The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial

Randomized Comparison of DAT Versus ADE as Induction Chemotherapy in Children and Younger Adults With Acute Myeloid Leukemia. Results of the Medical Research Council's 10th AML Trial (MRC AML10)

1997 • 321 citations

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

1993 • 297 citations

Prognostic significance of karyotype in de novo adult acute myeloid leukemia. The BGMT group.

1995 • 254 citations

Rearrangement of ALL1 (MLL) in acute myeloid leukemia with normal cytogenetics.

1998 • 234 citations

Cytogenetic pattern in acute myelogenous leukemia: a major reproducible determinant of outcome.

1988 • 222 citations

ALL-1 partial duplication in acute leukemia.

1994 • 219 citations

Cytogenetics and their prognostic value in de novo acute myeloid leukaemia: a report on 283 cases

1989 • 205 citations

Adult Patients With De Novo Acute Myeloid Leukemia and t(9; 11)(p22; q23) Have a Superior Outcome to Patients With Other Translocations Involving Band 11q23: A Cancer and Leukemia Group B Study

1997 • 184 citations

The clinical significance of karyotype in acute myelogenous leukemia

1989 • 174 citations

A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia

1995 • 169 citations

Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study

1995 • 168 citations

Karyotype in Acute Myeloblastic Leukemia: Prognostic Significance for Bone Marrow Transplantation in First Remission: A European Group for Blood and Marrow Transplantation Study

1997 • 165 citations

Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations

1994 • 153 citations

Long-term survival in acute myelogenous leukemia

1994 • 141 citations

Effect of aggressive daunomycin therapy on survival in acute promyelocytic leukemia

1995 • 137 citations

Molecular detection of t(8;21)/AML1‐ETO in AML M1/M2: correlation with cytogenetics, morphology and immunophenotype

1996 • 135 citations

Establishing the presence of the t( 15; 17) in suspected acute promyelocytic leukaemia: cytogenetic, molecular and PML immunofluorescence assessment of patients entered into the M.R.C. ATRA trial

1996 • 132 citations

Long-term survival of patients with acute myeloid leukemia

1997 • 131 citations

Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.

1997 • 128 citations

Secondary cytogenetic changes in acute promyelocytic leukemia--prognostic importance in patients treated with chemotherapy alone and association with the intron 3 breakpoint of the PML gene: a Cancer and Leukemia Group B study.

1997 • 126 citations

Fifty-one patients with acute myeloid leukemia and translocation t(8;21)(q22;q22): an additional deletion in 9q is an adverse prognostic factor.

1996 • 125 citations

Impact of cytogenetic abnormalities on outcome of bone marrow transplants in acute myelogenous leukemia in first remission.

1995 • 110 citations

Incidence of AML1/ETO fusion transcripts in patients entered into the MRC AML trials

1997 • 107 citations

Additional chromosome abnormalities confer worse prognosis in acute promyelocytic leukaemia

1997 • 103 citations

Prognostic significance of chromosomal abnormalities in acute nonlymphocytic leukemia: A study of 343 patients

1987 • 98 citations

Frequency of CBFβ/MYH11 fusion transcripts in patients entered into the U.K. MRC AML trials

1997 • 93 citations

Incidence and implication of additional chromosome aberrations in acute promyelocytic leukaemia with translocation t(15;17)(q22;q21): a report on 50 patients

1996 • 91 citations

Correlation between cell morphology and expression of the AML1/ETO chimeric transcript in patients with acute myeloid leukemia without the t(8;21).

1994 • 85 citations

Interstitial insertion of retinoic acid receptor-alpha gene in acute promyelocytic leukemia with normal chromosomes 15 and 17

1994 • 83 citations

Prevalence and clinical correlations of MLL gene rearrangements in AML- M4/5

1994 • 78 citations

Prognostic impact of karyotype and immunologic phenotype in 125 adult patients with de novo AML

1992 • 78 citations

Specific chromosomal abnormalities in acute nonlymphocytic leukemia correlate with drug susceptibility in vivo.

1988 • 71 citations

Acute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes

1995 • 68 citations

Abnormalities of Chromosome Band 11q23 and the MLL Gene in Pediatric Myelomonocytic and Monoblastic Leukemias

1995 • 59 citations

Disruption of a Homolog of Trithorax by 11q23 Translocations: Leukemogenic and Transcriptional Implications

1997 • 53 citations

Detection of the AML1/ETO fusion transcript in the t(8;21) masked translocation in acute myelogenous leukemia.

1993 • 43 citations

A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RARα, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia

1998 • 30 citations

5 Treatment and prognostic factors in acute myeloid leukaemia

1996 • 27 citations

Rearrangement of the AML1/CBFA2 Gene in Myeloid Leukemia with the 3;21 Translocation:Expression of Co-Existing Multiple Chimeric Genes with Similar Functions as Transcriptional Repressors, but with Opposite Tumorigenic Properties

1996 • 26 citations

Karyotype in acute myeloblastic leukemia: prognostic significance in a prospective study assessing bone marrow transplantation in first remission.

1995 • 25 citations

Molecular Analysis of Evi1, a Zinc Finger Oncogene Involved in Myeloid Leukemia

1996 • 25 citations

Deleted Work

1955 • 0 citations

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