Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

1985 • 2,840 citations

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

1981 • 2,281 citations

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982 • 2,170 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 2,119 citations

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

1983 • 1,555 citations

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells

1981 • 1,429 citations

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

1984 • 886 citations

RNA tumor viruses

1982 • 833 citations

Trans -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells

1984 • 781 citations

A Retrospective Study on Transmission of Adult T Cell Leukemia Virus by Blood Transfusion: Seroconversion in Recipients

1984 • 641 citations

Antibodies to adult t‐cell leukemia‐virus‐associated antigen (atla) in sera from patients with atl and controls in japan: A nation‐wide sero‐epidemiologic study

1982 • 607 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

1990 • 439 citations

HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene

1990 • 329 citations

The 4th nation‐wide study of adult T‐cell leukemia/lymphoma (ATL) in Japan: Estimates of risk of ATL and its geographical and clinical features

1990 • 304 citations

Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells

1984 • 293 citations

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

1989 • 289 citations

Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor.

1985 • 283 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins.

1988 • 273 citations

Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells.

1985 • 237 citations

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells.

1990 • 222 citations

Expression of the pX Gene of HTLV-I: General Splicing Mechanism in the HTLV Family

1985 • 201 citations

Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I.

1992 • 192 citations

Human adult T-cell leukemia virus: molecular cloning of the provirus DNA and the unique terminal structure.

1982 • 188 citations

p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I.

1985 • 166 citations

HTLV type I (U. S. isolate) and ATLV (Japanese isolate) are the same species of human retrovirus

1984 • 165 citations

Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type I.

1988 • 150 citations

Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappa B and induces nuclear translocation of transcription factor NF-kappa B proteins for transcriptional activation.

1994 • 142 citations

Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control

1999 • 122 citations

Inhibition of Apoptosis in T Cells Expressing Human T Cell Leukemia Virus Type I Tax

1994 • 112 citations

Significance of Postnatal Mother-to-Child Transmission of Human T-lymphotropic Virus Type-I on the Development of Adult T-cell Leukemia/Lymphoma

1986 • 110 citations

Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration

2003 • 103 citations

Trans-activator Tax of Human T-Cell Leukemia Virus Type 1 Enhances Mutation Frequency of the Cellular Genome

1999 • 78 citations

A Retrospective Study on Transmission of Adult T Cell Leukemia Virus by Blood Transfusion: Seroconversion in Recipients

1984 • 77 citations

Adult T-cell leukemia/lymphoma not associated with human T-cell leukemia virus type I.

1986 • 71 citations

The Human T-Lymphotropic Virus Type I tax Gene Can Cooperate with the ras Oncogene To Induce Neoplastic Transformation of Cells

1990 • 33 citations

HTLV-1 Tax Oncoprotein Binds to DNA Topoisomerase I and Inhibits Its Catalytic Activity

2000 • 28 citations

Malignant lymphomas in Japan: Epidemiological analysis on adult t‐cell leukemia/lymphoma

1986 • 21 citations