Interferon gamma rapidly induces in human monocytes a DNA-binding factor that recognizes the gamma response region within the promoter of the gene for the high-affinity Fc gamma receptor.

Fc Receptors

1991 • 1,220 citations

γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

1985 • 949 citations

Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues

1984 • 486 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

Structure and Function of Human and Murine Receptors for IgG

1988 • 468 citations

Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

1988 • 428 citations

Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes.

1983 • 408 citations

Biology of Human Immunoglobulin G Fc Receptors

1991 • 403 citations

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

1987 • 398 citations

[28] Use and specificity of staurosporine, UCN-O1, and calphostin C as protein kinase inhibitors

1991 • 338 citations

Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter

1986 • 281 citations

Isolation and Expression of Functional High-Affinity Fc Receptor Complementary DNAs

1989 • 257 citations

Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.

1990 • 246 citations

IL-4 inhibits the expression of IL-8 from stimulated human monocytes.

1990 • 244 citations

Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3T3-L1 adipocytes.

1987 • 181 citations

Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements.

1991 • 178 citations

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.

1989 • 159 citations

Human chromosomes 6 and 21 are required for sensitivity to human interferon gamma.

1987 • 146 citations

Interferon-gamma-induced transcriptional activation is mediated by protein kinase C.

1988 • 137 citations

Transcriptional activation of HLA-DR alpha by interferon gamma requires a trans-acting protein.

1988 • 105 citations

Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function.

1991 • 97 citations

The characteristics of binding of human recombinant interferon-gamma to its receptor on human monocytes and human monocyte-like cell lines.

1985 • 80 citations

Phosphotyrosyl turnover in insulin signaling. Characterization of two membrane-bound pp15 protein tyrosine phosphatases from 3T3-L1 adipocytes.

1991 • 79 citations

Effect of phenylarsine oxide on insulin-dependent protein phosphorylation and glucose transport in 3T3-L1 adipocytes.

1987 • 79 citations

IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway.

1991 • 67 citations

Differential effect of monoclonal anti-DR antibody on monocytes in antigen- and mitogen-stimulated responses: Mechanism of inhibition and relationship to interleukin 1 secretion

1983 • 65 citations

The Extracellular Domain of the Human Interferon Gamma Receptor Interacts with a Species-Specific Signal Transducer

1991 • 52 citations

Interferon-gamma transcriptionally modulates the expression of the genes for the high affinity IgG-Fc receptor and the 47-kDa cytosolic component of NADPH oxidase in human polymorphonuclear leukocytes.

1991 • 51 citations

Insulin-induced p21ras activation does not require protein kinase C, but a protein sensitive to phenylarsine oxide.

1991 • 51 citations

Functional polymorphisms of Fc receptors in human monocyte-mediated cytotoxicity towards erythrocytes induced by murine isotype switch variants.

1989 • 50 citations

Functional characterization of a hybrid human-mouse interferon gamma receptor: evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer.

1992 • 50 citations

Identification of Gamma-Interferon as a Murine Macrophage-Activating Factor for Tumor Cytotoxicity

1984 • 40 citations

Antigen presentation at the inflammatory site.

1989 • 40 citations

Interferon-gamma-inducible regulation of the human invariant chain gene

1991 • 32 citations

Ligand-induced phosphorylation of the human interferon-gamma receptor. Dependence on the presence of a functionally active receptor.

1990 • 31 citations

Phorbol Ester-mediated Down-regulation of an Interferon-inducible Gene

1989 • 26 citations

Rapid increase of the human IFN-gamma receptor phosphorylation in response to human IFN-gamma and phorbol myristate acetate. Involvement of different serine/threonine kinases.

1990 • 26 citations

Internalization and degradation of human recombinant interferon-γ in the human histiocytic lymphoma cell line, U937: Relationship to Fc receptor enhancement and antiproliferation

1988 • 18 citations

Fc receptors and membrane immunoglobulin

1991 • 17 citations

The receptor for interferon-gamma on human peripheral blood monocytes consists of multiple distinct subunits.

1991 • 16 citations

Characterization of human IFN-? response using somatic cell hybrids of hematopoietic and nonhematopoietic origin

1989 • 10 citations