Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death

2001 • 482 citations

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1996 • 478 citations

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1999 • 397 citations

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

1983 • 345 citations

A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n

1990 • 288 citations

Double Strand Break Repair

1997 • 268 citations

Genomic integrity and the repair of double-strand DNA breaks

2001 • 247 citations

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.

1994 • 238 citations

Cell cycle-dependent modulation of telomerase activity in tumor cells.

1996 • 226 citations

Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks.

1994 • 215 citations

Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis

1999 • 176 citations

Life, Death, and Tax: Role of HTLV-I Oncoprotein in Genetic Instability and Cellular Transformation

2004 • 169 citations

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

2001 • 159 citations

The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells.

1993 • 155 citations

Identification and Biochemical Characterization of a Werner's Syndrome Protein Complex with Ku70/80 and Poly(ADP-ribose) Polymerase-1

2004 • 142 citations

Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro

1999 • 118 citations

Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.

2002 • 117 citations

Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions

1999 • 101 citations

HTLV-I and HTLV-II Tax: Differences in Induction of Micronuclei in Cells and Transcriptional Activation of Viral LTRs

1996 • 90 citations

Inactivation of hTERT transcription by Tax

2003 • 89 citations

Induction of Micronuclei by HTLV-I Tax: A Cellular Assay for Function

1993 • 89 citations

Telomere repeat binding factors: keeping the ends in check

2003 • 85 citations

Expression Profile of the Telomeric Complex Discriminates between Benign and Malignant Pheochromocytoma

2003 • 79 citations

Clastogenic Effect of the Human T-cell Leukemia Virus Type I Tax Oncoprotein Correlates with Unstabilized DNA Breaks

2000 • 73 citations

Telomerase and tumorigenesis

2003 • 72 citations

Telomerase Activity Is Significantly Enhanced in Malignant Adrenocortical Tumors in Comparison to Benign Adrenocortical Adenomas

2000 • 37 citations

Telomeres: Moonlighting by DNA repair proteins

1998 • 33 citations

Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation

2005 • 31 citations

The Interplay between Nonhomologous End-joining and Cell Cycle Checkpoint Factors in Development, Genomic Stability, and Tumorigenesis

2000 • 19 citations