Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-γ and interleukin-4 receptor-α

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Protein modules and signalling networks

1995 • 2,447 citations

Cytokine signal transduction

1994 • 1,358 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

1993 • 1,084 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1994 • 888 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin

1989 • 833 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.

1993 • 565 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

The alphas, betas, and kinases of cytokine receptor complexes

1993 • 418 citations

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.

1996 • 406 citations

Activation of receptor-associated tyrosine kinase JAK2 by prolactin.

1994 • 354 citations

Receptor for Interleukin 13

1995 • 266 citations

The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor

1995 • 236 citations

Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex

1995 • 189 citations

Interleukin-13 Signal Transduction in Lymphohemopoietic Cells

1995 • 145 citations

IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.

1996 • 141 citations

Both Interleukin 4 and Interleukin 13 Induce Tyrosine Phosphorylation of the 140-kDa Subunit of the Interleukin 4 Receptor

1995 • 137 citations

Prolactin receptor triggering. Evidence for rapid tyrosine kinase activation.

1992 • 137 citations

Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15

1995 • 135 citations

Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R.

1992 • 135 citations

Design of human interleukin‐4 antagonists inhibiting interleukin‐4‐dependent and interleukin‐13‐dependent responses in T‐cells and B‐cells with high efficiency

1994 • 119 citations

Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.

1995 • 118 citations

Receptors for Interleukin (IL)-4 Do Not Associate with the Common γChain, and IL-4 Induces the Phosphorylation of JAK2 Tyrosine Kinase in Human Colon Carcinoma Cells

1995 • 117 citations

Signal Transduction Pathway of Interleukin-4 and Interleukin-13 in Human B Cells Derived from X-linked Severe Combined Immunodeficiency Patients

1996 • 102 citations

Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor β-chain

1995 • 92 citations

The proline-rich motif (PRM): a novel feature of the cytokine/hematopoietin receptor superfamily.

1993 • 85 citations

Characterization and Comparison of the Interleukin 13 Receptor with the Interleukin 4 Receptor on Several Cell Types

1995 • 79 citations

but Not JAK1 Activation of JAK3Is Critical to Interleukin-4 (IL4) Stimulated Proliferation and Requires a Membrane-proximal Region of IL4 Receptor α

1995 • 61 citations

The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor.

1995 • 59 citations

Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase.

1994 • 55 citations

Cloning of the Mouse Interleukin 2 Receptor γ Chain: Demonstration of Functional Differences Between the Mouse and Human Receptors

1993 • 52 citations

The insulin receptor substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13-mediated signal transduction

1995 • 39 citations

IL‐13 and IL‐4 share signal transduction elements as well as receptor components in TF‐1 cells

1995 • 39 citations

Human interleukin‐4 receptor signaling requires sequences contained within two cytoplasmic regions

1993 • 32 citations

Distinct sequence motifs within the cytoplasmic domain of the human IL-4 receptor differentially regulate apoptosis inhibition and cell growth.

1995 • 30 citations

Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.

1993 • 23 citations

Involvement of JAK-family tyrosine kinases in hematopoietin receptor signal transduction

1994 • 13 citations