Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-κB activation

Signaling to NF-κB

2004 • 3,768 citations

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

Plat-E: an efficient and stable system for transient packaging of retroviruses

2000 • 1,614 citations

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

2002 • 873 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control

2001 • 457 citations

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering

1987 • 438 citations

RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase

1998 • 425 citations

Regulation of the human interleukin-2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I

1987 • 423 citations

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

1987 • 413 citations

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

2002 • 395 citations

MEKK1 activates both IκB kinase α and IκB kinase β

1998 • 382 citations

Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture

1992 • 311 citations

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha

2001 • 294 citations

Constitutive Activation of NF-κB in Primary Adult T-Cell Leukemia Cells

1999 • 292 citations

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

1989 • 289 citations

Bay 11-7082 inhibits transcription factor NF-kappa B and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells

2002 • 276 citations

Efficient screening of retroviral cDNA expression libraries.

1995 • 244 citations

The Epstein–Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation

1997 • 224 citations

Induction of Bcl-x_LExpression by Human T-Cell Leukemia Virus Type 1 Tax through NF-κB in Apoptosis-Resistant T-Cell Transfectants with Tax

1999 • 214 citations

MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival

2003 • 214 citations

Ligand-independent signaling by overexpressed CD30 drives NF-κB activation in Hodgkin–Reed-Sternberg cells

2002 • 207 citations

Immortalization of CD4⁺and CD8⁺T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone

1999 • 204 citations

Cell surface phenotypes and expression of viral antigens of various human cell lines carrying human T‐cell leukemia virus

1984 • 193 citations

Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.

1996 • 193 citations

Human T-cell leukemia virus type I and adult T-cell leukemia

2003 • 192 citations

Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia

2001 • 179 citations

HTLV-1 Tax induces expression of various immediate early serum responsive genes.

1991 • 177 citations

Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-κB site

1998 • 176 citations

Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain

1998 • 174 citations

The Tax Oncoprotein of Human T-cell Leukemia Virus Type 1 Associates with and Persistently Activates IκB Kinases Containing IKKα and IKKβ

1998 • 152 citations

Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I

2001 • 131 citations

Repression of Bax Gene Expression by the HTLV-I Tax Protein: Implications for Suppression of Apoptosis in Virally Infected Cells

1997 • 131 citations

Expression of cell-cycle regulatory genes in HTLV-I infected T-cell lines: possible involvement of Tax1 in the altered expression of cyclin D2, p18Ink4 and p21Waf1/Cip1/Sdi1.

1996 • 128 citations

Fas Gene Mutation in the Progression of Adult T Cell Leukemia

1999 • 124 citations

CD30 Ligand Is Frequently Expressed in Human Hematopoietic Malignancies of Myeloid and Lymphoid Origin

1997 • 119 citations

Proliferative response of Tax1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway

1993 • 113 citations

Somatic mutagenesis studies of NF-κB signaling in human T cells: evidence for an essential role of IKKγ in NF-κB activation by T-cell costimulatory signals and HTLV-I Tax protein

2000 • 111 citations

Inhibition of Caspase Cascade by HTLV-I Tax Through Induction of NF-κB Nuclear Translocation

1999 • 98 citations

Human T Cell Lymphotropic Virus Type I Tax Activates IL-15Rα Gene Expression Through an NF-κB Site

2001 • 95 citations

Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways.

2001 • 95 citations

Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells

1995 • 93 citations

Features of the Cytokines Secreted by Adult T Cell Leukemia (ATL) Cells

1996 • 93 citations

Rip2 Participates in Bcl10 Signaling and T-cell Receptor-mediated NF-κB Activation

2004 • 92 citations

Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells

1999 • 92 citations

HTLV-1 tax activation of the GM-CSF and G-CSF promoters requires the interaction of NF-kB with other transcription factor families.

1993 • 87 citations

Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes

1997 • 82 citations

Tax-Independent Constitutive IκB Kinase Activation in Adult T-Cell Leukemia Cells

2004 • 80 citations

Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation.

1995 • 79 citations

TCR-Independent CD30 Signaling Selectively Induces IL-13 Production Via a TNF Receptor-Associated Factor/p38 Mitogen-Activated Protein Kinase-Dependent Mechanism

2002 • 70 citations

Tax-Independent Constitutive IκB Kinase Activation in Adult T-Cell Leukemia Cells

2004 • 70 citations

Pleiotropic Signal Transduction Mediated by Human CD30: A Member of the Tumor Necrosis Factor Receptor (TNFR) Family

2002 • 67 citations

Cytoplasmic Aggregation of TRAF2 and TRAF5 Proteins in the Hodgkin-Reed-Sternberg Cells

2002 • 64 citations

Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines.

1994 • 62 citations

The role of CD30 in the pathogenesis of haematopoietic malignancies

2004 • 54 citations

Detection of a soluble form of the CD30 antigen in sera of patients with lymphoma, adult T‐cell leukemia and infectious mononucleosis

1990 • 53 citations

Human Retroviruses: HTLV-I and HTLV-II

1993 • 49 citations

Activation of cyclin D1 and D2 promoters by human T‐cell leukemia virus type I tax protein is associated with IL‐2–independent growth of T cells

2002 • 47 citations

Negative Regulation of the Nuclear Factor κB-inducing Kinase by a cis-Acting Domain

2000 • 42 citations

Interleukin-13 Overexpression by Tax Transactivation: a Potential Autocrine Stimulus in Human T-Cell Leukemia Virus-Infected Lymphocytes

2004 • 41 citations

IL-2-Dependent ATL cell lines with phenotypes differing from the original leukemia cells

1991 • 35 citations

Activation of I-κB Kinase by the HTLV Type 1 Tax Protein: Mechanistic Insights into the Adaptor Function of IKKγ

2000 • 33 citations

A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages

1996 • 33 citations

Clinicopathological Features of Adult T-Cell Leukemia with CD30 Antigen Expression

1994 • 20 citations

HTLV-1 proviruses encoding non-functional TAX in adult T-cell leukemia.

2001 • 17 citations