Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

STATs and Gene Regulation

1997 • 3,927 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1994 • 1,211 citations

The Role of Hemocytes in <b><i>Anopheles gambiae</i></b> Antiplasmodial Immunity

2013 • 1,046 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

The Ets family of transcription factors

1993 • 848 citations

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

1997 • 810 citations

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

1995 • 738 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

1996 • 565 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

1998 • 513 citations

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

1996 • 501 citations

P210 and P190 Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members

1996 • 498 citations

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid Leukemia

1997 • 494 citations

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

1996 • 452 citations

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

1997 • 416 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.

1995 • 399 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

Oligomerization of the ABL Tyrosine Kinase by the Ets Protein TEL in Human Leukemia

1996 • 349 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

1994 • 340 citations

FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

1998 • 332 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 312 citations

An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects.

1995 • 307 citations

Regulation of STAT‐dependent pathways by growth factors and cytokines

1996 • 297 citations

The novel activation of ABL by fusion to an ets-related gene, TEL.

1995 • 289 citations

Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.

1991 • 286 citations

The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFβR kinase-dependent signaling pathways

1996 • 285 citations

The t(12;21) Translocation Converts AML-1B from an Activator to a Repressor of Transcription

1996 • 284 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Structural and Signaling Requirements for BCR-ABL-Mediated Transformation and Inhibition of Apoptosis

1995 • 282 citations

Retrovirus-Mediated Gene Transfer of NPM-ALK Causes Lymphoid Malignancy in Mice

1997 • 278 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

1995 • 261 citations

Mutation in the Jak Kinase JH2 Domain Hyperactivates Drosophila and Mammalian Jak-Stat Pathways

1997 • 248 citations

B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.

1997 • 248 citations

Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.

1995 • 235 citations

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.

1996 • 232 citations

Retroviral-Mediated Transfer of the Green Fluorescent Protein Gene Into Murine Hematopoietic Cells Facilitates Scoring and Selection of Transduced Progenitors In Vitro and Identification of Genetically Modified Cells In Vivo

1997 • 230 citations

Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

1997 • 226 citations

kat: a high-efficiency retroviral transduction system for primary human T lymphocytes

1994 • 225 citations

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRbeta oncoprotein

1997 • 220 citations

A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.

1989 • 198 citations

Fusion of Huntingtin Interacting Protein 1 to Platelet-Derived Growth Factor β Receptor (PDGFβR) in Chronic Myelomonocytic Leukemia With t(5;7)(q33;q11.2)

1998 • 172 citations

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.

1992 • 167 citations

Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice.

1993 • 158 citations

Functionally Distinct Isoforms of STAT5 Are Generated by Protein Processing

1997 • 155 citations

Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7-dependent cell line.

1990 • 150 citations

The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway.

1996 • 146 citations

Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders.

1997 • 139 citations

Oncogenic activation of tyrosine kinases

1994 • 138 citations

Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2.

1994 • 136 citations

Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.

1995 • 121 citations

Construction of a bifunctional mRNA in the mouse by using the internal ribosomal entry site of the encephalomyocarditis virus.

1992 • 109 citations

Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression

1989 • 109 citations

The TEL gene products: nuclear phosphoproteins with DNA binding properties

1997 • 109 citations

The Kinase Domain of Jak2 Mediates Induction of Bcl-2 and Delays Cell Death in Hematopoietic Cells

1997 • 107 citations

IRES Bicistronic Expression Vectors for Efficient Creation of Stable Mammalian Cell Lines

1996 • 101 citations

Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides : tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

1997 • 93 citations

Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein.

1993 • 89 citations

An Epidermal Growth Factor Receptor/Jak2 Tyrosine Kinase Domain Chimera Induces Tyrosine Phosphorylation of Stat5 and Transduces a Growth Signal in Hematopoietic Cells

1996 • 85 citations

Roles of the JAK-STAT system in signal transduction via cytokine receptors

1996 • 81 citations

Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice.

1989 • 79 citations

Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes.

1995 • 74 citations

Hematologic disease induced in BALB/c mice by a bcr-abl retrovirus is influenced by the infection conditions.

1992 • 63 citations

Neurofibromatosis 2: loss of merlin's protective spell

1996 • 62 citations

Activation of Tyrosine Kinase and Microfilament-Binding Functions of c-abl by bcr Sequences in bcr/abl Fusion Proteins

1991 • 47 citations

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid Leukemia

1997 • 45 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 44 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 43 citations

Signal Transduction by a CD16/CD7/Jak2 Fusion Protein

1995 • 35 citations

Construction of a Bifunctional mRNA in the Mouse by Using the Internal Ribosomal Entry Site of the Encephalomyocarditis Virus

1992 • 34 citations

The Ets family of transcription factors

1994 • 23 citations

Cloning and Characterization of the Human Homolog of Mouse Jak2

1998 • 21 citations

kat: a high-efficiency retroviral transduction system for primary human T lymphocytes

1994 • 18 citations

Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression

1989 • 14 citations

Hematologic Disease Induced in BALB/c Mice by a bcr-abl Retrovirus Is Influenced by the Infection Conditions

1992 • 13 citations

Cloning and Characterization of the Human Homolog of Mouse Jak2

1998 • 4 citations