Mutational Analysis of Acute-Phase Response Factor/Stat3 Activation and Dimerization

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

1993 • 543 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

1992 • 530 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Induction of rat acute‐phase proteins by interleukin 6 in vivo

1988 • 412 citations

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

1993 • 411 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)

1992 • 378 citations

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

1995 • 363 citations

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.

1996 • 345 citations

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 310 citations

Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process

1995 • 303 citations

Role of STAT2 in the Alpha Interferon Signaling Pathway

1995 • 280 citations

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

1996 • 276 citations

Components of a stat recognition code: Evidence for two layers of molecular selectivity

1995 • 254 citations

The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.

1994 • 251 citations

Differential Activation of Acute Phase Response Factor/Stat3 and Stat1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 239 citations

Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets

1996 • 189 citations

The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements.

1994 • 181 citations

Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone

1995 • 180 citations

Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580

1996 • 171 citations

Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1

1996 • 153 citations

Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.

1994 • 152 citations

Granulocyte-Macrophage Colony-stimulating Factor Stimulates JAK2 Signaling Pathway and Rapidly Activates p93 , STAT1 p91, and STAT3 p92 in Polymorphonuclear Leukocytes

1996 • 133 citations

Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts

1995 • 119 citations

The membrane-distal cytoplasmic region of human granulocyte colony- stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation

1996 • 100 citations

Interleukin‐6‐induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin‐6 target gene induction

1995 • 97 citations

Activation of Protein Kinase A Inhibits Interferon Induction of the Jak/Stat Pathway in U266 Cells

1996 • 72 citations

Application of Genomic DNA Affinity Chromatography Identifies Multiple Interferon-α-regulated Stat2 Complexes

1996 • 66 citations