Role for Akt/Protein Kinase B and Activator Protein-1 in Cellular Proliferation Induced by the Human T-cell Leukemia Virus Type 1 Tax Oncoprotein

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

1981 • 2,281 citations

PI3K/Akt signalling pathway and cancer

2003 • 2,157 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

The activation of Akt/PKB signaling pathway and cell survival

2005 • 1,806 citations

AP-1 in cell proliferation and survival

2001 • 1,686 citations

The protein kinase B/Akt signalling pathway in human malignancy

2002 • 1,609 citations

Targeting the PI3K-Akt pathway in human cancer

2003 • 1,262 citations

PI3K-Akt pathway: Its functions and alterations in human cancer

2004 • 1,201 citations

Ten years of protein kinase B signalling: a hard Akt to follow

2001 • 1,159 citations

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1998 • 1,097 citations

AKT plays a central role in tumorigenesis

2001 • 932 citations

Induction of NF-κB by the Akt/PKB kinase

1999 • 847 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Structure, regulation and function of PKB/AKT—a major therapeutic target

2003 • 695 citations

Activation of the PI3K/Akt pathway and chemotherapeutic resistance

2002 • 576 citations

PKB Binding Proteins

2002 • 528 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

1998 • 508 citations

The expanding TOR signaling network

2005 • 499 citations

Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control

2001 • 457 citations

Expression of the c- fos Gene and of an fos -Related Gene Is Stimulated by Platelet-Derived Growth Factor

1984 • 445 citations

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.

1990 • 401 citations

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

1999 • 387 citations

Molecular mechanisms of cellular transformation by HTLV-1 Tax

2005 • 385 citations

c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

1988 • 361 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

The activation of phosphatidylinositol 3-kinase by Ras

1994 • 322 citations

Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival

2002 • 284 citations

Protein kinase B (PKB/Akt) – a key regulator of glucose transport?

2001 • 274 citations

Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2

2002 • 268 citations

The PI‐3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP₃

2003 • 264 citations

Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

2002 • 245 citations

A sustained activation of PI3K/NF-κB pathway is critical for the survival of chronic lymphocytic leukemia B cells

2004 • 240 citations

Discovery of adult T-cell leukemia

2005 • 223 citations

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells.

1990 • 222 citations

Immortalization of CD4⁺and CD8⁺T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone

1999 • 204 citations

Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

2002 • 197 citations

The discovery of the first human retrovirus: HTLV-1 and HTLV-2

2005 • 186 citations

The Hepatitis B Virus-X Protein Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade

2001 • 181 citations

Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A

2005 • 174 citations

Life, Death, and Tax: Role of HTLV-I Oncoprotein in Genetic Instability and Cellular Transformation

2004 • 169 citations

Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)

2005 • 157 citations

Phosphorylation of the Carboxyl-Terminal Transactivation Domain of c-Fos by Extracellular Signal-Regulated Kinase Mediates the Transcriptional Activation of AP-1 and Cellular Transformation Induced by Platelet-Derived Growth Factor

2003 • 147 citations

Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins

1992 • 135 citations

Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-κB

2001 • 126 citations

Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway.

1991 • 124 citations

A Human Suppressor of c-Jun N-terminal Kinase 1 Activation by Tumor Necrosis Factor α

1997 • 102 citations

Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells.

2000 • 96 citations

Human T-cell lymphotropic virus oncoprotein Tax represses TGF-β1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis

2002 • 93 citations

Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis.

1996 • 92 citations

Regulation of Protein Kinase B

1999 • 86 citations

A Human T-cell Leukemia Virus Tax Variant Incapable of Activating NF-κB Retains Its Immortalizing Potential for Primary T-lymphocytes

1998 • 86 citations

Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein

2005 • 85 citations

Increased proviral load in HTLV-1-infected patients with rheumatoid arthritis or connective tissue disease.

2005 • 84 citations

Regulation of human T cell leukemia virus expression ¹

1990 • 78 citations

Clastogenic Effect of the Human T-cell Leukemia Virus Type I Tax Oncoprotein Correlates with Unstabilized DNA Breaks

2000 • 73 citations

PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer.

2000 • 72 citations

Quantification of the virus-host interaction in human T lymphotropic virus I infection

2005 • 66 citations

Human T-Cell Leukemia Virus Type 1 Tax Protein Activates Transcription through AP-1 Site by Inducing DNA Binding Activity in T Cells

2001 • 66 citations

Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax

2001 • 64 citations

LY294002 and rapamycin co‐operate to inhibit T‐cell proliferation

2005 • 63 citations

Damaged DNA and miscounted chromosomes: Human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells

2002 • 54 citations

The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells.

2004 • 51 citations

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells

2009 • 49 citations

The Tax Protein of Human T-cell Leukemia Virus Type 1 Mediates the Transactivation of the c-sis/Platelet-derived Growth Factor-B Promoter through Interactions with the Zinc Finger Transcription Factors Sp1 and NGFI-A/Egr-1

1997 • 47 citations

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells

2004 • 46 citations

Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells

2005 • 37 citations

Cyclin A Is a c-Jun Target Gene and Is Necessary for c-Jun-induced Anchorage-independent Growth in RAT1a Cells

2005 • 37 citations

Activation of Oncogenic Transcription Factor AP-1 in T Cells Infected with Human T Cell Leukemia Virus Type 1

2000 • 35 citations

The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix

2005 • 29 citations

Involvement of the phosphoinositide 3-kinase/Akt signaling pathway in the resistance to therapeutic treatments of human leukemias.

2005 • 29 citations

Viral Transformation Of Human T Lymphocytes

1994 • 26 citations

Inducing cancer cell death by targeting transcription factors

2003 • 22 citations

Adult T-cell leukemia: future prophylaxis and immunotherapy

2004 • 18 citations

Constitutive cytokine release by simian T-cell lymphotrophic virus type I (STLV-I) and human T-cell lymphotrophic virus types I/II (HTLV-I/II) transformed cell lines

1996 • 9 citations

Role of kinases in HTLV-I transformation.

1996 • 5 citations

Deleted Work

1955 • 0 citations