Centrosome aberrations: cause or consequence of cancer progression?

Genetic instabilities in human cancers

1998 • 4,165 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Catalog of chromosome aberrations in cancer

1985 • 1,522 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A Structural Scaffolding of Intermediate Filaments in Health and Disease

1998 • 1,003 citations

Nucleation of microtubule assembly by a γ-tubulin-containing ring complex

1995 • 851 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 796 citations

Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

2000 • 704 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

1999 • 613 citations

Centrosome defects and genetic instability in malignant tumors.

1998 • 583 citations

Centrosome amplification drives chromosomal instability in breast tumor development

2002 • 564 citations

Centrosome composition and microtubule anchoring mechanisms

2002 • 557 citations

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

1998 • 515 citations

Catalog of chromosome aberrations in cancer

1989 • 514 citations

Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts

1999 • 505 citations

Genomic instability in Gadd45a-deficient mice

1999 • 499 citations

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

1998 • 498 citations

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

2000 • 483 citations

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A

1999 • 476 citations

Chromosome segregation and cancer: cutting through the mystery

2001 • 459 citations

The Mitotic Spindle: A Self-Made Machine

2001 • 447 citations

Cyclin-dependent kinase control of centrosome duplication

1999 • 423 citations

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

2001 • 413 citations

Managing the centrosome numbers game: from chaos to stability in cancer cell division

2001 • 402 citations

Centrosome-Dependent Exit of Cytokinesis in Animal Cells

2001 • 396 citations

Re-evaluating centrosome function

2001 • 392 citations

Four-dimensional control of the cell cycle

1999 • 386 citations

Centrosome organization and centriole architecture: Their sensitivity to divalent cations

1992 • 365 citations

17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus.

1996 • 358 citations

Centrosomes Enhance the Fidelity of Cytokinesis in Vertebrates and Are Required for Cell Cycle Progression

2001 • 340 citations

Recurrent chromosome aberrations in cancer

2000 • 337 citations

Requirement of a Centrosomal Activity for Cell Cycle Progression Through G ₁ into S Phase

2001 • 336 citations

Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression.

2001 • 330 citations

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

1999 • 329 citations

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

1999 • 315 citations

Asymmetric cell division during animal development

2001 • 306 citations

Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells.

1995 • 301 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 294 citations

Structural and chemical characterization of isolated centrosomes

1987 • 292 citations

Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression

1999 • 284 citations

Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: A phenotype/genotype correlation

1999 • 282 citations

“It Takes Two to Tango”: understanding how centrosome duplication is regulated throughout the cell cycle

2001 • 279 citations

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

2000 • 274 citations

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

1996 • 266 citations

The TACC domain identifies a family of centrosomal proteins that can interact with microtubules

2000 • 265 citations

Model for the genetic evolution of human solid tumors.

1989 • 251 citations

The paternal inheritance of the centrosome, the cell's microtubule-organizing center, in humans, and the implications for infertility

1995 • 248 citations

Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation

2000 • 234 citations

The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion

2000 • 232 citations

The centrosome in vertebrates: more than a microtubule-organizing center

2001 • 232 citations

Aneuploidy, the somatic mutation that makes cancer a species of its own

2000 • 214 citations

Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells.

1994 • 209 citations

De novo formation of centrosomes in vertebrate cells arrested during S phase

2002 • 204 citations

Direct Interaction of Pericentrin with Cytoplasmic Dynein Light Intermediate Chain Contributes to Mitotic Spindle Organization

1999 • 203 citations

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

1999 • 201 citations

The mitotic machinery as a source of genetic instability in cancer

1999 • 201 citations

Altered Centrosome Structure Is Associated with Abnormal Mitoses in Human Breast Tumors

1999 • 200 citations

Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype.

2001 • 197 citations

Mode of centriole duplication and distribution.

1990 • 197 citations

Polarity and nucleation of microtubules in polarized epithelial cells

1995 • 192 citations

Genome changes and gene expression in human solid tumors

2000 • 192 citations

Targeted inactivation of p53 in human cells does not result in aneuploidy.

2002 • 188 citations

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

2002 • 186 citations

Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis.

2002 • 182 citations

Aneuploidy, the somatic mutation that makes cancer a species of its own

2000 • 182 citations

p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.

1998 • 168 citations

The centrosome cycle

2002 • 163 citations

Mitosis in a cell with multiple centrioles.

1982 • 158 citations

Tubulin assembly sites and the organization of cytoplasmic microtubules in cultured mammalian cells.

1981 • 154 citations

Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

2001 • 145 citations

DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos

2000 • 142 citations

Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells

2002 • 135 citations

Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer.

1991 • 133 citations

How Many Mutations in a Cancer?

2002 • 129 citations

Centrosome abnormalities in pancreatic ductal carcinoma.

1999 • 129 citations

Centrosome Abnormalities and Genomic Instability by Episomal Expression of Human Papillomavirus Type 16 in Raft Cultures of Human Keratinocytes

2001 • 120 citations

p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells

1999 • 116 citations

Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability

2002 • 116 citations

Centrosome abnormalities, genomic instability and carcinogenic progression

2001 • 115 citations

The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles

2002 • 108 citations

p53-Independent Apoptosis and p53-Dependent Block of DNA Rereplication Following Mitotic Spindle Inhibition in Human Cells

1999 • 104 citations

Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells

2001 • 103 citations

Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency

1998 • 103 citations

Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation.

2002 • 103 citations

p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells

1999 • 100 citations

Integration of the centrosome in cell cycle control, stress response and signal transduction pathways

2002 • 99 citations

Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutations

1998 • 91 citations

A possible role for centrosome overduplication in radiation-induced cell death

2000 • 91 citations

The SCF ubiquitin ligase protein Slimb regulates centrosome duplication in Drosophila

2000 • 88 citations

Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest

1998 • 85 citations

The role of the centrosome in the development of malignant tumors

1999 • 84 citations

Polarities of the centriolar structure: Morphogenetic consequences

1999 • 77 citations

The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling

2002 • 77 citations

Progesterone facilitates chromosome instability (aneuploidy) in p53 null

2000 • 76 citations

Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts

2000 • 76 citations

Human Papillomavirus Infection, Centrosome Aberration, and Genetic Stability in Cervical Lesions

2001 • 65 citations

Centrosome Hyperamplification in Head and Neck Squamous Cell Carcinoma: A Potential Phenotypic Marker of Tumor Aggressiveness

2000 • 57 citations

Persistent Increase in Chromosome Instability in Lung Cancer

2001 • 52 citations

Basal cell tetrasomy in low-grade cervical squamous intraepithelial lesions infected with high-risk human papillomaviruses.

1997 • 50 citations

Centriole number and process formation in established neuroblastoma cells and primary dorsal root ganglion neurones.

1982 • 48 citations

Stepwise Progression of Centrosome Defects Associated with Local Tumor Growth and Metastatic Process of Human Pancreatic Carcinoma Cells Transplanted Orthotopically into Nude Mice

2001 • 43 citations

Overexpression of cyclin A in human HeLa cells induces detachment of kinetochores and spindle pole/centrosome overproduction

2001 • 38 citations

Centrosomes, microtubules and cell migration.

1999 • 37 citations

The coordination of centrosome reproduction with nuclear events during the cell cycle

1999 • 25 citations

Centrosome reproduction in Xenopus lysates

2001 • 7 citations

Centrosome reproduction in Vitro: Mammalian centrosomes in Xenopus lysates

2001 • 7 citations