Regulation of the erythropoietin receptor and involvement of JAK2 in differentiation of J2E erythroid cells.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Erythropoietin: structure, control of production, and function

1992 • 1,158 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues

1984 • 486 citations

Enhanced Transcription of c- myc in Bursal Lymphoma Cells Requires Continuous Protein Synthesis

1985 • 469 citations

Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells

1988 • 406 citations

Transcripts from the Cellular Homologs of Retroviral Oncogenes: Distribution Among Chicken Tissues

1982 • 406 citations

Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity.

1995 • 374 citations

Structure, function, and activation of the erythropoietin receptor

1993 • 360 citations

Homodimerization and constitutive activation of the erythropoietin receptor.

1992 • 326 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor

1993 • 283 citations

The molecular mechanism of erythropoietin action

1992 • 274 citations

Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.

1991 • 231 citations

Induction of globin mRNA accumulation by hemin in cultured erythroleukemic cells

1976 • 228 citations

Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors

1985 • 227 citations

Binding and receptor-mediated endocytosis of erythropoietin in Friend virus-infected erythroid cells.

1987 • 227 citations

Activation of the erythropoietin receptor promoter by transcription factor GATA-1.

1991 • 225 citations

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.

1994 • 201 citations

Erythropoietin receptor. Subunit structure and activation.

1990 • 166 citations

Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo

1994 • 165 citations

Erythropoietin is both a mitogen and a survival factor

1991 • 158 citations

A Truncated Erythropoietin Receptor That Fails to Prevent Programmed Cell Death of Erythroid Cells

1992 • 156 citations

In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130.

1992 • 127 citations

The Effect of Erythropoietin on Colonial Growth of Erythroid Precursor Cells In Vitro

1974 • 125 citations

Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells.

1992 • 124 citations

Proliferative action of erythropoietin is associated with rapid protein tyrosine phosphorylation in responsive B6SUt.EP cells.

1991 • 115 citations

Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor.

1992 • 112 citations

Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells [see comments]

1992 • 110 citations

Expression of high affinity receptors for erythropoietin on human bone marrow cells and on the human erythroleukemic cell line, HEL.

1988 • 98 citations

In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin.

1988 • 93 citations

Erythropoietin receptor signals both proliferation and erythroid-specific differentiation.

1993 • 83 citations

Erythropoietin receptors on murine erythroid colony-forming units: natural history

1989 • 78 citations

Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line

1992 • 77 citations

Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes

1993 • 75 citations

The functional form of the erythropoietin receptor is a 78-kDa protein: correlation with cell surface expression, endocytosis, and phosphorylation.

1993 • 74 citations

Response to erythropoietin in erythroid subclones of the factor-dependent cell line 32D is determined by translocation of the erythropoietin receptor to the cell surface.

1991 • 66 citations

Erythropoietin-induced stimulation of differentiation and proliferation in J2E cells is not mimicked by chemical induction

1992 • 60 citations

Erythropoietin rapidly induces tyrosine phosphorylation in the human erythropoietin-dependent cell line, UT-7

1992 • 48 citations

Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing BA/F3 cells

1995 • 43 citations

Abundance and stability of erythropoietin receptor mRNA in mouse erythroid progenitor cells

1991 • 42 citations

Disrupted Signaling in a Mutant J2E Cell Line That Shows Enhanced Viability, but Does Not Proliferate or Differentiate, with Erythropoietin

1996 • 40 citations

Enhanced expression of interleukin-3 and granulocyte-macrophage colony- stimulating factor receptor subunits in murine hematopoietic cells stimulated with hematopoietic growth factors

1992 • 34 citations

The Major Erythroid DNA-binding Protein GATA-1 is Stimulated by Erythropoietin but not by Chemical Inducers of Erythroid Differentiation

1995 • 24 citations

Evolution of a mutant J2E erythroid cell line which does not respond to erythropoietin.

1990 • 20 citations

Erythropoietin Induced Ultrastructural Alterations to J2E Cells and Loss of Proliferative Capacity with Terminal Differentiation

1993 • 18 citations

Growth signal erythropoietin activates the same tyrosine kinases as interleukin 3, but activates only one tyrosine kinase as differentiation signal

1991 • 17 citations

Clonal Analysis of Erythropoietin Stimulated J2E Cells Reveals Asynchrony During Terminal Differentiation

1993 • 16 citations

Retrovirally-produced erythropoietin effectively induces differentiation and proliferation of J2E erythroid cells.

1993 • 15 citations

Erythropoietin exerts transcriptional and translational control over globin synthesis in J2E cells.

1995 • 14 citations

Factors controlling induction of commitment of murine erythroleukemia (TSA8) cells to CFU-E (colony forming unit-erythroid)

1987 • 14 citations

Amiloride Suppresses Erythropoietin-Induced Proliferation and MAP Kinase, but Potentiates Differentiation of J2E Cells

1995 • 13 citations

The erythropoietin receptor gene: cloning and identification of multiple transcripts in an erythroid cell line OCIM1.

1991 • 13 citations