The HTLV-1 Tax Oncoprotein Attenuates DNA Damage Induced G1 Arrest and Enhances Apoptosis in p53 Null Cells

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

1985 • 2,840 citations

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982 • 2,170 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control

2001 • 457 citations

The tumore suppressor p53

1993 • 336 citations

HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene

1990 • 329 citations

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.

1986 • 229 citations

Mutations of the p53 gene in adult T-cell leukemia

1992 • 223 citations

Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb

1998 • 188 citations

Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia

1995 • 175 citations

Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain

1998 • 174 citations

The x Gene Is Essential for HTLV Replication

1985 • 161 citations

Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-κB Pathway and Is Dependent on p53 Phosphorylation

2000 • 136 citations

Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins

1992 • 135 citations

Stimulation of Cyclin-Dependent Kinase Activity and G₁- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein

1998 • 133 citations

Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I

2001 • 131 citations

Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein

1999 • 120 citations

Down-regulation of the INK4 Family of Cyclin-Dependent Kinase Inhibitors by Tax Protein of HTLV-1 through Two Distinct Mechanisms

1999 • 119 citations

Binding of p53 to the KIX Domain of CREB Binding Protein

1999 • 108 citations

p53 expression overcomes p21WAF1/CIP1-mediated G1 arrest and induces apoptosis in human cancer cells

1997 • 97 citations

Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site

1999 • 94 citations

Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells

1999 • 92 citations

HTLV-I and HTLV-II Tax: Differences in Induction of Micronuclei in Cells and Transcriptional Activation of Viral LTRs

1996 • 90 citations

Induction of Micronuclei by HTLV-I Tax: A Cellular Assay for Function

1993 • 89 citations

Trans-activator Tax of Human T-Cell Leukemia Virus Type 1 Enhances Mutation Frequency of the Cellular Genome

1999 • 78 citations

Absence of p53 permits propagation of mutant cells following genotoxic damage

1997 • 77 citations

Clastogenic Effect of the Human T-cell Leukemia Virus Type I Tax Oncoprotein Correlates with Unstabilized DNA Breaks

2000 • 73 citations

Mechanisms of tax regulation of human T cell leukemia virus type I gene expression

1995 • 70 citations

Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter

1997 • 68 citations

p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14ARF–MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells

2000 • 65 citations

Accelerated G1 Phase Progression Induced by the Human T Cell Leukemia Virus Type I (HTLV-I) Tax Oncoprotein

2001 • 61 citations

p53 gene mutation and loss of heterozygosity are associated with increased risk of disease progression in adult T cell leukemia.

1995 • 56 citations

HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents

2000 • 53 citations

Endogenous p53 gene status predicts the response of human squamous cell carcinomas to wild-type p53

2000 • 45 citations

Analysis of p53 Inactivation in a Human T-Cell Leukemia Virus Type 1 Tax Transgenic Mouse Model

2001 • 34 citations

HTLV-I Tax and cell cycle progression

2000 • 33 citations

Effects of p53 mutation on tumor progression: recent insights from mouse tumor models

1996 • 33 citations

Effects of Exogenous p53 Transduction in Thyroid Tumor Cells with Different p53 Status¹

2000 • 30 citations

Human T-cell Leukemia Virus Type I Tax Masks c-Myc Function through a cAMP-dependent Pathway

1996 • 30 citations

HTLV-1 Tax Oncoprotein Binds to DNA Topoisomerase I and Inhibits Its Catalytic Activity

2000 • 28 citations

Genetic background determines the response to adenovirus-mediated wild-type p53 expression in pancreatic tumor cells

1999 • 27 citations

p53-Independent Induction of Apoptosis by the HTLV-I Tax Protein Following UV Irradiation

2001 • 25 citations

Analysis of p18^INK4C in adult T‐cell leukaemia and non‐Hodgkin's lymphoma

1997 • 21 citations

Effects of Exogenous p53 Transduction in Thyroid Tumor Cells with Different p53 Status

2000 • 18 citations