Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial

1998 • 2,668 citations

The activation of Akt/PKB signaling pathway and cell survival

2005 • 1,806 citations

Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

2002 • 1,599 citations

Global epidemiology of HTLV-I infection and associated diseases

2005 • 989 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

2002 • 845 citations

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

2001 • 727 citations

Centrosome aberrations: cause or consequence of cancer progression?

2002 • 725 citations

Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton

2003 • 711 citations

HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells

2006 • 567 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

The spindle checkpoint: structural insights into dynamic signalling

2002 • 526 citations

The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription

2002 • 471 citations

The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV

2003 • 449 citations

Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters

2005 • 441 citations

Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

1996 • 430 citations

Molecular mechanisms of cellular transformation by HTLV-1 Tax

2005 • 385 citations

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

1997 • 376 citations

Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteins

2003 • 364 citations

A new G‐CSF‐supported combination chemotherapy, LSG15, for adult T‐cell leukaemia‐lymphoma: Japan Clinical Oncology Group Study 9303

2001 • 349 citations

Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression.

2001 • 330 citations

HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene

1990 • 329 citations

Genetic and epigenetic inactivation of tax gene in adult T‐cell leukemia cells

2004 • 329 citations

Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy

1995 • 308 citations

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha

2001 • 294 citations

Constitutive Activation of NF-κB in Primary Adult T-Cell Leukemia Cells

1999 • 292 citations

A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n

1990 • 288 citations

Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I

2006 • 277 citations

Expression of FoxP3, a key molecule in CD4⁺CD25⁺ regulatory T cells, in adult T‐cell leukaemia/lymphoma cells

2004 • 276 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia

1996 • 248 citations

Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa

2005 • 239 citations

Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation

2001 • 238 citations

Activation of NF-κB by HTLV-I and implications for cell transformation

2005 • 225 citations

Discovery of adult T-cell leukemia

2005 • 223 citations

5′-Long Terminal Repeat-Selective CpG Methylation of Latent Human T-Cell Leukemia Virus Type 1 Provirus In Vitro and In Vivo

2002 • 220 citations

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

2005 • 219 citations

The HBZ Factor of Human T-cell Leukemia Virus Type I Dimerizes with Transcription Factors JunB and c-Jun and Modulates Their Transcriptional Activity

2003 • 206 citations

Recognition of a chromosome truncation site associated with α-thalassaemia by human telomerase

1991 • 205 citations

Healing of broken human chromosomes by the addition of telomeric repeats.

1994 • 204 citations

Cellular immune response to HTLV-1

2005 • 200 citations

Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1

2006 • 194 citations

Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb

1998 • 188 citations

Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms

2005 • 187 citations

The discovery of the first human retrovirus: HTLV-1 and HTLV-2

2005 • 186 citations

The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

2000 • 184 citations

Heterozygous Deletion of Mitotic Arrest–Deficient Protein 1 (MAD1) Increases the Incidence of Tumors in Mice

2007 • 182 citations

Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia

2001 • 179 citations

Activated AKT regulates NF-κB activation, p53 inhibition and cell survival in HTLV-1-transformed cells

2005 • 179 citations

HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication

2004 • 174 citations

Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer

2006 • 171 citations

Persistent clonal proliferation of human T-lymphotropic virus type I-infected cells in vivo.

1997 • 167 citations

HTLV-I antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylated

2006 • 165 citations

Selective Ablation of Human T-Cell Lymphotropic Virus Type 1 p12I Reduces Viral Infectivity In Vivo

1998 • 162 citations

Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)

2005 • 157 citations

Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma

2005 • 156 citations

Impaired production of naive T lymphocytes in human T-cell leukemia virus type I–infected individuals: its implications in the immunodeficient state

2001 • 154 citations

Graft-versus-Tax Response in Adult T-Cell Leukemia Patients after Hematopoietic Stem Cell Transplantation

2004 • 145 citations

Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis

2005 • 140 citations

Human T-cell Leukemia Virus minus strand transcription in infected T-cells

1989 • 140 citations

Involvement of Crm1 in Hepatitis B Virus X Protein-Induced Aberrant Centriole Replication and Abnormal Mitotic Spindles

2003 • 140 citations

Physical Interaction of Human T-Cell Leukemia Virus Type 1 Tax with Cyclin-Dependent Kinase 4 Stimulates the Phosphorylation of Retinoblastoma Protein

2002 • 140 citations

Evaluation of adult T-cell leukemia/lymphoma incidence and its impact on non-Hodgkin lymphoma incidence in southwestern Japan

2000 • 140 citations

Human T-lymphotropic Virus, Type 1, Tax Protein Triggers Microtubule Reorientation in the Virological Synapse

2005 • 138 citations

HBZ interacts with JunD and stimulates its transcriptional activity

2004 • 137 citations

Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-κB Pathway and Is Dependent on p53 Phosphorylation

2000 • 136 citations

Stimulation of Cyclin-Dependent Kinase Activity and G₁- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein

1998 • 133 citations

Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I

2001 • 131 citations

Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro

2004 • 131 citations

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a

1997 • 131 citations

Expression of cell-cycle regulatory genes in HTLV-I infected T-cell lines: possible involvement of Tax1 in the altered expression of cyclin D2, p18Ink4 and p21Waf1/Cip1/Sdi1.

1996 • 128 citations

Dating the Origin of the African Human T-Cell Lymphotropic Virus Type-I (HTLV-I) Subtypes

2001 • 126 citations

Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF- B, as a strategy for chemoprevention and therapy of adult T-cell leukemia

2005 • 126 citations

Free Major Histocompatibility Complex Class I Heavy Chain Is Preferentially Targeted for Degradation by Human T-Cell Leukemia/Lymphotropic Virus Type 1 p12^IProtein

2001 • 123 citations

Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control

1999 • 122 citations

Down-regulation of the INK4 Family of Cyclin-Dependent Kinase Inhibitors by Tax Protein of HTLV-1 through Two Distinct Mechanisms

1999 • 119 citations

Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1

1995 • 119 citations

HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

2000 • 118 citations

Defective DNA Repair in Cells With Human T-Cell Leukemia/Bovine Leukemia Viruses: Role of tax Gene

1999 • 117 citations

Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1–infected lymphocytes

2005 • 114 citations

HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule

2004 • 113 citations

Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells

2005 • 112 citations

Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy

1998 • 110 citations

Prevalent Loss of Mitotic Spindle Checkpoint in Adult T-cell Leukemia Confers Resistance to Microtubule Inhibitors

2002 • 110 citations

Zidovudine plus lamivudine in Human T-Lymphotropic Virus type-I-associated myelopathy: a randomised trial

2006 • 109 citations

The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation

2004 • 107 citations

Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells

2006 • 102 citations

Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence

2006 • 94 citations

Endoplasmic Reticulum andcis-Golgi Localization of Human T-Lymphotropic Virus Type 1 p12^I: Association with Calreticulin and Calnexin

2001 • 92 citations

PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line

2003 • 92 citations

Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells

1999 • 92 citations

HBZ, a new important player in the mystery of adult T-cell leukemia

2006 • 90 citations

Inactivation of hTERT transcription by Tax

2003 • 89 citations

Role for Akt/Protein Kinase B and Activator Protein-1 in Cellular Proliferation Induced by the Human T-cell Leukemia Virus Type 1 Tax Oncoprotein

2006 • 87 citations

Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein

2005 • 85 citations

Involvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4+25+ HTLV-1-infected T-cells in human carriers of both HTLV-1 and S. stercoralis

2002 • 83 citations

Centrosome Amplification and the Origin of Chromosomal Instability in Breast Cancer

2004 • 83 citations

Tax-Independent Constitutive IκB Kinase Activation in Adult T-Cell Leukemia Cells

2004 • 80 citations

Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T‐cell leukemia

2006 • 80 citations

Human T-Lymphotropic Virus Type 1 p30 ^II Functions as a Transcription Factor and Differentially Modulates CREB-Responsive Promoters

2000 • 80 citations

Human T-Cell Lymphotropic Virus Type 1 Open Reading Frame II-Encoded p30 ^II Is Required for In Vivo Replication: Evidence of In Vivo Reversion

2004 • 79 citations

The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication

2006 • 78 citations

Clastogenic Effect of the Human T-cell Leukemia Virus Type I Tax Oncoprotein Correlates with Unstabilized DNA Breaks

2000 • 73 citations

Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states

2005 • 73 citations

Human T-Cell Leukemia Virus Type 2 (HTLV-2) Tax Protein Transforms a Rat Fibroblast Cell Line but Less Efficiently than HTLV-1 Tax

2002 • 71 citations

Tax-Independent Constitutive IκB Kinase Activation in Adult T-Cell Leukemia Cells

2004 • 70 citations

Induction of ICAM‐1 and LFA‐3 by Tax1 of human T‐cell leukemia virus type 1 and mechanism of down‐regulation of ICAM‐1 or LFA‐1 in adult‐T‐cell‐leukemia cell lines

1995 • 69 citations

Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1

2004 • 68 citations

Ancient Origin and Molecular Features of the Novel Human T-Lymphotropic Virus Type 3 Revealed by Complete Genome Analysis

2006 • 68 citations

Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications

2005 • 68 citations

Activation of E2F-mediated Transcription by Human T-cell Leukemia Virus Type I Tax Protein in a p16 -negative T-cell Line

1998 • 67 citations

The Low Evolutionary Rate of Human T-Cell Lymphotropic Virus Type-1 Confirmed by Analysis of Vertical Transmission Chains

2003 • 67 citations

Segregation of NF-κB activation through NEMO/IKKγ by Tax and TNFα: implications for stimulus-specific interruption of oncogenic signaling

2003 • 66 citations

Modulation of Nuclear Factor-κB by Human T Cell Leukemia Virus Type 1 Tax Protein: Implications for Oncogenesis and Inflammation

2006 • 63 citations

Centrosome abnormalities and genomic instability induced by human papillomavirus oncoproteins.

2003 • 62 citations

Telomerase activity and telomere length as prognostic factors of adult T-cell leukemia

2004 • 61 citations

Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression

2003 • 61 citations

Differential transactivation of the intercellular adhesion molecule 1 gene promoter by Tax1 and Tax2 of human T-cell leukemia viruses

1996 • 60 citations

Human T-cell leukemia virus infection of human hematopoietic progenitor cells: maintenance of virus infection during differentiation in vitro and in vivo

1996 • 60 citations

Epstein-Barr Virus-Induced Resistance to Drugs That Activate the Mitotic Spindle Assembly Checkpoint in Burkitt's Lymphoma Cells

2006 • 57 citations

Enhancement of LFA-1-Mediated T Cell Adhesion by Human T Lymphotropic Virus Type 1 p12I1

2006 • 57 citations

Rapid quantification of HTLV-I provirus load: Detection of monoclonal proliferation of HTLV-I-infected cells among blood donors

1999 • 55 citations

Correlation of telomerase activity with development and progression of adult T-cell leukemia

1999 • 55 citations

GLUT1 Is Not the Primary Binding Receptor but Is Associated with Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1

2006 • 55 citations

Damaged DNA and miscounted chromosomes: Human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells

2002 • 54 citations

De Novo Human T-Cell Leukemia Virus Type 1 Infection of Human Lymphocytes in NOD-SCID, Common γ-Chain Knockout Mice

2006 • 53 citations

Reduced expression of human mismatch repair genes in adult T-cell leukemia

2005 • 52 citations

Human T-Lymphotropic Virus Type 1 Mitochondrion-Localizing Protein p13 ^II Is Required for Viral Infectivity In Vivo

2006 • 51 citations

The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells.

2004 • 51 citations

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells

2009 • 49 citations

The HTLV-1 Tax Oncoprotein Attenuates DNA Damage Induced G1 Arrest and Enhances Apoptosis in p53 Null Cells

2003 • 49 citations

Human T-Cell Leukemia Virus Type I at Age 25: A Progress Report

2005 • 47 citations

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells

2004 • 46 citations

Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein

1997 • 45 citations

Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-κB activation

2005 • 45 citations

Characterization of Regions in hsMAD1 Needed for Binding hsMAD2

2002 • 44 citations

The Human T Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein Represses MyoD-dependent Transcription by Inhibiting MyoD-binding to the KIX Domain of p300

2000 • 43 citations

Aneuploidy theory explains tumor formation, the absence of immune surveillance, and the failure of chemotherapy

2002 • 40 citations

Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells

2005 • 37 citations

Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells

2006 • 37 citations

Evidence for NF-κB- and CBP-Independent Repression of p53's Transcriptional Activity by Human T-Cell Leukemia Virus Type 1 Tax in Mouse Embryo and Primary Human Fibroblasts

2005 • 37 citations

Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein

2006 • 30 citations

Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells.

2004 • 29 citations

The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix

2005 • 29 citations

p53-Independent Induction of Apoptosis by the HTLV-I Tax Protein Following UV Irradiation

2001 • 25 citations

Human T-Cell Leukemia Virus Type 1 Expressing Nonoverlapping Tax and Rex Genes Replicates and Immortalizes Primary Human T Lymphocytes but Fails To Replicate and Persist In Vivo

2005 • 17 citations

DNA aneuploidy of adult T-cell leukemia cells

1994 • 16 citations

Human T-Cell Leukemia Virus Type 1 Tax Protein Down-Regulates Pre-T-Cell Receptor Alpha Gene Transcription in Human Immature Thymocytes

2006 • 15 citations

Concurrence of lymphoma type adult T-cell leukemia in three sisters

1985 • 15 citations