Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells

Genetic instabilities in human cancers

1998 • 4,165 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 2,119 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 1,750 citations

Diagnostic criteria and classification of clinical subtypes of adult T‐cell leukaemia‐lymphoma

1991 • 1,527 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

1999 • 784 citations

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

2000 • 483 citations

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A

1999 • 476 citations

Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control

2001 • 457 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

1990 • 439 citations

Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

1995 • 364 citations

Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.

1989 • 359 citations

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

1999 • 329 citations

Centrosome amplification, chromosome instability and cancer development

2005 • 310 citations

Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression

1999 • 284 citations

Centrosome amplification and the development of cancer

2002 • 277 citations

The immune control and cell-to-cell spread of human T-lymphotropic virus type 1

2003 • 257 citations

Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat

1989 • 239 citations

Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia

1989 • 204 citations

Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response

2005 • 188 citations

The centrosome cycle

2002 • 163 citations

Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)

2005 • 157 citations

Chromosome abnormalities in adult T-cell leukemia/lymphoma: a karyotype review committee report.

1992 • 144 citations

CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation

1997 • 138 citations

Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I

2001 • 131 citations

p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells

1999 • 116 citations

The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation

2004 • 107 citations

Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

2005 • 101 citations

Micronuclei: a biological indicator of radiation damage

1996 • 101 citations

p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells

1999 • 100 citations

Multi-step control of spindle pole body duplication by cyclin-dependent kinase

2000 • 100 citations

Induction of Micronuclei by HTLV-I Tax: A Cellular Assay for Function

1993 • 89 citations

Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein

2005 • 85 citations

Centrosome aberrations in hematological malignancies

2005 • 74 citations

Cyclin-dependent kinase inhibitor indirubin-3′-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies

2004 • 61 citations

The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells.

2004 • 51 citations

Infection of rats with HTLV‐1: A small‐animal model for HTLV‐1 carriers

1991 • 50 citations

Direct Binding of the N-Terminus of HTLV-1 Tax Oncoprotein to Cyclin-Dependent Kinase 4 Is a Dominant Path To Stimulate the Kinase Activity

2003 • 35 citations

Quantitation of HTLV‐I provirus among seropositive blood donors: Relation with antibody profile using synthetic peptides

1993 • 12 citations