Evidence for NF-κB- and CBP-Independent Repression of p53's Transcriptional Activity by Human T-Cell Leukemia Virus Type 1 Tax in Mouse Embryo and Primary Human Fibroblasts

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982 • 2,170 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

1990 • 439 citations

Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

1995 • 364 citations

Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.

1989 • 359 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

IKKγ Serves as a Docking Subunit of the IκB Kinase (IKK) and Mediates Interaction of IKK with the Human T-cell Leukemia Virus Tax Protein

1999 • 227 citations

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells.

1990 • 222 citations

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

1999 • 216 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

1990 • 181 citations

IKKγ Mediates the Interaction of Cellular IκB Kinases with the Tax Transforming Protein of Human T Cell Leukemia Virus Type 1

1999 • 181 citations

Persistent activation of NF-κB by the Tax transforming protein of HTLV-1: hijacking cellular IκB kinases

1999 • 181 citations

Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein

1998 • 174 citations

Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain

1998 • 174 citations

Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.

2004 • 147 citations

Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-κB Pathway and Is Dependent on p53 Phosphorylation

2000 • 136 citations

Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins

1992 • 135 citations

Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells

1998 • 134 citations

HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

2000 • 118 citations

p300 and p300/cAMP-responsive Element-binding Protein Associated Factor Interact with Human T-cell Lymphotropic Virus Type-1 Tax in a Multi-histone Acetyltransferase/Activator-Enhancer Complex

2000 • 109 citations

Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I.

1993 • 107 citations

Human T-lymphotropic Virus Type I Tax Activates I-κB Kinase by Inhibiting I-κB Kinase-associated Serine/Threonine Protein Phosphatase 2A

2003 • 93 citations

Aberrant expression and function of p53 in T‐cells immortalized by HTLV‐I Tax1

1997 • 81 citations

A Novel NF-κB Pathway Involving IKKβ and p65/RelA Ser-536 Phosphorylation Results in p53 Inhibition in the Absence of NF-κB Transcriptional Activity

2004 • 78 citations

The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein

1995 • 74 citations

Segregation of NF-κB activation through NEMO/IKKγ by Tax and TNFα: implications for stimulus-specific interruption of oncogenic signaling

2003 • 66 citations

p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14ARF–MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells

2000 • 65 citations

Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control

1999 • 49 citations

Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53

2001 • 48 citations

Insights into the Molecular Mechanism of p53 Inhibition by HTLV Type 1 Tax

2000 • 46 citations

Differential Requirements for Activation of Integrated and Transiently Transfected Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

2002 • 45 citations

p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14ARF–MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells

2000 • 34 citations

The Human T-Lymphotropic Virus Type I tax Gene Can Cooperate with the ras Oncogene To Induce Neoplastic Transformation of Cells

1990 • 33 citations