Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Cytokine signal transduction

1994 • 1,358 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin

1989 • 833 citations

Growth of factor-dependent hemopoietic precursor cell lines.

1980 • 793 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

1985 • 718 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

Selective growth response to IL‐3 of a human leukaemic cell line with megakaryoblastic features

1988 • 314 citations

Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival.

1991 • 309 citations

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

1995 • 291 citations

Direct Association with and Dephosphorylation of Jak2 Kinase by the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-1

1996 • 291 citations

Erythropoietin Induces Activation of Stat5 through Association with Specific Tyrosines on the Receptor That Are Not Required for a Mitogenic Response

1996 • 272 citations

Cloning and Characterization of Novel CIS Family Genes

1997 • 259 citations

Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.

1991 • 231 citations

Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

1995 • 224 citations

Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.

1994 • 220 citations

Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

1995 • 218 citations

Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.

1996 • 206 citations

Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

1996 • 204 citations

Identification and analysis of human erythropoietin receptors on a factor-dependent cell line, TF-1

1989 • 146 citations

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

1993 • 133 citations

Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor.

1994 • 133 citations

Involvement of Proteasomes in Regulating Jak-STAT Pathways upon Interleukin-2 Stimulation

1997 • 133 citations

Interleukin-3, Erythropoietin, and Prolactin Activate a STAT5-like Factor in Lymphoid Cells

1995 • 128 citations

Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells.

1992 • 124 citations

Proliferative action of erythropoietin is associated with rapid protein tyrosine phosphorylation in responsive B6SUt.EP cells.

1991 • 115 citations

Erythropoietin Induces the Tyrosine Phosphorylation of Insulin Receptor Substrate-2

1997 • 105 citations

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

1993 • 101 citations

Erythropoietin induces the association of phosphatidylinositol 3′‐kinase with a tyrosine‐phosphorylated protein complex containing the erythropoietin receptor

1993 • 88 citations

Association of the p85 regulatory subunit of phosphatidylinositol 3- kinase with an essential erythropoietin receptor subdomain

1993 • 85 citations

Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation.

1996 • 83 citations

Structure of the murine erythropoietin receptor complex. Characterization of the erythropoietin cross-linked proteins.

1991 • 77 citations

Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line

1992 • 77 citations

Early events in erythropoietin-induced signaling.

1996 • 70 citations

The Signal Transduction Pathway of Erythropoietin Involves Three Forms of Mitogen‐Activated Protein (MAP) Kinase in UT7 Erythroleukemia Cells

1995 • 66 citations

Tyrosine phosphorylation of the erythropoietin receptor: role for differentiation and mitogenic signal transduction

1995 • 64 citations

Gene transfer and expression: A laboratory manual

1991 • 54 citations

Degradation of Monoubiquitinated .alpha.-Globin by 26S Proteasomes

1995 • 52 citations

Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage.

1992 • 29 citations

Monoubiquitinated alpha globin is an intermediate in the ATP-dependent proteolysis of alpha globin.

1994 • 20 citations

Glycosylation of the murine erythropoietin receptor

1990 • 16 citations