated Kinase (ERK) Interacts with Signal Transducer and Activator of Transcription (STAT) 5a

1999 • 25 citations

Cutting Edge: Identification of an Additional Isoform of STAT5 Expressed in Immature Macrophages

1998 • 25 citations

Studies of the regulation of the mouse carboxyl ester lipase gene in mammary gland

1998 • 25 citations

Mammary gland factor activated by prolactin on mammary epithelial cells and acute-phase response factor activated by interleukin-6 in liver cells share DNA binding and transactivation potential

1994 • 22 citations

Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription (Stat proteins).

1995 • 21 citations

Male-specific transcription initiation of theC4-Slpgene in mouse liver follows activation of STAT5

1998 • 20 citations

Growth Hormone-Induced Tyrosyl Phosphorylation and Deoxyribonucleic Acid Binding Activity of Stat5A and Stat5B

1997 • 19 citations

Prolactin induction of the alpha 2-Macroglobulin gene in rat ovarian granulosa cells: stat 5 activation and binding to the interleukin-6 response element

1996 • 19 citations

TheNab2andStat6Genes Share a Common Transcription Termination Region

1997 • 19 citations

Homodimerization of IL‐2 receptor β chain is necessary and sufficient to activate Jak2 and dowstream signaling pathways

1998 • 17 citations

Signal Transducer and Activator of Transcription-3 Serine Phosphorylation by Insulin Is Mediated by a Ras/Raf/MEK-Dependent Pathway

1997 • 16 citations

Binding of STAT5a and STAT5b to a Single Element Resembling a -Interferon-Activated Sequence Mediates the Growth Hormone Induction of the Mouse Acid-Labile Subunit Promoter in Liver Cells

1998 • 15 citations

Generation of Carboxy-Terminally Deleted Forms of STAT5 during Preparation of Cell Extracts

1999 • 13 citations

Modulation of the activation status of Stat5a during LIF-induced differentiation of M1 myeloid leukemia cells

1998 • 13 citations

Activity of Stat Family Transcription Factors is Developmentally Controlled in Cells of the Macrophage Lineage

1995 • 12 citations

Dominant Negative Variants of the SHP-2 Tyrosine Phosphatase Inhibit Prolactin Activation of Jak2 (Janus Kinase 2) and Induction of Stat5 (Signal Transducer and Activator of Transcription 5)-Dependent Transcription

1998 • 12 citations

JAK2 and STAT5, but not JAK1 and STAT1, Are Required for Prolactin-Induced -Lactoglobulin Transcription

1997 • 11 citations

Transcriptional Regulation of the -Casein Gene by Cytokines: Cross-Talk between STAT5 and Other Signaling Molecules

1998 • 6 citations

INDUCTION OF DIFFERENTIATION BY IL-6-TYPE CYTOKINES IS IMPAIRED IN MYELOID LEUKAEMIA CELLS UNABLE TO ACTIVATE Stat5a

1997 • 6 citations

Characterization of the Role of the Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Subunit in the Activation of JAK2 and STAT5

1998 • 6 citations

Physiological Function of Receptor-SH2 Interactions

1998 • 4 citations

Deleted Work

1955 • 0 citations