Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

1981 • 2,281 citations

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982 • 2,170 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Centrosome aberrations: cause or consequence of cancer progression?

2002 • 725 citations

Aneuploidy and cancer

2004 • 710 citations

Centrosome defects and genetic instability in malignant tumors.

1998 • 583 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression.

2001 • 330 citations

Centrosome amplification and the development of cancer

2002 • 277 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

1996 • 266 citations

Discovery of adult T-cell leukemia

2005 • 223 citations

The Ran GTPase: Theme and Variations

2002 • 210 citations

pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation

1999 • 199 citations

The discovery of the first human retrovirus: HTLV-1 and HTLV-2

2005 • 186 citations

Loss of p53 and centrosome hyperamplification

2002 • 184 citations

HTLV-1 Tax induces expression of various immediate early serum responsive genes.

1991 • 177 citations

Life, Death, and Tax: Role of HTLV-I Oncoprotein in Genetic Instability and Cellular Transformation

2004 • 169 citations

The centrosome cycle

2002 • 163 citations

The Ran decathlon: multiple roles of Ran

2000 • 162 citations

Centrosome replication, genomic instability and cancer

2002 • 160 citations

Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)

2005 • 157 citations

Physical Interaction of Human T-Cell Leukemia Virus Type 1 Tax with Cyclin-Dependent Kinase 4 Stimulates the Phosphorylation of Retinoblastoma Protein

2002 • 140 citations

Stimulation of Cyclin-Dependent Kinase Activity and G₁- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein

1998 • 133 citations

Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-κB

2001 • 126 citations

Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability

2002 • 116 citations

Prevalent Loss of Mitotic Spindle Checkpoint in Adult T-cell Leukemia Confers Resistance to Microtubule Inhibitors

2002 • 110 citations

Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-κB activation

2001 • 101 citations

Human T-cell Leukemia Virus-I Tax Oncoprotein Functionally Targets a Subnuclear Complex Involved in Cellular DNA Damage-Response

2003 • 93 citations

Beyond Nuclear Transport

1999 • 91 citations

Protein Profile of Tax-associated Complexes

2003 • 88 citations

Mammalian RanBP1 regulates centrosome cohesion during mitosis

2003 • 85 citations

Centrosome Amplification and the Origin of Chromosomal Instability in Breast Cancer

2004 • 83 citations

Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes S-Phase Entry but Blocks Mitosis

2002 • 80 citations

Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo.

2000 • 79 citations

Regulation of human T cell leukemia virus expression ¹

1990 • 78 citations

Human T-Cell Leukemia Virus Type 1 Tax Shuttles between Functionally Discrete Subcellular Targets

2000 • 73 citations

Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes Unscheduled Degradation of Pds1p/Securin and Clb2p/Cyclin B1 and Causes Chromosomal Instability

2003 • 72 citations

CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein

2001 • 63 citations

Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression

2003 • 61 citations

Interaction of Retroviral Tax Oncoproteins With Tristetraprolin and Regulation of Tumor Necrosis Factor- Expression

2003 • 57 citations

Human T-Cell Leukemia Virus Type 2 Tax Mutants That Selectively Abrogate NFκB or CREB/ATF Activation Fail To Transform Primary Human T Cells

2000 • 56 citations

The Centrosome in Normal and Transformed Cells

2004 • 56 citations

Damaged DNA and miscounted chromosomes: Human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells

2002 • 54 citations

The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells.

2004 • 51 citations

The HTLV-1 Tax Oncoprotein Attenuates DNA Damage Induced G1 Arrest and Enhances Apoptosis in p53 Null Cells

2003 • 49 citations

A New Role of Ran GTPase

1999 • 41 citations

Cell cycle: Driving the centrosome cycle

1999 • 36 citations

Transcriptional control of the Htf9-A/RanBP-1 gene during the cell cycle.

1995 • 34 citations

Targeting of Ran: variation on a common theme?

2001 • 33 citations

HTLV-I Tax and cell cycle progression

2000 • 33 citations

The Centrosome

1993 • 31 citations

Emerging roles of centrosomal amplification and genomic instability in cancer

2005 • 24 citations

Centrosome Aberrations and Cancer

2001 • 19 citations

Transcriptional Activity of HTLV‐I Tax Influences the Expression of Marker Genes Associated with Cellular Transformation

2001 • 11 citations

Chapter 14: Centrosome Dynamics in Living Cells

1998 • 9 citations

The centrosome and parthenogenesis

1999 • 6 citations

Genetic immune modulation of Ran GTPase against different microbial pathogens

2004 • 5 citations