SH2 Signaling in a Lower Eukaryote: A STAT Protein That Regulates Stalk Cell Differentiation in Dictyostelium

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

1996 • 8,994 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Analytical Properties of the Nanoelectrospray Ion Source

1996 • 1,816 citations

Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

1996 • 1,687 citations

Error-Tolerant Identification of Peptides in Sequence Databases by Peptide Sequence Tags

1994 • 1,475 citations

Growth of myxamoebae of the cellular slime mould Dictyostelium discoideum in axenic culture

1970 • 1,142 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

The protein kinases of budding yeast: six score and more

1997 • 473 citations

Identification of a Stat Gene That Functions in Drosophila Development

1996 • 397 citations

marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs

1996 • 375 citations

Chemical structure of the morphogen differentiation inducing factor from Dictyostelium discoideum

1987 • 371 citations

Cell differentiation without morphogenesis in Dictyostelium discoideum

1976 • 311 citations

Delayed Extraction Improves Specificity in Database Searches by Matrix-assisted Laser Desorption/Ionization Peptide Maps

1996 • 297 citations

Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.

1995 • 231 citations

Direct induction of dictyostelium prestalk gene expression by DIF provides evidence that DIF is a morphogen

1987 • 215 citations

A possible morphogen controlling differentiation in Dictyostelium

1983 • 180 citations

Origins of the prestalk-prespore pattern in Dictyostelium development

1989 • 179 citations

Three-dimensional solution structure of the src homology 2 domain of c-abl

1992 • 174 citations

Two distinct classes of prestalk-enriched mRNA sequences inDictyostelium discoideum

1987 • 169 citations

Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.

1994 • 150 citations

Culmination in dictyostelium is regulated by the cAMP-dependent protein kinase

1992 • 148 citations

Evidence for positional differentiation of prestalk cells and for a morphogenetic gradient in dictyostelium

1995 • 129 citations

Mutation of protein kinase A causes heterochronic development of Dictyostelium

1992 • 128 citations

Activation of the prespore and spore cell pathway of Dictyostelium differentiation by cAMP-dependent protein kinase and evidence for its upstream regulation by ammonia.

1993 • 126 citations

Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium

1991 • 123 citations

PSF and CMF, autocrine factors that regulate gene expression during growth and early development ofDictyostelium

1995 • 108 citations

Evidence that elevated intracellular cyclic AMP triggers spore maturation in Dictyostelium

1989 • 102 citations

Progression of an inductive signal activates sporulation in Dictyostelium discoideum

1994 • 83 citations

Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium

1992 • 81 citations

Developmentally regulated protein-tyrosine kinase genes in Dictyostelium discoideum.

1990 • 77 citations

cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development

1993 • 75 citations

Expression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium.

1994 • 72 citations

JAKs, STATs and signal transduction in response to the interferons and other cytokines

1996 • 71 citations

A specific DIF binding protein in Dictyostelium.

1990 • 63 citations

A repressor controls the timing and spatial localisation of stalk cell-specific gene expression in Dictyostelium

1993 • 58 citations

cudA: a Dictyostelium gene with pleiotropic effects on cellular differentiation and slug behaviour

1997 • 58 citations

The Dictyostelium dual-specificity kinase splA is essential for spore differentiation

1996 • 45 citations

Evidence that a combined activator-repressor protein regulates Dictyostelium stalk cell differentiation.

1996 • 39 citations

Sequence organization and developmental expression of an interspersed, repetitive element and associated single-copy DNA sequences in Dictyostelium discoideum.

1985 • 38 citations

Regulation by protein-tyrosine phosphatase PTP2 is distinct from that by PTP1 during Dictyostelium growth and development.

1994 • 35 citations

Multiple Roles of the Novel Protein Tyrosine Phosphatase PTP3 during Dictyostelium Growth and Development

1996 • 35 citations

Dual Effects of cAMP on the Stability of Prespore Vesicles and 8‐bromo cAMP‐enhanced Maturation of Spore and Stalk Cells of Dictyostelium discoideum

1988 • 32 citations

Classification of tyrosine kinases from Dictyostelium discoideum with two distinct, complete or incomplete catalytic domains

1996 • 32 citations

Analysis of the Maturation Process of Prestalk Cells in Dictyostelium discoideum

1993 • 27 citations

In vitro stalk cell differentiation in wild-type and ‘slugger’ mutants of Dictyostelium discoideum

1993 • 27 citations