Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

1982 • 2,228 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Cytokine signal transduction

1994 • 1,358 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

1994 • 1,079 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Characteristics of human large granular lymphocytes and relationship to natural killer and K cells

1981 • 1,008 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

The Interleukin-2 T-Cell System: A New Cell Growth Model

1984 • 935 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

1994 • 599 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

The IL-2 Receptor β Chain (p70): Role in Mediating Signals for LAK, NK, and Proliferative Activities

1987 • 444 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects.

1984 • 310 citations

IL-12 receptor. II. Distribution and regulation of receptor expression.

1992 • 298 citations

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

1992 • 284 citations

Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4

1993 • 256 citations

Hierarchical Control of Lymphocyte Survival

1996 • 255 citations

Recombinant interleukin 4 promotes the growth of human T cells.

1987 • 252 citations

A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells.

1992 • 245 citations

Identification and purification of human stat proteins activated in response to interleukin-2

1995 • 223 citations

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1994 • 211 citations

Cloning of Human Stat5B

1996 • 210 citations

Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice.

1993 • 178 citations

Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements.

1991 • 178 citations

Cytokine transcriptional events during helper T cell subset differentiation.

1996 • 174 citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1996 • 167 citations

IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures.

1988 • 167 citations

Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.

1996 • 162 citations

Functionally Distinct Isoforms of STAT5 Are Generated by Protein Processing

1997 • 155 citations

IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells.

1996 • 148 citations

Interleukin 2 signaling involves the phosphorylation of Stat proteins.

1995 • 124 citations

Cell surface phenotype of a cloned line of human natural killer cells.

1982 • 124 citations

The effects of IL-4 on human natural killer cells. A potent regulator of IL-2 activation and proliferation.

1988 • 118 citations

Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.

1991 • 115 citations

IL-12 Synergizes with IL-2 to Induce Lymphokine-Activated Cytotoxicity and Perforin and Granzyme Gene Expression in Fresh Human NK Cells

1995 • 112 citations

Cellular and molecular mechanisms of IFN-γ production induced by IL-2 and IL-12 in a human NK cell line

1995 • 108 citations

IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes.

1989 • 106 citations

Induction of proliferation in vitro of resting human natural killer cells: IL 2 induces into cell cycle most peripheral blood NK cells, but only a minor subset of low density T cells.

1986 • 104 citations

Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes

1996 • 93 citations

Novel interleukin 2 (IL-2) receptor appears to mediate IL-2-induced activation of natural killer cells.

1988 • 88 citations

IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells.

1990 • 77 citations

Distinct Tyrosine Residues within the Interleukin-2 Receptor β Chain Drive Signal Transduction Specificity, Redundancy, and Diversity

1996 • 75 citations

Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts

1996 • 75 citations

Immunoregulatory Effects of Cytokines on Natural Killer Cells

1994 • 72 citations

Receptor to nucleus signaling by prolactin and interleukin 2 via activation of latent DNA-binding factors.

1994 • 70 citations

Effects of IL-7 and IL-2 on highly enriched CD56+ natural killer cells. A comparative study.

1991 • 70 citations

Cytokine Receptor Signaling

2010 • 66 citations

IL-4/B cell stimulatory factor 1 stimulates T cell growth by an IL-2-independent mechanism.

1988 • 62 citations

Identification of a Conserved Lipopolysaccharide-Plus-Interleukin-4-Responsive Element Located at the Promoter of Germ Line ε Transcripts

1991 • 39 citations

Comparison of the effect of IL-2 and IL-6 on the lytic activity of purified human peripheral blood large granular lymphocytes.

1991 • 39 citations

Suppression of lymphokine-activated killer (LAK) cell induction mediated by interleukin-4 and transforming growth factor-β1: effect of addition of exogenous tumour necrosis factor-alpha and interferon-gamma, and measurement of their endogenous production

1990 • 29 citations

Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response. Critical role for IL-6.

1995 • 22 citations

Characteristics of interleukin-6-enhanced lymphokine-activated killer cell function

1991 • 22 citations

Enhancement by Monocytes of Perform Production and Its Gene Expression by Human CD8+ T Cells Stimulated with Interleukin‐2

1992 • 5 citations